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Microplastic biodegradation and environmental safety: From microbial mechanisms to engineered systems and circular bio-based implementation.

Ecotoxicology and environmental safety 2026 Score: 40 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Haixin Jiao, Rania Al-Tohamy, Min Xiong, Michael Schagerl, Thomas Reinthaler, Majid Al-Zahrani, Jianzhong Sun, Sameh S Ali

Summary

This research review summarizes what scientists know about using bacteria and enzymes to break down microplastics—tiny plastic particles smaller than 5mm that contaminate our water, soil, and air. While these biological approaches show promise for removing dangerous plastic pollution from the environment, the methods don't always work completely and may create new harmful byproducts. The findings matter because microplastics can enter our food chain and bodies, so we need safe and effective ways to remove them without creating new health risks.

Microplastics, defined as synthetic polymer particles smaller than 5 mm, have become pervasive environmental contaminants across aquatic, terrestrial, and atmospheric systems. Their chemical stability, hydrophobicity, and resistance to natural attenuation limit the effectiveness of conventional physical and chemical removal technologies. Microbial and enzymatic approaches have therefore emerged as promising strategies for microplastic transformation and controlled degradation, although complete mineralization is not consistently achieved. Degradation outcomes vary widely depending on polymer structure, environmental conditions, and microbial community dynamics, and incomplete depolymerization may generate intermediate products with distinct ecological implications. This review provides a mechanistically integrated analysis of microplastic biodegradation, explicitly distinguishing surface modification, depolymerization, biotransformation, and complete mineralization. Abiotic preconditioning processes, enzyme-polymer interactions, kinetic constraints in real environmental matrices, and the functional roles of single strains, microbial consortia, and genetically engineered systems are examined. Particular attention is given to environmental safety considerations, including degradation byproducts, additive release, horizontal gene transfer risks, and biosafety containment strategies. The feasibility of integrating microbial degradation into circular bio-based recycling frameworks is critically assessed through translational strategies, pilot-scale considerations, and life cycle perspectives. Although advances in enzyme engineering and synthetic biology have significantly improved depolymerization efficiency under controlled conditions, scalability, regulatory compliance, and ecosystem-level risk assessment remain central challenges. Bridging mechanistic insight with environmental realism and regulatory preparedness is essential to ensure that biodegradation strategies reduce environmental burden without redistributing ecological risk.

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