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Citrate silver nanoparticles modulate estrogen signaling in estradiol-supplemented ER-positive breast cancer cells

Molecular and Cellular Endocrinology 2026
Michał Rakowski, Szymon Adam Lekki-Porębski, Katarzyna Sikorska, Marcin Kruszewski, Agnieszka Grzelak, Agnieszka Grzelak

Summary

Researchers found that the surface chemistry of citrate-coated silver nanoparticles can modulate estrogen signaling and interact with estrogen receptors in breast cancer cells. The study suggests that nanoplastics pollution in the environment may influence the toxicity of silver nanoparticles, highlighting the need for more endocrine research at the intersection of nanoplastics contamination and nanotechnology.

Body Systems

Our results suggest that the surface chemistry of silver nanoparticles may facilitate their ability to modulate estrogen signaling and interact with the estrogen receptor. Furthermore, the nanoplastics pollution may influence the cytotoxicity of silver nanoparticles. This paper highlights the importance of endocrine research in breast cancer, particularly within the context of nanoplastics pollution and the use of nanotechnology in breast cancer treatment.

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