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61,005 resultsShowing papers similar to Arsenic and polystyrene-nano plastics co-exposure induced testicular toxicity: Triggers oxidative stress and promotes apoptosis and inflammation in mice.
ClearCombined exposure to titanium nanoparticles and nanoplastics damages the male reproductive system and sperm activity
This study assessed the effects of combined TiO2 nanoparticles and polystyrene nanoplastics on male reproductive function in animal models, finding that co-exposure caused greater damage to sperm motility, testicular structure, and hormone levels than either material alone. The results raise concerns about combined environmental exposure to two common industrial nanomaterials.
Maternal Exposureto Combined Cadmium and PolystyreneNanoplastics Induces Offspring Testicular Dysplasia via MitochondrialReactive Oxygen Species Overactivating the Peroxisome Proliferator-ActivatedReceptor α‑Mediated Autophagy Signaling Pathway
Maternal exposure to combined polystyrene nanoplastics and cadmium during pregnancy caused testicular dysplasia in offspring via mitochondrial reactive oxygen species overactivating the PPARα-mediated autophagy pathway, with combined exposure more harmful than either alone.
Combined effects of polystyrene nanoplastics and lipopolysaccharide on testosterone biosynthesis and inflammation in mouse testis
Researchers found that polystyrene nanoplastics combined with bacterial toxins (LPS) caused worse damage to mouse testicles than either substance alone, reducing sperm count, lowering testosterone levels, and increasing inflammation. Since microplastics in the environment can carry bacteria and their toxins, this combination exposure is realistic. The findings suggest that nanoplastic pollution could amplify the reproductive harm caused by bacterial infections in males.
Polystyrene nanoplastics aggravate reproductive system damage in obese male mice by perturbation of the testis redox homeostasis
Researchers found that polystyrene nanoplastics worsened reproductive damage in male mice already fed a high-fat diet, reducing sperm quality and testosterone production beyond what obesity alone caused. The nanoplastics disrupted the protective blood-testis barrier and increased oxidative stress in reproductive tissues. The study suggests that nanoplastic exposure combined with obesity may create compounding risks to male fertility.
Nanoplastics and Arsenic Co-Exposures Exacerbate Oncogenic Biomarkers under an In Vitro Long-Term Exposure Scenario
Researchers examined the combined effects of polystyrene nanoplastics and arsenic on oncogenic biomarkers using an in vitro long-term exposure model. The study found that co-exposure to nanoplastics and arsenic exacerbated oncogenic biomarker responses compared to individual exposures. The findings suggest that nanoplastics may act as carriers for arsenic, potentially modulating its uptake and amplifying harmful effects in cellular systems.
Maternal Exposure to Combined Cadmium and Polystyrene Nanoplastics Induces Offspring Testicular Dysplasia via Mitochondrial Reactive Oxygen Species Overactivating the Peroxisome Proliferator-Activated Receptor α-Mediated Autophagy Signaling Pathway
Researchers investigated the combined effects of maternal exposure to polystyrene nanoplastics and cadmium on offspring in a mouse model. The study found that co-exposure caused testicular developmental abnormalities in offspring through mitochondrial oxidative stress and disrupted autophagy signaling, suggesting that nanoplastics may amplify the reproductive toxicity of co-occurring environmental contaminants.
Polystyrene nanoparticles enhance the adverse effects of di-(2-ethylhexyl) phthalate on male reproductive system in mice
Researchers investigated the combined reproductive toxicity of polystyrene nanoparticles and the plasticizer DEHP in male mice over 35 days. The study found that co-exposure to nanoparticles and DEHP produced enhanced adverse effects on sperm quality and testicular tissue compared to either substance alone, suggesting nanoplastics may amplify the endocrine-disrupting effects of plasticizers.
Combined effect of polystyrene nanoplastic and di-n-butyl phthalate on testicular health of male Swiss albino mice: analysis of sperm-related parameters and potential toxic effects
This mouse study found that combined exposure to polystyrene nanoplastics and a common plasticizer chemical (DBP) caused worse damage to male reproductive health than either substance alone. The combination significantly reduced sperm quality, lowered antioxidant defenses, and damaged testicular tissue over 60 days. These findings are concerning because people are often exposed to both nanoplastics and plasticizer chemicals at the same time through food packaging and everyday products.
