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Silver and Polystyrene Nanoparticles Act as Endocrine Disruptors via Copper-Dependent CK2/AKT Signaling in Breast Cancer

Zenodo (CERN European Organization for Nuclear Research) 2026
Michał Rakowski, Agnieszka Grzelak, Szymon Adam Lekki-Porębski

Summary

Scientists found that tiny particles of silver (used in some antibacterial products) and polystyrene (a common type of microplastic) can interfere with hormone-related signaling in breast cancer cells, and that copper plays a key role in triggering this effect. This matters because it suggests these widespread materials may act as "endocrine disruptors" — substances that can throw off the body's natural hormone balance — raising questions about their long-term safety, especially for hormone-sensitive tissues.

Polymers
Body Systems
Study Type In vivo

Dataset from grant OPUS 20 “Nanoplastic and silver nanoparticles as a factor modulating the activity of estrogen-dependent intracellular signaling pathways in in vitro and in vivo systems”, no. 2020/39/B/NZ7/03197.

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