Additional file 1 of Butyrate-producing gut bacteria restrain PBAT microplastic-triggered brain microglial lipotoxicity via a microbiota–butyrate–mTORC1–ISR relay along the gut–brain axis

Ming-Zhu Wang; Ze‐Bang Du; Wen-Qi Xu; Yu-Han Xie; L S Wang; Xin-Xin He; Yuxing Wang; Han-Ying Zheng; You-Liang Yao; Song Ya-bin; Zhong‐Ning Lin; Yuxin Lin

doi:10.6084/m9.figshare.32930886

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Additional file 1 of Butyrate-producing gut bacteria restrain PBAT microplastic-triggered brain microglial lipotoxicity via a microbiota–butyrate–mTORC1–ISR relay along the gut–brain axis

Original title: Additional file 1 of Butyrate-producing gut bacteria restrain PBAT microplastic-triggered brain microglial lipotoxicity via a microbiota–butyrate–mTORC1–ISR relay along the gut–brain axis

Figshare 2026

Ming-Zhu Wang, Ze‐Bang Du, Wen-Qi Xu, Yu-Han Xie, L S Wang, Xin-Xin He, Yuxing Wang, Han-Ying Zheng, You-Liang Yao, Song Ya-bin, Zhong‐Ning Lin, Yuxin Lin

Summary

This study finds that tiny plastic particles from biodegradable plastics (PBAT, used in things like compostable bags) can harm brain cells by triggering harmful fat buildup, but healthy gut bacteria that produce a compound called butyrate can help protect the brain from this damage. This matters because it suggests that even "eco-friendly" plastics may pose hidden risks to brain health, and that maintaining a healthy gut microbiome—through diet or other means—could be a key defense against microplastic exposure. Note: this research was conducted in animal models, so more studies are needed to confirm these effects in humans.