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Ecological mixture risk assessment between polystyrene nanoplastic and ivermectin seeking an approach at various trophic levels: bioassays, modeling, and regulatory aspects
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This doctoral thesis examined ecological risks from combined exposure to polystyrene nanoplastics and the antiparasitic drug ivermectin across multiple trophic levels. The research used bioassays and ecological modeling to assess mixture toxicity and its regulatory implications for aquatic organisms in Quebec.
Tese (doutorado) ? Université du Québec à Montréal, Montreal, 2024.
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Microplastics as emerging vectors of combined chemical toxicity: an urgent call for integrative toxicological research
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Tiny plastic particles found in our food, water, and air don't just pose a risk on their own, they can also act like sponges, soaking up other harmful chemicals and carrying them into our bodies. This review paper argues that scientists need to study microplastics and the toxic substances they carry together, rather than separately, to truly understand the health risks. Until that research is done, we won't have a full picture of how these combined exposures might affect things like hormone function, organ health, or disease risk over time.
Co-Exposure of Nanopolystyrene and Other Environmental Contaminants—Their Toxic Effects on the Survival and Reproduction of Enchytraeus crypticus
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This study tested the combined toxicity of nanopolystyrene particles alongside pharmaceuticals, metals, and engineered nanomaterials on the soil worm Enchytraeus crypticus, finding that co-exposure often amplified harm to survival and reproduction beyond that of each pollutant alone. The results highlight that real-world mixtures of plastic and chemical contaminants pose greater ecological risks than single-substance assessments suggest.
Cocktail effects of emerging contaminants on zebrafish: Nanoplastics and the pharmaceutical diphenhydramine
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Researchers investigated cocktail effects of polystyrene nanoplastics and the antihistamine diphenhydramine on zebrafish, finding that nanoplastics altered the uptake and toxicity of the pharmaceutical, demonstrating the importance of studying contaminant mixtures.
Combined Toxicity of PFAS and Microplastics in Aquatic Ecosystems: Synergistic, Additive, and Antagonistic Interactions
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Researchers reviewed the combined toxicity of PFAS and microplastics in aquatic ecosystems, finding that while synergistic interactions receive the most attention, additive and antagonistic outcomes are also common and depend on PFAS congener, polymer type, particle size, and species—warning against treating synergy as the default response and calling for standardized mixture-based exposure protocols to enable ecologically realistic risk assessment.
Interaction of Pesticides with Nano and Microplastics in Aquatic Systems: Co-toxicity and Remediation Strategies a Review
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Researchers reviewed how microplastics and nanoplastics in aquatic environments adsorb pesticides and act as vectors for combined chemical toxicity, examining interaction mechanisms, co-toxicity effects on aquatic organisms and human health, and evaluating remediation and regulatory strategies.
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