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61,005 resultsShowing papers similar to Lipid-Rich diet protects aquatic vertebrates by reducing polystyrene nanoparticles deposition and alleviating harmful effects from exposure
ClearToxicity of Polystyrene Nanoplastics in the Liver and Intestine of Normal and High-Fat-Diet Juvenile Zebrafish
Researchers exposed juvenile zebrafish to polystyrene nanoplastics combined with a high-fat diet and found that the combination caused gastrointestinal injury and disrupted lipid metabolism. The nanoplastics alone perturbed gut microbiota stability, and the effects were amplified when paired with a high-fat diet. The study suggests that dietary factors may influence the severity of nanoplastic toxicity, highlighting the importance of considering real-world exposure scenarios.
Nanoplastic contamination: Impact on zebrafish liver metabolism and implications for aquatic environmental health
Zebrafish exposed to polystyrene nanoparticles for 28 days showed significant disruptions in liver metabolism, including altered fat processing, signs of inflammation, oxidative stress, and DNA damage. Notably, at lower doses the liver's detox enzymes appeared to break down the nanoplastics themselves, while higher doses overwhelmed these defenses and caused more severe injury.
Transcriptome sequencing and metabolite analysis reveal the toxic effects of nanoplastics on tilapia after exposure to polystyrene
Researchers exposed larval tilapia to polystyrene nanoplastics and then analyzed changes in gene expression and metabolic profiles after a recovery period. They found that nanoplastic exposure disrupted immune-related pathways, energy metabolism, and lipid processing in the fish, with some effects persisting even after exposure ended. The study suggests that nanoplastics can cause lasting metabolic and immune disruptions in freshwater fish.
Combined effects of high-fat diet and polystyrene microplastic exposure on microplastic bioaccumulation and lipid metabolism in zebrafish
Researchers studied how a high-fat diet combined with polystyrene microplastic exposure affects zebrafish, finding that obese fish accumulated significantly more microplastics in their tissues. The high-fat diet disrupted lipid metabolism and created conditions that increased microplastic retention in the body. This suggests that diet and body fat levels may influence how much microplastic accumulates in living organisms, with potential implications for human health.
Vitamin D modulates disordered lipid metabolism in zebrafish (Danio rerio) liver caused by exposure to polystyrene nanoplastics
Researchers found that supplementing zebrafish with vitamin D helped counteract the lipid metabolism disruption caused by nanoplastic exposure. Nanoplastics accumulated in the liver and triggered fat buildup, but a high-vitamin-D diet significantly reduced the number of lipid droplets and restored metabolic balance. The study suggests that adequate vitamin D intake may offer some protective effect against the metabolic harm caused by nanoplastic pollution.
Interactions between intestinal microbiota and metabolites in zebrafish larvae exposed to polystyrene nanoplastics: Implications for intestinal health and glycolipid metabolism
Zebrafish larvae exposed to polystyrene nanoplastics suffered intestinal damage, including inflammation, oxidative stress, and disrupted gut bacteria -- with increases in bacteria linked to gut disease. The nanoplastics also altered metabolism related to sugar and fat processing, suggesting that ingesting these tiny particles could harm digestive health and disrupt how the body processes nutrients.
New insights into the impact of polystyrene micro/nanoplastics on the nutritional quality of marine jacopever (Sebastes schlegelii)
Researchers investigated how polystyrene micro- and nanoplastics affect the nutritional quality of marine jacopever fish (Sebastes schlegelii), finding that nanoplastics reduced nutritional quality more severely than microplastics. Despite no notable impact on intestinal microbiota function, both particle types impaired lipid and protein metabolism pathways.
Effects of polystyrene nanoplastics on apoptosis, digestive enzymes, and intestinal histological structure and flora of swamp eel (Monopterus albus)
Researchers exposed swamp eels (Monopterus albus) to polystyrene nanoplastics and found inflammation in the liver and intestine, significant gene expression changes in the liver, and shifts in intestinal microbial community composition toward more pathogenic taxa. The results demonstrate that nanoplastic exposure disrupts apoptosis pathways, digestive enzyme activity, and gut microbiome health in this freshwater fish.
Application of transcriptomic profiling to investigate the toxicity mechanisms caused by dietary exposure of nanoplastics in fish
Researchers used transcriptomic profiling to evaluate the impact of dietary nanoplastic exposure on European sea bass, finding changes in gene expression in intestinal tissue after 21 days of feeding with polystyrene nanoparticle-containing food. The study suggests that while no significant changes were observed in enzymatic stress markers, nanoplastics may trigger subtle molecular-level responses in the fish gut.
Sub-chronic nanoplastic toxicity in Etroplus suratensis (Pisces, Cichilidae): Insights into tissue accumulation, stress and metabolic disruption
Researchers exposed pearl spot fish to polystyrene nanoplastics at different concentrations for 14 days and found that the particles accumulated in multiple organs with concentration-dependent distribution patterns. The nanoplastics caused elevated glucose and cholesterol levels, suppressed antioxidant defenses, and increased markers of oxidative damage and stress. Gene expression changes in stress response and growth-related genes suggest that nanoplastic exposure may impair both immune function and normal development in fish.
Dietary lipid supplementation alleviated the impacts of polystyrene nanoplastic exposure in Litopenaeus vannamei
Researchers demonstrated that increasing dietary lipid levels from 3% to 9% partially counteracts polystyrene nanoplastic toxicity in Pacific white shrimp, improving survival, weight gain, and lipid metabolism gene expression — the first study to show nutritional intervention can mitigate nanoplastic harm in aquaculture.
