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20 resultsShowing papers similar to Effects of orally administered polystyrene nanoplastics on reproduction and development in rodents
ClearEffects of polystyrene nanoplastics on the female reproductive system in mice: Implications for ovarian function and follicular development
Researchers exposed female mice to polystyrene nanoplastics orally for 29 days and examined the effects on their reproductive systems. They found that nanoplastic exposure disrupted estrous cycles, impaired follicle development, and altered hormone levels in a dose-dependent manner. The study suggests that nanoplastics, due to their extremely small size, may cross biological barriers and accumulate in reproductive tissues, raising concerns about potential effects on fertility.
Exposure to polystyrene nanoplastics impairs sperm metabolism and pre-implantation embryo development in mice
This study found that male mice given polystyrene nanoplastics by mouth showed significant harm to sperm function and early embryo development, with changes in gene expression that could affect offspring. The findings raise concerns that nanoplastic exposure could impair male fertility and potentially pass harmful effects to the next generation.
Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny
Researchers found that maternal exposure to polystyrene nanoplastics caused brain abnormalities in offspring, demonstrating that nanoplastics can cross maternal barriers and affect neurological development in progeny with implications for developmental toxicology.
Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice
Researchers fed male mice polystyrene nanoplastics of different sizes (25, 50, and 100 nm) for 56 days and found that all sizes reduced fertility and some caused complete infertility. The nanoplastics accumulated in the testes, causing oxidative stress, cell death, and inflammation that damaged sperm and reproductive tissue. This study raises concerns that human exposure to nanoplastics through food and water could contribute to declining male fertility.
Oral exposure to polystyrene nanoplastics altered the hypothalamic–pituitary–testicular axis role in hormonal regulation, inducing reproductive toxicity in albino rats
This study found that oral exposure to polystyrene nanoplastics disrupted the hormone signaling pathway between the brain and testes in male rats, leading to reproductive damage. The nanoplastics interfered with the hormones that regulate sperm production and testicular function. These findings add to growing evidence that nanoplastic exposure through food and water could be a contributing factor to declining male fertility.
Maternal exposure to polystyrene nanoplastics impacts developmental milestones and brain structure in mouse offspring
Researchers exposed pregnant mice to polystyrene nanoplastics and studied the effects on their offspring's brain development. The study found that maternal nanoplastic exposure affected developmental milestones and brain structure in the young mice. The findings suggest that nanoplastic exposure during pregnancy may pose risks to fetal brain development, though more research is needed to understand the implications for humans.
Nanoplastic toxicology following gestational and lactational exposure
This review examines evidence from animal studies showing that polystyrene nanoplastics can cross the placental barrier during pregnancy, accumulate in maternal and offspring organs, and cause widespread toxicity. Reported effects in offspring include reproductive and endocrine disruption, neurodevelopmental abnormalities, cardiovascular damage, and metabolic disorders, with the severity of effects influenced by particle size, dose, and timing of exposure.
[Effects of nanopolystyrene nanoplastic exposure on the development and neurotoxicity of fetal rats during gestation].
Researchers found that gestational exposure to polystyrene nanoplastics in rats caused dose-dependent reductions in fetal body weight, body length, and brain development, with smaller 25 nm particles producing more pronounced neurotoxic effects than 50 nm particles.
Micro-nanoplastics pollution and mammalian fertility: A systematic review and meta-analysis
This meta-analysis of 79 studies across five mammalian species found that micro- and nanoplastics cause reproductive toxicity in a concentration-dependent manner, particularly at high doses. Polystyrene was the most studied polymer, and most research focused on male fertility in mice, leaving a significant gap in knowledge about effects on food-producing animals that could serve as vectors for human exposure.
The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge
Researchers administered polystyrene nanoplastics orally to male rats for five weeks and found significant reductions in testosterone, LH, and FSH levels, sperm DNA damage, altered testicular gene expression, and dose-dependent histological lesions, indicating that nanoplastic exposure disrupts the hormonal axis governing male reproductive function.
