O-192 The presence of microplastics in testicular tissue: implications for male infertility

Abstract Study question This study investigates the presence of microplastics in testicular tissue and explores their potential connection to male infertility. Summary answer This study demonstrates microplastic infiltration in testicular tissue, suggesting a link to male infertility, and calls for further research and health measures to reduce exposure. What is known already Microplastics (MPs), ubiquitous environmental pollutants, have recently been identified in various human tissues, raising concerns about their potential effects on health. In the context of male reproductive health, the infiltration of MPs into testicular tissue may disrupt spermatogenesis, hormone production, and overall fertility Study design, size, duration This meta-analysis systematically reviewed studies investigating the presence of microplastics in testicular tissue and their impact on male infertility. A total of 15 studies, published between 2010 and 2024, were included in the analysis. The studies varied in sample sizes, with a combined total of 1,200 male patients. The analysis assessed the relationship between microplastic exposure and male fertility outcomes, including sperm count, semen quality, and histopathological findings, over durations from 1 to 5 years. Participants/materials, setting, methods Testicular tissue samples were collected from male patients undergoing infertility diagnostics. Microplastics were identified and quantified using spectroscopy and electron microscopy. Patient histories, including environmental exposure and lifestyle factors, were analyzed for correlations. Histopathological examination assessed tissue damage, such as inflammation, disrupted seminiferous tubules, and oxidative stress. Environmental exposure to microplastics was evaluated based on sources like contaminated water and food. Statistical analysis determined significance of findings related to sperm count and tissue damage. Main results and the role of chance Microplastics were detected in 68% of the testicular tissue samples analyzed. The majority of the identified particles were polyethylene and polystyrene, with sizes ranging from 1 to 20 μm. Patients with detectable MPs in their testicular tissue exhibited significantly lower sperm counts (mean: 12 million/mL) compared to those without (mean: 26 million/mL, p < 0.01). Histological findings revealed inflammation, disrupted seminiferous tubules, and evidence of oxidative stress in tissues containing MPs. Environmental exposure to MPs, such as through contaminated water and food, was significantly higher in affected patients. Limitations, reasons for caution Limitations include variability in study methodologies, sample sizes, and diagnostic techniques, leading to potential heterogeneity. Microplastic detection methods remain evolving, and the long-term effects on male fertility are unclear. Confounding factors, such as genetic predispositions and lifestyle, were not always controlled. Further prospective studies are necessary to establish causality. Wider implications of the findings The findings suggest microplastic exposure may impact male fertility, emphasizing the need for public health efforts to reduce environmental pollutants. We call for further research into the long-term effects of microplastics on reproductive health and the development of strategies to mitigate exposure through policy and sustainable practices. Trial registration number No