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Citrate silver nanoparticles modulate estrogen signaling in estradiol-supplemented ER-positive breast cancer cells
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Researchers found that the surface chemistry of citrate-coated silver nanoparticles can modulate estrogen signaling and interact with estrogen receptors in breast cancer cells. The study suggests that nanoplastics pollution in the environment may influence the toxicity of silver nanoparticles, highlighting the need for more endocrine research at the intersection of nanoplastics contamination and nanotechnology.
Our results suggest that the surface chemistry of silver nanoparticles may facilitate their ability to modulate estrogen signaling and interact with the estrogen receptor. Furthermore, the nanoplastics pollution may influence the cytotoxicity of silver nanoparticles. This paper highlights the importance of endocrine research in breast cancer, particularly within the context of nanoplastics pollution and the use of nanotechnology in breast cancer treatment.
More Papers Like This
Silver and polystyrene nanoparticles activate oestrogen signalling via cytoplasmic oestrogen receptor
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This study found that both nanoplastic polystyrene particles and silver nanoparticles (AgNPs) activate estrogen signaling in breast cancer cells by binding to cytoplasmic estrogen receptors. The results suggest these two common nanomaterials are endocrine disruptors capable of mimicking estrogenic activity, with potential implications for hormone-driven diseases.
Silver and Polystyrene Nanoparticles Act as Endocrine Disruptors via Copper-Dependent CK2/AKT Signaling in Breast Cancer
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Scientists found that tiny particles of silver (used in some consumer products) and polystyrene (a common type of microplastic) can interfere with hormone-related signals in breast cancer cells, acting a bit like fake estrogen and disrupting normal cell communication. This matters because it suggests everyday exposure to these tiny particles might have effects on hormone-sensitive tissues, though more research is needed to know what this means for real-world human health risk.
Silver and Polystyrene Nanoparticles Act as Endocrine Disruptors via Copper-Dependent CK2/AKT Signaling in Breast Cancer
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Scientists found that tiny particles of silver (used in some antibacterial products) and polystyrene (a common type of microplastic) can interfere with hormone-related signaling in breast cancer cells, and that copper plays a key role in triggering this effect. This matters because it suggests these widespread materials may act as "endocrine disruptors" — substances that can throw off the body's natural hormone balance — raising questions about their long-term safety, especially for hormone-sensitive tissues.
Nanoplastics increase in vitro oestrogenic activity of neurotherapeutic drugs
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Researchers found that polystyrene nanoplastics significantly enhance the estrogenic activity of neurotherapeutic drugs in vitro, suggesting that nanoplastic contamination of drinking water and food could increase hormonal exposures from pharmaceutical residues.
Surface-driven endocrine activity of nanoplastics: polymer- and size-dependent estrogen and androgen receptors modulation without steroidogenesis perturbation
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Scientists tested tiny plastic particles from common plastics (like polyethylene and polypropylene, found in packaging and cosmetics) to see if they mess with hormone signals in human cells. They found that certain plastic types and sizes could mimic estrogen or block testosterone activity on their own—and surprisingly, mixtures of plastics sometimes caused hormone disruption even when the individual plastics alone didn't. This suggests that not all plastics affect our hormones the same way, and real-world exposure to plastic mixtures (as we'd actually encounter them) may pose risks that testing single plastics alone would miss
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.