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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Gut & Microbiome Human Health Effects Policy & Risk Reproductive & Development Sign in to save

Impact of Microplastics on Human Health: Risks, Diseases, and Affected Body Systems

Microplastics 2025 31 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 73 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Ghulam Abbas, Usama Ahmed, Muhammad Arslan Ahmad

Summary

This review summarizes how microplastics made of polystyrene, polypropylene, and polyethylene affect multiple body systems, causing inflammation in the lungs and gut, weakening immune function, and increasing risks of cardiovascular disease and brain toxicity. These particles also disrupt hormones, which may lead to reproductive problems and elevated cancer risk, underscoring the need for stronger regulations on plastic materials.

This review article aims to highlight the potential harm caused by microplastics (MPs) in different organs and systems and underscore the need for further investigation into their action mechanisms. MPs, such as polystyrene, polypropylene, and polyethylene, significantly impact human health, causing inflammation in the respiratory and gastrointestinal systems, compromising immune function, and increasing the risk of cardiovascular diseases and neurotoxicity. These effects are largely attributed to the role of MPs in disrupting hormonal regulation, which can lead to reproductive disorders and an elevated risk of cancer. These microscopic particles (less than 5 mm in size) are now ubiquitous in air, water, and food. However, much of the existing research on MPs focuses on their mechanisms of action and their association with health and disease, with limited emphasis on their direct impact on humans or long-term consequences. To effectively address plastic toxicity, it is crucial to understand the policy implications of MPs and their relevance to disease development. Recent research has highlighted the need for more stringent regulatory oversight of these materials to better understand and mitigate their impact on human health.

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