Comparison of metabolome profiles in zebrafish (Danio rerio) intestine induced by polystyrene microplastics with different sizes
Researchers compared metabolic profiles in zebrafish intestines after exposure to polystyrene microplastics of different sizes, finding that smaller particles caused more severe metabolic disruption including altered lipid metabolism and amino acid pathways in a size-dependent manner.
Transcriptional effects of polyethylene microplastics ingestion in developing zebrafish (Danio rerio)
Researchers exposed developing zebrafish to polyethylene microplastics and used transcriptomic analysis to identify changes in gene expression related to immune function, lipid metabolism, and oxidative stress. The study suggests that even at relatively low concentrations, ingested microplastics can alter key biological pathways during early fish development.
Polystyrene nanoplastics target lysosomes and affect lipid metabolism in RTgutGC and head kidney macrophages from Oncorhynchus mykiss
Researchers investigated the subcellular targets of polystyrene nanoplastics in rainbow trout intestinal cells and head kidney macrophages, finding that PS-NPs co-localized with lysosomes but not mitochondria and did not trigger reactive oxygen species production or alter oxidative metabolism. RNASeq analysis further revealed effects on lipid metabolism pathways, indicating that lysosomal targeting and lipid disruption are key mechanisms of nanoplastic toxicity in fish cells.
Long-Term Exposure to Polystyrene Nanoplastics Impairs the Liver Health of Medaka
Researchers found that three months of exposure to polystyrene nanoplastics caused significant liver damage in medaka fish, including oxidative stress, immune disruption, and altered gene expression related to lipid metabolism and detoxification pathways.
Plastic nanoparticles cause mild inflammation, disrupt metabolic pathways, change the gut microbiota and affect reproduction in zebrafish: A full generation multi-omics study.
Exposure of zebrafish to polystyrene nanoparticles throughout their entire first generation caused mild inflammation, disrupted metabolic pathways, altered gut microbiota, and impaired reproduction — even at environmentally relevant concentrations. This comprehensive multigenerational study demonstrates that nanoplastic exposure can have lasting biological effects across multiple body systems in fish.
Distinctive lipidomic responses induced by polystyrene micro- and nano-plastics in zebrafish liver cells
Researchers compared how micro-sized and nano-sized polystyrene plastic particles affect fat metabolism in zebrafish liver cells. They found that both sizes were taken up by cells, but the smaller nanoplastics caused more pronounced disruptions to lipid profiles and triggered cell death pathways. The findings underscore that particle size matters when assessing the biological impact of plastic pollution on fish.
Particle size-dependent neurotoxicity of microplastics in zebrafish (Danio rerio): Spatially resolved lipidomics links metabolic dysregulation to neurological disorders
Researchers exposed zebrafish to polypropylene microplastics of different sizes and used spatial lipidomic imaging to show size-dependent disruptions in brain lipid metabolism, linking smaller particles to greater neurological disruption and identifying specific lipid dysregulation patterns.
In vivo effects on the immune function of fathead minnow (Pimephales promelas) following ingestion and intraperitoneal injection of polystyrene nanoplastics
Researchers exposed adult fathead minnow to polystyrene nanoplastics via ingestion and intraperitoneal injection and found that both routes delivered particles to liver and kidney and downregulated innate immune genes — including those controlling neutrophil, macrophage, and complement function — suggesting trophic transfer of nanoplastics can compromise fish immune defenses.
Assessing the impact of dietary polystyrene nanoplastics on growth performance, immunological parameters, and antioxidant defense in zebrafish (Danio rerio)
Researchers fed zebrafish diets containing different concentrations of polystyrene nanoplastics for 30 days and observed reduced growth and increased stress markers at higher doses. The study found that nanoplastic exposure triggered oxidative stress, elevated cortisol levels, and altered immune-related gene expression, suggesting potential health impacts on fish from dietary nanoplastic intake.
Transcriptome and Gene Family Analyses Reveal the Physiological and Immune Regulatory Mechanisms of Channa maculata Larvae in Response to Nanoplastic-Induced Oxidative Stress
Researchers exposed larvae of blotched snakehead fish to polystyrene nanoplastics at concentrations ranging from 0.05 to 20 mg/L and observed concentration-dependent damage to the liver and intestines. The nanoplastics triggered oxidative stress responses and affected genes involved in immune regulation and detoxification. The study suggests that nanoplastic pollution during early fish development could compromise both organ function and immune defenses.
Effects of Acute Exposure to Polystyrene Nanoplastics on the Channel Catfish Larvae: Insights From Energy Metabolism and Transcriptomic Analysis
Researchers found that acute exposure to polystyrene nanoplastics disrupted energy metabolism in channel catfish larvae, with transcriptomic analysis revealing altered gene expression in pathways related to oxidative stress and metabolic processes.
Impacts of polystyrene nanoplastics on zebrafish gut microbiota and mechanistic insights
Zebrafish exposed to polystyrene nanoplastics showed significant changes in their gut bacteria, with beneficial species like Bifidobacterium declining and potentially harmful bacteria increasing. The nanoplastics physically entered intestinal tissues, causing visible damage to gut cells. This study is relevant to human health because our gut microbiome plays a key role in immunity and digestion, and similar disruption from nanoplastic exposure could contribute to digestive and immune problems.
Microplastics induce intestinal inflammation, oxidative stress, and disorders of metabolome and microbiome in zebrafish
Researchers exposed zebrafish to polystyrene microplastics for 21 days and found significant intestinal inflammation, oxidative stress, and disruption of both the gut microbiome and metabolic processes. The microplastics altered the balance of beneficial and harmful gut bacteria and changed the levels of key metabolites involved in energy and amino acid metabolism. The study provides detailed evidence that microplastic ingestion can cause widespread disruption to gut health in aquatic organisms.