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61,005 resultsShowing papers similar to Further studies in translatable model systems are needed to predict the impacts of human microplastic exposure.
ClearFurther Studies in Translatable Model Systems are Needed to Predict the Impacts of Human Microplastic Exposure
This review highlights that humans are inevitably exposed to microplastics through food, drink, and air, but most toxicity studies have been done in aquatic species at unrealistically high doses. The authors call for better experimental models that reflect realistic human exposure before health risks can be fully assessed.
Potential adverse health effects of ingested micro- and nanoplastics on humans. Lessons learned from in vivo and in vitro mammalian models
This review compiles recent studies on the effects of ingested micro- and nanoplastics using mammalian in vivo and in vitro models to assess potential human health implications. The authors found that while substantial research effort has been made, significant gaps remain in understanding absorption, biodistribution, and toxicity of these particles in mammalian systems. The review provides recommendations for improved testing methods to generate more relevant and targeted data for human risk assessment.
Can the impact of micro- and nanoplastics on human health really be assessed using in vitro models? A review of methodological issues
This review examines whether lab-based cell studies can reliably predict how micro and nanoplastics affect human health. The authors found significant inconsistencies in how researchers choose plastic particle types, doses, and exposure methods, making it hard to compare results across studies. The paper calls for standardized testing protocols so that lab findings can more accurately reflect real-world microplastic exposure risks to people.
Microplastics and Human Health: A Comprehensive Review on Exposure Pathways, Toxicity, and Emerging Risks
This comprehensive review examines microplastic exposure pathways in humans, methods of detection, and the potential toxic effects on various biological systems. The study highlights growing evidence that microplastics can enter the body through ingestion, inhalation, and dermal contact, and may affect multiple organ systems, though significant uncertainties remain about long-term health outcomes.
Hazard assessment of small-size plastic particles: is the conceptual framework of particle toxicology useful?
Researchers reviewed the toxicological evidence for micro- and nanoplastic hazards using a particle toxicology framework, finding that most cell culture studies show effects only at high concentrations and that animal studies have not demonstrated overt toxicity — while concluding that realistic low-dose studies using tissue models that mimic mammalian architecture are urgently needed to properly assess human health risk.
Harmful effects of the microplastic pollution on animal health: a literature review
This review summarizes research on how microplastics affect the health of both aquatic organisms and lab animals like mice and rats. The animal studies suggest that microplastics could have a significant negative impact on human health, but the results are still mixed because experiments vary widely in plastic type, particle size, and dosage. More standardized research is needed before we can draw firm conclusions about the risks to people.
Microplastic toxicity: mechanisms, assessment methods, and future research directions
This review synthesizes current knowledge on microplastic toxicity mechanisms, integrating physical, chemical, and biological pathways into a unified framework. Researchers examined assessment methods across aquatic organisms, terrestrial species, and human cell models, identifying critical knowledge gaps and recommending standardized approaches for future microplastic toxicity research.
Animal exposure to microplastics and health effects: A review
Researchers reviewed how microplastic exposure affects animals across terrestrial and aquatic environments, finding that species suffer physical harm, chemical contamination from pollutants that stick to plastic surfaces, inflammation, and behavioral changes. Because microplastics accumulate up the food chain, the review warns that animals entering the human food supply may carry these particles into our bodies.
Recent progress of microplastic toxicity on human exposure base on in vitro and in vivo studies
This review summarizes recent research on how microplastics affect the human body based on lab cell studies and animal experiments. Evidence shows microplastics can damage multiple organ systems including the digestive, respiratory, nervous, reproductive, and cardiovascular systems. The paper identifies significant gaps in our understanding and calls for more research using realistic exposure levels to better assess the true risk to human health.
Exposure scenarios for human health risk assessment of nano- and microplastic particles
This paper focuses on developing realistic exposure scenarios for assessing human health risks from nano- and microplastic particles. Establishing accurate models of how much plastic people actually encounter through food, air, and water is a critical step for determining whether current exposure levels pose real health dangers.
Environmental exposure to microplastics: a scoping review on human health effects
This scoping review systematically examined published evidence on the health effects of microplastic exposure in humans. It found that human exposure is certain and widespread, but that data on dose-response relationships and specific health outcomes are still limited — highlighting an urgent need for rigorous human health studies.
