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Bio-Based Degradation of Plastics and Microplastic for Sustainable Environment

2026

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This review summarizes research on special bacteria, enzymes, and plant-based plastics that can break down plastic waste into harmless substances like water and CO2. Since plastic and microplastic pollution can enter our food, water, and bodies, these biological cleanup tools could help reduce our long-term exposure while also easing environmental damage.

Polymers

Abstract The escalating proliferation of plastic and microplastic pollutants in the environment has emerged as major ecological and toxicological challenge due to the intrinsic recalcitrance of synthetic polymers. Bio-based degradation emerges as a sustainable paradigm, employing metabolically versatile microorganisms, catalytic enzymes, and renewable biopolymers to facilitate the depolymerization and mineralization of plastics into benign metabolites such as CO2, H2O, and microbial biomass. Enzymatic systems particularly PETase, MHETase, and lipases derived from Ideonella sakaiensis, Pseudomonas putida, and Aspergillus niger exemplify the biochemical precision required for polymer disintegration. At the same time, bioengineered polymers including polylactic acid (PLA), polyhydroxybutyrate (PHB), and polyhydroxyalkanoates (PHA) signify an evolution toward inherently degradable materials. Despite challenges associated with slow degradation rates, polymer crystallinity, and process scalability, advancements in synthetic biology, enzyme engineering, and nano-biocatalyst integration demonstrate significant potential for enhancing plastic biodegradation efficiency. Therefore, bio-based plastic degradation offers a promising biotechnological strategy for achieving a circular, carbon-neutral, and environmentally resilient future.

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