Combined effect of arsenic and polystyrene-nanoplastics at environmentally relevant concentrations in mice liver: Activation of apoptosis, pyroptosis and excessive autophagy
Researchers investigated the combined toxic effects of arsenic and polystyrene nanoplastics on mouse liver at environmentally relevant concentrations. The study found that co-exposure activated multiple cell death pathways including apoptosis, pyroptosis, and excessive autophagy in liver tissue, suggesting that the interaction between nanoplastics and heavy metals may amplify liver damage.
Toxic effects of co-exposure to polystyrene nanoplastics and arsenic in zebrafish (Danio rerio): Oxidative stress, physiological and biochemical responses
In a zebrafish study, polystyrene nanoplastics made arsenic more toxic by helping the poison build up in the liver, gills, and intestines. The nanoplastics increased cell damage and oxidative stress beyond what arsenic alone would cause. This shows that nanoplastics can act as carriers for other toxic substances in water, potentially making environmental pollutants more dangerous to aquatic life and the food chain.
The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge
Researchers administered polystyrene nanoplastics orally to male rats for five weeks and found significant reductions in testosterone, LH, and FSH levels, sperm DNA damage, altered testicular gene expression, and dose-dependent histological lesions, indicating that nanoplastic exposure disrupts the hormonal axis governing male reproductive function.
Co-exposure to polystyrene nanoplastics and hexachlorocyclohexane induces enhanced human sperm toxicity in vitro
Scientists found that when human sperm are exposed to both tiny plastic particles (nanoplastics) and a pesticide chemical at the same time, it causes much more damage than either substance alone. The combination severely reduced sperm's ability to swim and function properly, which could contribute to male fertility problems. This suggests that the growing presence of microplastics in our environment might make other harmful chemicals even more dangerous to reproductive health.
Co-exposure of cadmium and polystyrene nanoplastics: Induction pyroptosis and autophagy in mice testis
Researchers investigated the combined effects of cadmium and polystyrene nanoplastics on mouse testicular tissue. The study found that co-exposure produced more severe testicular damage than either substance alone, driven by the interplay between pyroptosis (inflammatory cell death) and autophagy. Inhibiting one of these cellular processes affected the other, suggesting they are closely interconnected in the toxicity response to nanoplastic and heavy metal co-exposure.
Integration of physiology, microbiota and metabolomics reveals toxic response of zebrafish gut to co-exposure to polystyrene nanoplastics and arsenic
Researchers exposed zebrafish to arsenic combined with polystyrene nanoplastics and found that the nanoplastics significantly increased arsenic accumulation in the gut, by up to 77% at the higher dose. The combined exposure caused more oxidative damage and greater disruption to gut bacteria and metabolism than arsenic alone. This study shows that nanoplastics can make other environmental pollutants more dangerous by helping them accumulate in the digestive system.
Polystyrene nanoplastics aggravated dibutyl phthalate-induced blood-testis barrier dysfunction via suppressing autophagy in male mice
In a mouse study, polystyrene nanoplastics combined with dibutyl phthalate (a common plasticizer chemical) caused significantly worse damage to the blood-testis barrier than either substance alone. The nanoplastics carried the phthalate into the reproductive system, where the combination reduced sperm quality, impaired sperm development, and damaged the protective barrier around the testes. This research shows how nanoplastics can make other common plastic chemicals more dangerous to male fertility.
Polystyrene microplastic exposure in mice: oxidative stress-induced testicular damage, AR gene suppression, and histopathological alterations
Researchers exposed mice to polystyrene microplastics at two different concentrations and observed significant impacts on reproductive health, including increased oxidative stress in testicular tissue. The study found elevated reactive oxygen species, reduced sperm count and motility, and suppression of androgen receptor gene expression. Evidence indicates that microplastic exposure may pose reproductive health risks by disrupting antioxidant defenses and damaging testicular cells.
