We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
61,005 resultsShowing papers similar to Serum Glutamic Oxalacetic Transaminase Activity as an Index of Liver Cell Injury: a Preliminary Report
ClearEvaluation of Liver Function Through SGOT and SGPT Quantification in Rats Administered Polyethylene Terephthalate Microplastics
Researchers administered PET microplastics orally to white rats at doses of 0.4–1.0 mg/day and measured SGOT and SGPT liver enzyme levels, finding dose-dependent increases in both transaminases indicating hepatotoxicity even at low exposure levels.
Correlation Between Tumor Differentiation and Biomarkers in Hepatocellular Carcinoma: Implications for Early Diagnosis and Treatment
Researchers examined the correlation between tumor differentiation levels and biomarker expression in patients with hepatocellular carcinoma. The study found significant associations between tumor grade and certain biomarker levels, suggesting these markers may have potential value for early diagnosis and treatment planning in liver cancer.
Heavy Metals, Halogenated Hydrocarbons, Phthalates, Glyphosate, Cordycepin, Alcohol, Drugs, and Herbs, Assessed for Liver Injury and Mechanistic Steps
This review assesses liver injury mechanisms from a wide range of hepatotoxicants including heavy metals, phthalates, glyphosate, alcohol, drugs, and herbs, providing a toxicology framework to help physicians identify the cause of liver damage.
Comprehensive Transcriptome Profiling of Antioxidant Activities by Glutathione in Human HepG2 Cells
Researchers used DNA microarray analysis to map the full range of genes activated by the antioxidant glutathione in human liver cells under both normal and stressed conditions. They found that glutathione activates protective antioxidant pathways, including the NRF2 system, and regulates a broad set of biological processes beyond its known role. The study provides a comprehensive molecular picture of how glutathione supports liver cell defense against oxidative damage.
Fish liver damage related to the wastewater treatment plant effluents
Researchers reviewed how the complex chemical mixture discharged by wastewater treatment plants damages fish liver structure and function, examining how biotransformation enzymes and antioxidant systems attempt to cope with persistent contaminants and highlighting fish biomarkers used to detect exposure.
Potential toxicity of microplastics on vertebrate liver: A systematic review and meta–analysis
This meta-analysis of 118 studies found that microplastics damage vertebrate livers by inducing oxidative stress and intracellular toxicity, altering biotransformation processes, and disrupting lipid metabolism. Organisms at earlier life stages, exposed to smaller particles, and for longer durations showed the greatest liver damage, with catalase, GST, reactive oxygen species, and alkaline phosphatase levels progressively increasing with microplastic concentration.
Alkaline phosphatase activity as a biochemical biomarker in aqua-toxicological studies
This review covers the use of alkaline phosphatase (ALP) as a biochemical biomarker in aquatic toxicology studies, explaining its role in cellular metabolism and how ALP activity changes in response to pollutant exposure, hormonal shifts, and nutritional status. ALP is presented as a practical indicator of hepatic function and detoxification activity in aquatic organisms.
Microplastic-mediated new mechanism of liver damage: From the perspective of the gut-liver axis
This review describes how microplastics can damage the liver through the gut-liver axis: they first disrupt the gut's protective barrier and beneficial bacteria, allowing harmful substances to leak through the weakened intestinal wall into the bloodstream and travel to the liver. Once there, these substances cause inflammation, metabolic problems, and oxidative stress, offering a new explanation for how microplastic exposure could lead to liver disease.
The Effect of Peroral Polyvinyl Chloride Microplastic on Alkaline Phosphatase and Gamma-glutamyl Transferase Levels in Rattus Norvegicus Wistar Strain
Researchers found that Wistar rats administered 0.5 mg/day of polyvinyl chloride microplastics orally showed altered alkaline phosphatase and gamma-glutamyl transferase levels compared to controls, providing experimental evidence that oral PVC microplastic exposure can disrupt liver enzyme function.
Identification and validation of novel signature associated with hepatocellular carcinoma prognosis using Single-cell and WGCNA analysis
This study identified a novel gene signature associated with hepatocellular carcinoma using TCGA datasets and validated key molecular targets with potential prognostic and therapeutic significance. The findings advance understanding of the molecular mechanisms driving liver cancer progression.
Palliative effect of taurine against hepatic injury induced by polystyrene microplastics through antioxidant and metabolic pathway modulation in mice
Researchers found that polystyrene microplastics caused liver damage in an animal model through oxidative stress and lipid metabolic disruption, and that taurine supplementation exerted a protective effect by modulating oxidative and metabolic pathways. The results support taurine as a potential therapeutic agent for microplastic-induced hepatotoxicity.
Acute Exposure of Upcyte® Hepatocytes to Sub-lethal Concentrations of Graphene Oxide: Impairment of Phase-I Xenobiotic Metabolism and Albumin Transcription
This study assessed whether graphene oxide nanoparticles harm liver cell function in a human cell model, finding they impair drug metabolism enzymes and protein production at sub-lethal doses. While focused on a nanomaterial used in medicine, the findings are relevant to understanding how any nano-scale particle exposure can affect liver health.
