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20 resultsShowing papers similar to Gut microbiota contributes to polystyrene nanoplastics-induced fetal growth restriction by disturbing placental nicotinamide metabolism
ClearMaternal exposure to polystyrene microplastics alters placental metabolism in mice
Researchers exposed pregnant mice to polystyrene microplastics and examined how placental metabolism was affected. The study found significant changes in placental metabolic pathways that could help explain the fetal growth restriction previously observed in microplastic-exposed pregnancies. These findings suggest that microplastic exposure during pregnancy may interfere with the placenta's ability to support normal fetal development.
Maternal Exposure to Polystyrene Micro- and Nanoplastics Causes Fetal Growth Restriction in Mice
Researchers exposed pregnant mice to polystyrene micro and nanoplastics and found that exposure caused fetal growth restriction and placental abnormalities. The study observed that plastic particles accumulated in placental tissue and disrupted normal placental function. These findings raise concern that maternal exposure to plastic particles during pregnancy may interfere with fetal development.
Polystyrene nanoparticles induced adverse pregnancy outcomes via the activation of placental ferroptosis and gut microbiota dysfunction
Researchers exposed pregnant mice to 50-nanometer polystyrene nanoparticles and found that the particles caused adverse pregnancy outcomes through two interconnected mechanisms: disruption of gut microbiota and activation of ferroptosis in placental tissue. The nanoparticle exposure altered the composition of beneficial gut bacteria and triggered iron-dependent cell death in the placenta. The study suggests that maternal exposure to nanoplastics during pregnancy may threaten reproductive health through gut-placenta axis disruption.
Maternal exposure to polystyrene nanoparticles retarded fetal growth and triggered metabolic disorders of placenta and fetus in mice
Researchers exposed pregnant mice to polystyrene nanoplastics through drinking water and found that higher concentrations led to significantly reduced fetal weight. The nanoplastics caused abnormal cell structures in the placenta and disrupted metabolic processes in both placental tissue and fetal livers. The study suggests that maternal nanoplastic exposure during pregnancy can cross the placental barrier and interfere with normal fetal growth and metabolism.
Intergenerational neurotoxicity of polystyrene nanoplastics in offspring mice is mediated by dysfunctional microbe-gut-brain axis
Researchers found that mother mice exposed to polystyrene nanoplastics during pregnancy and nursing passed neurological harm to their offspring, with the babies showing brain inflammation, disrupted dopamine and serotonin signaling, and gut microbiome imbalances — suggesting that nanoplastic exposure before birth can damage the developing brain through the gut-brain connection.
Maternal nanoplastic ingestion induces an increase in offspring body weight through altered lipid species and microbiota
Researchers found that when mother mice ingested nanoplastics derived from polystyrene and polypropylene during pregnancy and nursing, their offspring showed increased body weight gain. The weight changes were associated with alterations in fat metabolism and shifts in gut microbiome composition in the pups. The study suggests that maternal exposure to nanoplastic pollution may act as an environmental factor contributing to weight gain in offspring.
Maternal exposure to polystyrene nanoplastics impacts developmental milestones and brain structure in mouse offspring
Researchers exposed pregnant mice to polystyrene nanoplastics and studied the effects on their offspring's brain development. The study found that maternal nanoplastic exposure affected developmental milestones and brain structure in the young mice. The findings suggest that nanoplastic exposure during pregnancy may pose risks to fetal brain development, though more research is needed to understand the implications for humans.
Maternal exposure to polystyrene nanoplastics alters fetal brain metabolism in mice
When pregnant mice drank water containing polystyrene nanoplastics at low concentrations, their unborn pups showed significant changes in brain chemistry, including a 40% drop in GABA (a key brain chemical) and a 30% drop in glucose levels. These metabolic disruptions in the fetal brain could help explain the structural brain changes previously seen in pups born to nanoplastic-exposed mothers. This study raises concerns that nanoplastic exposure during pregnancy could affect fetal brain development in humans.
Maternal Polystyrene Microplastic Exposure during Gestation and Lactation Altered Metabolic Homeostasis in the Dams and Their F1 and F2 Offspring
Researchers exposed pregnant mice to polystyrene microplastics during pregnancy and nursing and found significant metabolic disruptions in both the mothers and their offspring across two generations. The microplastics altered lipid metabolism, gut microbiota composition, and key metabolic signaling pathways. The study suggests that microplastic exposure during critical developmental windows may have lasting health consequences that pass to future generations.
Polystyrene nanoplastics disrupt the intestinal microenvironment by altering bacteria-host interactions through extracellular vesicle-delivered microRNAs
Researchers found that polystyrene nanoplastics disrupt the gut lining in mice by altering tiny RNA molecules that control the production of protective proteins in the intestinal barrier. The nanoplastics also caused an imbalance in gut bacteria, creating a chain reaction where damaged gut cells release particles that further weaken the intestinal barrier and change the microbiome.