Reproductive toxicity and transgenerational effects of co-exposure to polystyrene microplastics and arsenic in zebrafish
This zebrafish study found that combined exposure to polystyrene microplastics and arsenic caused more severe reproductive damage than either pollutant alone, including abnormal egg development and disrupted hormone levels. The toxic effects were passed down to the next generation, even though offspring were not directly exposed. Since microplastics can carry arsenic and other heavy metals in the environment, their combined effects on fertility may be worse than studies of individual pollutants suggest.
Combined effect of polystyrene microplastics and cadmium on rat blood-testis barrier integrity and sperm quality
Researchers exposed male rats to polystyrene microplastics and cadmium, both separately and together, and found that both substances damaged testicular tissue, disrupted the blood-testis barrier, and reduced sperm quality. Notably, the combined exposure was less severe than cadmium alone, likely because microplastics absorbed some cadmium in the gut and reduced its bioavailability. The study also found for the first time that microplastics trigger autophagy in reproductive cells as a protective response.
Co-exposure of arsenic and polystyrene-nanoplastics induced kidney injury by disrupting mitochondrial homeostasis and mtROS-mediated ferritinophagy and ferroptosis
Researchers found that arsenic and polystyrene nanoplastics together — but not separately — cause kidney fibrosis in mice by disrupting mitochondrial function and triggering a form of iron-dependent cell death called ferroptosis, with mitochondria-targeted antioxidants significantly reducing the combined damage.
Nanoplastics and Arsenic Co-Exposures Exacerbate Oncogenic Biomarkers Under an in Vitro Long-Term Exposure Scenario
This lab study examined whether nanoplastics combined with arsenic — a naturally occurring toxic element — had greater cancer-promoting effects than either contaminant alone. The combination worsened multiple cancer-related biomarkers in human cells over long-term exposure. The findings raise concerns about the health consequences of nanoplastic exposure in environments where multiple pollutants are present simultaneously.
Chemical Cocktail: Understanding PSNP and DBP Impact on Testicular Health of Swiss albino mice
A 60-day study in male mice found that polystyrene nanoplastics and the common plasticizer di-n-butyl phthalate (DBP) each impaired sperm quality and testicular structure, but combining the two caused even greater damage — including tubular degeneration, oxidative stress, and structural lesions — than either substance alone. This suggests that real-world simultaneous exposures to nanoplastics and chemical additives they carry could pose compounded reproductive health risks.
The crosstalk between M1 macrophage polarization and energy metabolism disorder contributes to polystyrene nanoplastics-triggered testicular inflammation
Researchers investigated how polystyrene nanoplastics cause testicular inflammation in mice by studying the interplay between immune cell behavior and energy metabolism. They found that nanoplastics triggered a pro-inflammatory immune response involving M1 macrophage activation, disrupted cellular energy processes, and caused testicular tissue damage. The study reveals a specific biological mechanism by which nanoplastic exposure may impair male reproductive health.
Nanoplastics aggravate the toxicity of arsenic to AGS cells by disrupting ABC transporter and cytoskeleton
Researchers investigated how polystyrene nanoplastics of various sizes affect the toxicity of arsenic in human gastric cells. They found that while nanoplastics alone at noncytotoxic concentrations did not harm cells, they significantly enhanced arsenic accumulation and toxicity by disrupting cell membrane integrity, damaging the cytoskeleton, and inhibiting ABC transporter activity. The study highlights that nanoplastics can aggravate the harmful effects of co-occurring environmental contaminants even at concentrations previously considered safe.
Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice
Researchers fed male mice polystyrene nanoplastics of different sizes (25, 50, and 100 nm) for 56 days and found that all sizes reduced fertility and some caused complete infertility. The nanoplastics accumulated in the testes, causing oxidative stress, cell death, and inflammation that damaged sperm and reproductive tissue. This study raises concerns that human exposure to nanoplastics through food and water could contribute to declining male fertility.