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Polystyrene nanobeads exacerbate chronic colitis in mice involving in oxidative stress and hepatic lipid metabolism
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Researchers found that polystyrene nanoparticles worsen chronic colitis in mice by inducing oxidative stress and disrupting hepatic lipid metabolism, suggesting that populations with existing inflammatory bowel conditions face heightened vulnerability to microplastic exposure.
PS-NPs exacerbate intestinal inflammation and injury in mice with chronic colitis. This finding highlights chronically ill populations' susceptibility to environmental hazards, which urgent more research and risk assessment studies.
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Polystyrene micro- and nanoplastics in a colitis mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
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Researchers exposed colitis mouse models to polystyrene micro- and nanoplastics to test whether MNP exposure worsens inflammatory bowel disease, finding that MNPs altered biodistribution and exacerbated inflammatory responses in animals with pre-existing gut inflammation.
Polystyrene micro- and nanoplastics aggravates colitis in a mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
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Researchers found that polystyrene micro- and nanoplastics aggravated colitis symptoms in a mouse model, increasing gut permeability, inflammatory cytokine levels, and tissue damage compared to controls. The study provides mechanistic evidence linking microplastic exposure to worsening of inflammatory bowel conditions.
Polystyrene nanoplastics promote colitis-associated cancer by disrupting lipid metabolism and inducing DNA damage
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In a mouse study, polystyrene nanoplastics accelerated the development of colon cancer linked to inflammatory bowel disease by disrupting fat metabolism and causing DNA damage in intestinal cells. The nanoplastics also altered gut bacteria and increased intestinal inflammation, suggesting that plastic particle exposure could worsen outcomes for people already at risk for colon cancer.
Influence of Microplastics on Manifestations of Experimental Chronic Colitis
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Researchers studied whether consuming microplastics worsens chronic colon inflammation in mice. While microplastics alone did not cause visible damage to healthy intestines, they significantly increased the severity of colitis symptoms, including more ulcers and greater inflammatory cell infiltration, in mice with pre-existing colon inflammation. The findings suggest that microplastic exposure may be particularly concerning for individuals who already have inflammatory bowel conditions.
Polystyrene micro- and nanoplastics in a colitis mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
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Researchers induced colitis in mice using dextran sodium sulfate and orally administered polystyrene micro- and nanoplastics of three sizes, then tracked biodistribution, macrophage polarization, and gut microbiome changes. In colitis conditions, microplastic uptake into systemic tissues was enhanced, macrophages shifted toward a pro-inflammatory phenotype, and gut microbial diversity decreased, suggesting that inflammatory bowel disease increases vulnerability to microplastic-driven systemic harm.
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