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Silver and Polystyrene Nanoparticles Act as Endocrine Disruptors via Copper-Dependent CK2/AKT Signaling in Breast Cancer
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Scientists found that tiny particles of silver (used in some antibacterial products) and polystyrene (a common type of microplastic) can interfere with hormone-related signaling in breast cancer cells, and that copper plays a key role in triggering this effect. This matters because it suggests these widespread materials may act as "endocrine disruptors" — substances that can throw off the body's natural hormone balance — raising questions about their long-term safety, especially for hormone-sensitive tissues.
Dataset from grant OPUS 20 “Nanoplastic and silver nanoparticles as a factor modulating the activity of estrogen-dependent intracellular signaling pathways in in vitro and in vivo systems”, no. 2020/39/B/NZ7/03197.
More Papers Like This
Silver and Polystyrene Nanoparticles Act as Endocrine Disruptors via Copper-Dependent CK2/AKT Signaling in Breast Cancer
AI summary Read the abstract
Scientists found that tiny particles of silver (used in some consumer products) and polystyrene (a common type of microplastic) can interfere with hormone-related signals in breast cancer cells, acting a bit like fake estrogen and disrupting normal cell communication. This matters because it suggests everyday exposure to these tiny particles might have effects on hormone-sensitive tissues, though more research is needed to know what this means for real-world human health risk.
Silver and polystyrene nanoparticles activate oestrogen signalling via cytoplasmic oestrogen receptor
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This study found that both nanoplastic polystyrene particles and silver nanoparticles (AgNPs) activate estrogen signaling in breast cancer cells by binding to cytoplasmic estrogen receptors. The results suggest these two common nanomaterials are endocrine disruptors capable of mimicking estrogenic activity, with potential implications for hormone-driven diseases.
Citrate silver nanoparticles modulate estrogen signaling in estradiol-supplemented ER-positive breast cancer cells
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Researchers found that the surface chemistry of citrate-coated silver nanoparticles can modulate estrogen signaling and interact with estrogen receptors in breast cancer cells. The study suggests that nanoplastics pollution in the environment may influence the toxicity of silver nanoparticles, highlighting the need for more endocrine research at the intersection of nanoplastics contamination and nanotechnology.
Polystyrene Nanoplastics as Carriers of Metals. Interactions of Polystyrene Nanoparticles with Silver Nanoparticles and Silver Nitrate, and Their Effects on Human Intestinal Caco-2 Cells
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Researchers investigated whether polystyrene nanoplastics can act as carriers of silver contaminants, testing their interactions with silver nanoparticles and silver nitrate and their combined effects on human intestinal Caco-2 cells. The study found that nanoplastics can adsorb silver compounds and that the combined exposure increased toxicity compared to either contaminant alone, suggesting nanoplastics may enhance metal uptake in the human gut.
The Impact of Endocrine Disruptions on Animal and Human Organism
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This review examines how endocrine-disrupting chemicals, including bisphenol A, phthalates, and micro- and nanoplastics, interfere with hormonal balance in animals and humans. Researchers describe how these substances interact with hormone receptors, induce epigenetic changes, and disrupt cell signaling pathways affecting reproduction, metabolism, and neurological function. The study highlights that nanoparticles, including microplastics, may amplify endocrine disruption and calls for more research into the molecular pathways involved.
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