Additional file 2 of Butyrate-producing gut bacteria restrain PBAT microplastic-triggered brain microglial lipotoxicity via a microbiota–butyrate–mTORC1–ISR relay along the gut–brain axis

Ming-Zhu Wang; Ze‐Bang Du; Wen-Qi Xu; Yu-Han Xie; L S Wang; Xin-Xin He; Yuxing Wang; Han-Ying Zheng; You-Liang Yao; Song Ya-bin; Zhong‐Ning Lin; Yuxin Lin

doi:10.6084/m9.figshare.32930889

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Additional file 2 of Butyrate-producing gut bacteria restrain PBAT microplastic-triggered brain microglial lipotoxicity via a microbiota–butyrate–mTORC1–ISR relay along the gut–brain axis

Original title: Additional file 2 of Butyrate-producing gut bacteria restrain PBAT microplastic-triggered brain microglial lipotoxicity via a microbiota–butyrate–mTORC1–ISR relay along the gut–brain axis

Figshare 2026

Ming-Zhu Wang, Ze‐Bang Du, Wen-Qi Xu, Yu-Han Xie, L S Wang, Xin-Xin He, Yuxing Wang, Han-Ying Zheng, You-Liang Yao, Song Ya-bin, Zhong‐Ning Lin, Yuxin Lin

Summary

This study found that microplastics from biodegradable plastics (called PBAT) can harm brain cells by triggering harmful fat buildup, but certain "good" gut bacteria may help protect against this damage by producing a beneficial compound called butyrate. This matters because it suggests the health of your gut microbiome could influence how vulnerable your brain is to everyday plastic exposure, and points to gut bacteria as a possible way to guard against microplastic-related brain harm. Since this research was done in animal models, more studies are needed to confirm these effects apply to humans.