Human Toxicity of Nano‐ and Microplastics
This review summarizes current evidence on the human toxicity of nano- and microplastics, covering ingestion, inhalation, and dermal exposure routes and the biological effects documented in experimental systems. The authors assess the state of the evidence and identify key gaps for risk characterization.
Impact of Microplastics on Aquatic Organisms and Human Health: A Review
This review examined the impacts of microplastics on aquatic organisms and human health, highlighting that microplastic size ranges mimic prey sizes ingested by aquatic organisms and that contaminated commercially important fish species transfer microplastics to human consumers. The authors synthesised evidence on ingestion pathways, toxicological effects, and human dietary exposure routes.
Microplastics: Impacts on the Environment and Human Health
This review covers what is currently known about microplastic pollution's effects on both the environment and human health, summarizing evidence from studies on wildlife, ecosystems, and human exposure pathways. The authors note that while concern is growing, definitive conclusions about human health risks remain elusive due to limited clinical research.
Microplastics toxicity: Classification, sources, exposure routes, and experiments
This review summarized the classification, sources, exposure routes, and toxicological effects of microplastics across environmental matrices and biological systems. The authors synthesized evidence from multiple exposure experiments to assess human health risks from ingestion, inhalation, and dermal contact with common plastic polymers.
Microplastic Exposure and Human Health: Advancing Risk Assessment and Future Research Directions
This review synthesizes recent evidence that microplastics are present in human blood, respiratory tissue, placenta, and gut, examines proposed toxicological mechanisms, and identifies priorities for improving risk assessment frameworks and exposure measurement methods.
Health impacts and detection challenges of human exposure to microplastics
This review examined the health impacts of human exposure to microplastics and nanoplastics through ingestion, inhalation, and skin absorption. Researchers found that these tiny particles pose significant health risks due to their ability to carry toxic contaminants and interact with biological tissues. The study also highlights major challenges in accurately detecting and measuring microplastic exposure in humans, which limits our understanding of the full scope of health effects.
Impact of microplastics and nanoplastics on human Health: Emerging evidence and future directions
This review summarizes current evidence on how micro- and nanoplastics enter the human body through food, air, and skin contact, and the cellular damage they may cause. While microplastic pollution is a recognized environmental hazard, the authors note that definitive evidence linking plastic particle exposure to specific health outcomes in humans is still limited and more realistic exposure studies are needed.
Paradigms to assess the human health risks of nano- and microplastics
Researchers proposed a new, comprehensive framework for assessing the health risks of nano- and microplastics (tiny plastic particles), addressing key gaps in how we analyze these particles, model their behavior, and use that information to protect human health — since no such standard risk assessment system currently exists.
The Need to Implement Innovative Technologies to Advance Research on the Biotoxicity of Micro- and Nanoplastics
This review examines the limitations of current animal models for studying the biotoxicity of micro- and nanoplastics and argues for the adoption of innovative technologies such as organoids, organ-on-chip platforms, and advanced imaging. It calls for mechanistic studies that move beyond descriptive toxicity characterisation.
A critical viewpoint on current issues, limitations, and future research needs on micro- and nanoplastic studies: From the detection to the toxicological assessment.
This critical review examines the current methods for detecting and characterizing micro- and nanoplastics in various environmental samples, as well as reported toxic effects from in vivo and in vitro studies. The authors found that while substantial effort has been made to understand microplastic behavior, the scientific community is still far from a complete understanding of how these particles behave in biological systems. The review calls for improved standardized protocols and more studies focused on uptake kinetics, accumulation, and biodistribution.
A One Health perspective of the impacts of microplastics on animal, human and environmental health
This review takes a "One Health" approach to microplastics, examining how they affect animal health, human health, and the environment as interconnected systems. The authors caution that many lab studies use microplastic concentrations far higher than what is found in nature, making their results hard to apply to real-world risk. However, they note that microplastics can indirectly affect human health by disrupting ecosystems and soil processes that support food production and clean water.
The need for ecologically realistic studies on the health effects of microplastics
This perspective argues that current laboratory studies on microplastic health effects — which rely on force-feeding rodents unrealistically high doses — poorly represent actual wildlife or human exposures, calling for more ecologically realistic study designs to generate meaningful risk data.
Multiple Effects, Pathways, and Potential Health Risks from Environmental Microplastic Exposure
This review synthesizes nearly two decades of research on the multiple pathways through which environmental microplastics affect human and ecological health, including chemical toxicity, physical impacts, and potential roles as carriers of pathogens and contaminants.