OS01-09 Assessing the toxicity of fragmented virgin and aged polyamide microplastics on human tissue-derived intestinal organoids

Evaluation of intestinal toxicity of polystyrene micro/nanoplastics using intestinal organoids

Microplastics: fate in the human digestive environment in vitro and study of the epithelium / microbiota / mucus dialogue

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Using lab-grown models of the human gut, scientists found that everyday microplastics from food and water can shift gut bacteria toward more harmful types in both adults and toddlers, and specifically reduce production of butyrate, a beneficial compound that keeps the gut lining healthy, in infants. While the microplastics didn't directly damage the intestinal barrier in this study, the disruption to beneficial gut bacteria matters because a healthy microbiome is crucial for digestion, immunity, and overall health, especially in young children whose gut systems are still developing.

Impact of Microplastics on the Severity of Intestinal Inflammation in Mice

Impact of Micro-nanoplastics on Gut and Immune Function

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This review examined how micro- and nanoplastics disrupt gut microbiota and immune function across aquatic and terrestrial vertebrates, with implications for human health. Because the gut microbiome governs immune regulation and metabolic health, microplastic-induced dysbiosis represents a plausible mechanism by which plastic ingestion could drive systemic inflammation and disease beyond the GI tract.

Cellular and Animal Toxicities of Micro- and Nanoplastics

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Researchers reviewed evidence from cell and animal studies on the toxic effects of micro- and nanoplastics, finding that these particles can cause inflammation, oxidative stress, and organ damage in laboratory models, raising concern about what chronic low-level human exposure might mean for long-term health.