Additional file 2 of Butyrate-producing gut bacteria restrain PBAT microplastic-triggered brain microglial lipotoxicity via a microbiota–butyrate–mTORC1–ISR relay along the gut–brain axis

Ming-Zhu Wang; Ze‐Bang Du; Wen-Qi Xu; Yu-Han Xie; L S Wang; Xin-Xin He; Yuxing Wang; Han-Ying Zheng; You-Liang Yao; Song Ya-bin; Zhong‐Ning Lin; Yuxin Lin

doi:10.6084/m9.figshare.32930889.v1

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Additional file 2 of Butyrate-producing gut bacteria restrain PBAT microplastic-triggered brain microglial lipotoxicity via a microbiota–butyrate–mTORC1–ISR relay along the gut–brain axis

Original title: Additional file 2 of Butyrate-producing gut bacteria restrain PBAT microplastic-triggered brain microglial lipotoxicity via a microbiota–butyrate–mTORC1–ISR relay along the gut–brain axis

Figshare 2026

Ming-Zhu Wang, Ze‐Bang Du, Wen-Qi Xu, Yu-Han Xie, L S Wang, Xin-Xin He, Yuxing Wang, Han-Ying Zheng, You-Liang Yao, Song Ya-bin, Zhong‐Ning Lin, Yuxin Lin

Summary

This study found that microplastics (from a biodegradable plastic called PBAT) can harm brain cells by triggering harmful fat buildup, but healthy gut bacteria that produce a substance called butyrate can help protect against this damage. This matters because it suggests the health of your gut microbiome—shaped by diet and lifestyle—may influence how vulnerable your brain is to microplastic exposure, which is increasingly common in our food and environment. The research points to gut bacteria as a possible future target for protecting brain health from plastic pollution, though more studies are needed to confirm this works in humans.