Transplacental and lactational transfer of polystyrene nanoplastics leads to long-term ovarian impairment in rat offspring
Researchers found that polystyrene nanoplastics crossed the placental barrier in rats and accumulated in fetal and postnatal ovaries, causing dose-dependent damage to follicle development and ovarian structure. Exposed offspring showed reduced primordial follicle numbers, granulosa cell disorganization, and hormonal imbalances that persisted through postnatal day 60. The study suggests that maternal nanoplastic exposure during pregnancy and lactation may have long-lasting effects on female reproductive development.
Direct and intergenerational effects in reproductive parameters of adult male Wistar rats and their offspring after subchronic exposure to polystyrene nanoplastics
Researchers exposed adult male Wistar rats to 500 nm polystyrene nanoplastics and assessed effects on reproductive parameters and intergenerational outcomes in offspring. PS-NP exposure reduced sperm quality and testosterone levels in exposed males, and some reproductive effects were observed in the next generation, suggesting potential intergenerational reproductive toxicity.
Can Mammalian Reproductive Health Withstand Massive Exposure to Polystyrene Micro- and Nanoplastic Derivatives? A Systematic Review
This systematic review examined how polystyrene micro- and nanoplastics affect reproductive health in mammals. The evidence from animal studies shows these particles can cause oxidative stress, inflammation, and hormonal imbalances in reproductive organs, raising concerns about potential effects on human fertility.
Maternal exposure to polystyrene nanoplastics during gestation and lactation induces hepatic and testicular toxicity in male mouse offspring
Researchers exposed pregnant and nursing mice to polystyrene nanoplastics and studied the effects on their male offspring. The offspring showed reduced body weight, liver damage with inflammation and disrupted sugar metabolism, and testicular harm including decreased sperm counts. The findings suggest that nanoplastic exposure during pregnancy and breastfeeding can cause significant organ damage in the next generation.
Maternal exposure to polystyrene nanoplastics leads to ovotoxicity in female mouse offspring
Researchers exposed pregnant mice to polystyrene nanoplastics throughout mating, pregnancy, and nursing, then examined the ovaries of their female offspring. They found that maternal nanoplastic exposure significantly reduced ovarian weight and follicle numbers in the offspring and lowered the expression of key antioxidant genes. The study suggests that nanoplastic exposure during pregnancy may pose risks to the reproductive development of female offspring.
Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring
When pregnant mice were exposed to nanoplastics during pregnancy and nursing, their female offspring had significantly reduced fertility as adults. The nanoplastics caused premature activation of egg cells in the ovaries and damaged crucial connections between eggs and their supporting cells. This raises concerns that a mother's exposure to nanoplastics could have lasting effects on her daughters' ability to have children.
Exposure to Polystyrene Nanoplastics Compromise Ovarian Reserve Function and Endometrial Decidualization in Early Pregnant Mice
Female mice exposed to polystyrene nanoplastics for 90 days before pregnancy had fewer successful pregnancies, smaller pups, and damaged ovaries with reduced egg counts. The nanoplastics disrupted key reproductive hormones and interfered with the uterine process needed for embryo implantation. This study raises concerns that nanoplastic exposure through food and water could harm female fertility and pregnancy outcomes in humans.
Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny
When pregnant mice were exposed to polystyrene nanoplastics, their offspring showed abnormal brain development including changes in neural stem cell function, altered brain structure, and cognitive problems. The effects were gender-specific, with some deficits appearing more strongly in one sex. This study raises concerns that nanoplastic exposure during pregnancy could increase the risk of neurodevelopmental problems in children.
Effects of nanoplastic exposure during pregnancy and lactation on neurodevelopment of rat offspring
When pregnant and nursing rats were exposed to polystyrene nanoplastics, their offspring showed thinner brain cortexes, disrupted neurotransmitter levels, damaged connections between brain cells, and problems with anxiety and spatial memory. This study suggests that maternal exposure to nanoplastics during pregnancy and breastfeeding could affect brain development in offspring.
Intergenerational and transgenerational reproductive toxicity of polystyrene microplastics in female mice
Female mice were exposed to polystyrene microplastics during lactation and researchers tracked reproductive outcomes in both exposed mothers and their offspring through multiple generations, finding that even at doses comparable to human infant bottle-feeding exposure, microplastics induced ovarian damage and reduced fertility that persisted across generations.