Hepatoprotective Effect of Allium ochotense Extracts on Chronic Alcohol-Induced Fatty Liver and Hepatic Inflammation in C57BL/6 Mice
Researchers tested extracts from the plant Allium ochotense for their ability to protect against alcohol-induced liver damage in mice. The study found that the extracts improved lipid metabolism, reduced liver inflammation, and boosted antioxidant defenses, suggesting potential as a natural approach to supporting liver health in the context of chronic alcohol consumption.
Dimethyl Bisphenolate Ameliorates Carbon Tetrachloride-Induced Liver Injury by Regulating Oxidative Stress-Related Genes
Researchers synthesized a novel compound called dimethyl bisphenolate and tested its ability to protect against chemically induced liver injury in rats and cell models. They found that the compound significantly reduced liver damage markers and oxidative stress in a dose-dependent manner, with effects comparable to the established liver protectant silymarin. The study suggests that dimethyl bisphenolate may help protect liver cells by regulating oxidative stress pathways and reducing cell death.
Hazards of microplastics exposure to liver function in fishes: A systematic review and meta-analysis
This meta-analysis found that microplastic exposure significantly impairs fish liver function, elevating key liver enzymes (AST, ALT, ALP, LDH) and triggering oxidative stress markers in liver tissue. The toxicological mechanisms include inflammation, apoptosis, and metabolic disruption, raising concerns about the health of fish populations in microplastic-contaminated waters and the safety of fish as a human food source.
Mechanism of Pyroptosis in Acute Liver Injury and Prospect of Targeted Therapy
This review examined the role of pyroptosis—an inflammatory form of programmed cell death—in acute liver injury, covering the gasdermin-mediated molecular mechanisms involved. The authors proposed that targeting pyroptosis pathways may offer new therapeutic strategies for conditions such as drug-induced liver injury and ischemia-reperfusion damage.
Association of strontium exposure with liver function: A cross-sectional study from a mining area in Hunan, China
Researchers conducted a cross-sectional study of 1,021 residents from a mining area in Hunan Province, China, measuring plasma strontium, lead, and other metal concentrations alongside serum ALT, AST, and total bilirubin levels to examine both single and combined effects of strontium exposure on liver function.
Protective effects of herbacetin against polystyrene microplastics-instigated liver damage in rats
Researchers investigated the protective effects of herbacetin, a natural flavonoid, against liver damage caused by polystyrene microplastic exposure in rats. The study found that herbacetin helped restore antioxidant enzyme levels and reduce inflammation markers, suggesting it may offer some protection against microplastic-associated oxidative stress in liver tissue.
The double-edged role of hydrogen sulfide in the pathomechanism of multiple liver diseases
This review examined the double-edged role of hydrogen sulfide (H2S) as a gaseous signaling molecule across multiple liver disease conditions, summarizing its protective antioxidant and anti-inflammatory effects alongside its potential to exacerbate damage at higher concentrations. The findings suggest context-dependent therapeutic windows for H2S modulation in liver disease.
Identifying biomarkers of pollutant exposure in ocean sentinels: Characterisation and optimisation of B-esterases in plasma from loggerhead turtles undergoing rehabilitation
Researchers characterized B-esterases in blood plasma from 69 loggerhead sea turtles undergoing rehabilitation, finding that these enzymes can serve as biomarkers of exposure to organophosphate and carbamate contaminants, supporting the use of turtles as ocean health sentinels.
Nanoplastics and Microplastics May Be Damaging Our Livers
This systematic review summarizes research on how micro- and nanoplastics may damage the liver. Since the liver is the body's main detoxification organ, it plays a key role in processing plastic particles that enter the body through food, water, and air, and the evidence suggests these particles can cause inflammation, oxidative stress, and other liver problems.
Hepatic multi-level responses to polyethylene microplastics in Lateolabrax maculatus: Insights from transcriptomics, antioxidant enzyme activity, and histopathology
Researchers exposed spotted sea bass to diets containing polyethylene microplastics for 45 days and found multiple levels of liver damage, including altered gene expression, reduced antioxidant enzyme activity, and visible tissue changes. A subsequent depuration period showed partial but incomplete recovery. The study suggests that chronic microplastic exposure through contaminated feed may pose significant risks to liver health in commercially farmed fish species.
Impact of microplastics exposure on liver health: A comprehensive meta-analysis
This meta-analysis of 70 studies across mice, fish, crabs, and shrimp found that microplastic exposure significantly increases liver enzymes (ALT, AST), oxidative stress marker MDA, and pro-inflammatory cytokines (IL-6, TNF-alpha), while reducing protective antioxidant enzymes (SOD, CAT, GSH, GPx). The findings demonstrate that microplastics disrupt liver function through oxidative stress and inflammation across multiple animal species.
Predicting Valproate-Induced Liver Injury Using Metabolomic Analysis of Ex Ovo Chick Embryo Allantoic Fluid
This paper is not about microplastics; it evaluates chick embryo allantoic fluid metabolomics as a model for predicting drug-induced liver injury from valproate.