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Palliative effect of taurine against hepatic injury induced by polystyrene microplastics through antioxidant and metabolic pathway modulation in mice
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Researchers found that polystyrene microplastics caused liver damage in an animal model through oxidative stress and lipid metabolic disruption, and that taurine supplementation exerted a protective effect by modulating oxidative and metabolic pathways. The results support taurine as a potential therapeutic agent for microplastic-induced hepatotoxicity.
Overall, the findings indicated that PS-MPs caused liver damage via oxidative stress and lipid metabolic disturbance, and that Tau supplementation had a protective effect, possibly via modulating oxidative and metabolic pathways. This experiment emphasized the necessity for additional research into Tau as a therapeutic agent in microplastic-related liver damage.
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Table 1_Palliative effect of taurine against hepatic injury induced by polystyrene microplastics through antioxidant and metabolic pathway modulation in mice.docx
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This study investigated the molecular mechanisms underlying liver toxicity caused by polystyrene microplastics, finding that PS-MPs accumulated in hepatic tissues and disrupted lipid metabolism through oxidative stress and inflammatory signaling. The results mapped specific molecular pathways through which microplastics impair liver function.
Protective effects of taurine against microplastic-induced nephrotoxicity through suppression of oxidative stress, NF-κB/Caspase-3 activation, and pro-fibrotic signaling
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Researchers exposed mice to oral polystyrene microplastics for 60 days and documented kidney damage through oxidative stress, inflammation, apoptosis, and fibrosis, then showed that taurine supplementation could substantially reverse these effects by restoring antioxidant defenses and suppressing pro-inflammatory signaling pathways.
Polystyrene microplastics impact on cardiac and pulmonary physiology and microenvironment in a mouse model: Role of taurine supplementation and molecular docking insights
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Researchers investigated the effects of polystyrene microplastics on heart and lung tissues in mice and found that exposure disrupted antioxidant defenses, increased lipid peroxidation, and elevated cardiac injury markers and pro-inflammatory cytokines. Microplastic exposure also upregulated inflammatory and pyroptotic gene expression in both tissues. Co-administration of taurine significantly ameliorated these alterations, suggesting it may offer protective effects against microplastic-induced cardiopulmonary damage.
Taurine attenuates polystyrene microplastic–associated oxidative stress, inflammation, and apoptotic changes in the spleen of mice
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Mice exposed to microplastics showed damage to their spleen (a key immune organ), including increased inflammation, cell stress, and cell death—but the amino acid taurine, a common supplement ingredient, helped protect against much of this damage. While this is animal research and more studies are needed before we know if it applies to humans, it hints that a cheap, widely available nutrient might one day help offset some health risks from the microplastics we're increasingly exposed to in daily life.
Taurine improves bovine oocyte maturation through recovering mitochondrial dysfunction and oxidative stress-induced apoptosis after microplastics exposure
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This study found that taurine supplementation protected bovine oocytes from microplastic-induced toxicity by recovering mitochondrial dysfunction during oocyte maturation, suggesting a potential dietary intervention strategy to mitigate reproductive damage from plastic exposure.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.