Maternal polystyrene nanoplastics exposure during pregnancy induces obesity development in adult offspring through disrupting lipid homeostasis
Researchers found that maternal inhalation exposure to polystyrene nanoplastics during pregnancy induced obesity development in adult offspring of mice, suggesting in utero exposure to airborne nanoplastics programs metabolic dysfunction. The study linked prenatal nanoplastic exposure to increased adiposity and metabolic changes persisting into adulthood.
Early-life exposure to polystyrene micro- and nanoplastics disrupts metabolic homeostasis and gut microbiota in juvenile mice with a size-dependent manner
Pregnant mice given polystyrene micro or nanoplastics in their drinking water passed the particles to their pups through the placenta and breast milk, with smaller nanoplastics accumulating more heavily in organs. The nanoplastics (0.05 micrometers) caused more severe gut damage, liver dysfunction, and metabolic disruption in the young mice than the larger microplastics (5 micrometers). This study demonstrates that early-life exposure to nanoplastics, even before birth, can disrupt development in a size-dependent way, with the smallest particles posing the greatest risk.
Polystyrene micro- and nanoplastics cause placental dysfunction in mice
Pregnant mice exposed to polystyrene micro- and nanoplastics in drinking water showed signs of placental dysfunction, with nanoplastics causing more severe effects than microplastics. Both sizes triggered a brain-sparing response in fetuses, where blood flow is redirected to protect the brain from low oxygen, a sign of fetal distress. These findings suggest that nanoplastic exposure during pregnancy could disrupt normal placental function and potentially affect fetal brain development.
Polystyrene nanoplastics-induced altered glycolipid metabolism in the liver: A comparative study between pregnant and non-pregnant mice
Researchers compared glycolipid metabolism effects of polystyrene nanoplastics in pregnant versus non-pregnant mice, finding that pregnancy amplified hepatic lipid disruption, with both low and high doses impairing fat metabolism and altering glucose regulation more severely during gestation.
Gestational exposure to micro- and nanoplastics leads to poor pregnancy outcomes by impairing placental trophoblast syncytialization
Researchers found that exposing pregnant mice to micro- and nanoplastics led to increased embryo loss, reduced embryonic weight, and smaller placentas. The plastic particles impaired a critical process called syncytialization, where placental cells fuse together to form a functional barrier, by activating a stress-response signaling pathway. The study suggests that prenatal microplastic exposure could disrupt placental development and contribute to poor pregnancy outcomes.
Integrated fecal microbiome and metabolome analysis explore the link between polystyrene nanoplastics exposure and male reproductive toxicity in mice
Researchers exposed mice to polystyrene nanoplastics of different sizes and doses, then analyzed fecal microbiome and metabolome changes alongside reproductive outcomes. The study found that nanoplastic exposure disrupted gut microbiota balance and metabolic pathways, which correlated with reduced sperm count, viability, and testosterone levels. The findings suggest that gut microbiota-metabolite disruption may play an important role in nanoplastic-induced male reproductive toxicity.
Gestational exposure to polystyrene microplastics incurred placental damage in mice: Insights into metabolic and gene expression disorders
This mouse study found that when pregnant mice were exposed to tiny polystyrene microplastics (0.1 micrometers), the particles crossed the placenta and reached fetal livers and brains, causing placental damage and impaired fetal development. Larger microplastics (5 micrometers) were less able to cross the placenta, suggesting that the smallest plastic particles pose the greatest risk during pregnancy.
Gut microbiota combined with metabolome dissects long-term nanoplastics exposure-induced disturbed spermatogenesis
Researchers studied how long-term exposure to nanoplastics affects sperm production in mice by analyzing changes in gut bacteria and metabolic pathways. They found that nanoplastic exposure disrupted spermatogenesis, with amino-modified nanoplastics causing more severe effects than standard polystyrene particles. The study suggests that nanoplastics may harm male reproductive health by altering gut microbiota and lipid metabolism.
Interactions between polystyrene-derived micro- and nanoplastics and the microbiota: a systematic review of multi-omics mouse studies
Researchers systematically reviewed 15 mouse studies and found that exposure to polystyrene micro- and nanoplastics consistently disrupted gut bacteria — reducing beneficial species like Lactobacillus and increasing harmful ones — while also altering metabolic pathways throughout the body. Nanoplastics caused more severe microbiome disruption than larger microplastics, highlighting a serious health concern for humans.
Polystyrene micro-/nanoplastics induced hematopoietic damages via the crosstalk of gut microbiota, metabolites, and cytokines
Researchers exposed mice to polystyrene micro- and nanoplastics and found that the particles caused damage to the blood-forming system through disruption of gut bacteria, metabolic changes, and inflammatory signaling. Smaller nanoplastics caused more severe effects than larger microplastics, altering gut microbial communities and triggering systemic inflammation. The study reveals a previously unknown pathway by which ingested plastic particles may harm the body's ability to produce healthy blood cells.