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Polydisperse polystyrene microplastics exacerbate colitis through gut microbiota-butyrate-PPARγ axis disruption in mice
npj Emerging Contaminants
2026
Zhian Zhai,
Yi Yang,
Yifei Xu,
Qingyao Fu,
Sheng Chen,
Zhenlong Wu
Summary
This study demonstrates that exposure to polydisperse polystyrene microplastics worsens colitis symptoms in experimental animal models. The microplastics appear to aggravate intestinal inflammation by disrupting gut barrier function and amplifying immune responses. These results raise concern about microplastic exposure as a potential risk factor for inflammatory bowel conditions.