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Palliative effect of taurine against hepatic injury induced by polystyrene microplastics through antioxidant and metabolic pathway modulation in mice

Frontiers in Pharmacology 2025 2 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 48 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Areej A. Eskandrani, Amany Abdel-Rahman Mohamed, Badriyah S. Alotaibi, Yasmina M. Abd‐Elhakim, Tarek Khamis, Ahmed E. Noreldin, Ahmed E. Abdelhamid, Nawal Alsubaie, Nawal Alsubaie, Leena S. Alqahtani

Summary

Researchers found that polystyrene microplastics caused liver damage in an animal model through oxidative stress and lipid metabolic disruption, and that taurine supplementation exerted a protective effect by modulating oxidative and metabolic pathways. The results support taurine as a potential therapeutic agent for microplastic-induced hepatotoxicity.

Polymers
Body Systems
Models

Overall, the findings indicated that PS-MPs caused liver damage via oxidative stress and lipid metabolic disturbance, and that Tau supplementation had a protective effect, possibly via modulating oxidative and metabolic pathways. This experiment emphasized the necessity for additional research into Tau as a therapeutic agent in microplastic-related liver damage.

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