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61,005 resultsShowing papers similar to Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin
ClearThe Immunotoxic Effects of Environmentally Relevant Micro- and Nanoplastics
Researchers characterized the immunotoxic effects of over 20 types of micro- and nanoplastic particles on macrophages and dendritic cells, finding that physicochemical properties such as size, shape, polymer type, and surface oxidation strongly influence immune cell responses.
Key mechanisms of micro- and nanoplastic (MNP) toxicity across taxonomic groups
This review examines the key ways micro- and nanoplastics cause biological harm across different types of organisms, from bacteria to humans. Researchers identified several common toxicity mechanisms including cell membrane damage, reactive oxygen species generation, DNA damage, and disruption of cellular structures like lysosomes and mitochondria. The study found that toxicity depends heavily on particle size, surface characteristics, and polymer type, and that human cell studies provide especially valuable insights into potential health risks.
Micro and nano-plastics, a threat to human health?
This review examines the threat micro- and nanoplastics pose to human health, discussing how these persistent particles accumulate in organs including lungs, the gastrointestinal system, and blood, and how their chemical composition and size influence toxicity.
Tumorigenic and tumoricidal properties of exosomes in cancers; a forward look
This review explores how tiny cell-released vesicles called exosomes can either promote or fight cancer by transferring signaling molecules between cells. While not directly about microplastics, the research is relevant because nanoplastics are similar in size to exosomes and may interfere with these important cell communication pathways. Understanding how nanoscale particles affect cell signaling could help explain some of the biological effects of nanoplastic exposure.
Micro‐ and Nanoplastics—An Invisible Threat to Human Health
This review describes micro- and nanoplastics as an invisible threat to human health, examining how their small size and chemical complexity make them difficult to detect and assess. The authors call for better analytical tools, standardized methods, and expanded epidemiological research.
Effects of Nanoplastics on Human Health: A Comprehensive Study
This comprehensive review examines the diverse health effects of nanoplastics, drawing on toxicology, environmental science, and epidemiology to document how these particles interact with human biological systems. The authors conclude that nanoplastics represent a growing public health concern requiring further investigation.
The quest for nanoparticle-powered vaccines in cancer immunotherapy
This review explores how nanoparticles are being developed as cancer vaccine delivery systems to train the immune system to fight tumors more effectively. While focused on cancer immunotherapy rather than microplastics, the research highlights that understanding how nanoparticles interact with the immune system is crucial -- the same principles apply to understanding how nanoplastics may affect immune responses in the body.
Microplásticos y nanoplásticos: mecanismos de bioacumulación y toxicidad
This systematic review summarizes current scientific evidence on how micro- and nanoplastics interact with living systems. It found that these tiny particles can accumulate in biological tissues and trigger toxic responses, underscoring growing concerns about their potential effects on human health.
Potential Health Risks of Micro-Nanoplastics and Persistent Organic Pollutants: A Review of Exposure Pathways and Toxic Effects
This review examines how micro- and nanoplastics can enhance the bioavailability of persistent organic pollutants through a Trojan horse effect, leading to combined inflammatory, cellular, and metabolic toxic effects that threaten human health beyond what either contaminant causes alone.
Unveiling the toxicity of micro-nanoplastics: A systematic exploration of understanding environmental and health implications
This review summarizes what is known about the toxicity of micro- and nanoplastics, noting they can cross critical barriers in the body including the blood-brain barrier. Studies in lab animals show these particles can cause DNA damage, oxidative stress, and cell death, with potential effects on the brain, heart, lungs, and skin, underscoring the need for more real-world human studies.
Nanoplastics in the Environment: Sources, Fate, Toxicity, Challenges and Mitigation Strategies
This review covers the formation, environmental fate, and health risks of nanoplastics, emphasizing their capacity to penetrate biological barriers and cause oxidative stress, inflammation, DNA damage, and endocrine disruption, alongside current strategies for mitigation.
Nanoplastic Toxicity: Insights and Challenges from Experimental Model Systems
This review summarizes what researchers have learned about nanoplastic toxicity from studies in cell cultures, aquatic organisms, and terrestrial animals. Evidence indicates that nanoplastics can be internalized by cells through various mechanisms and their toxicity depends on factors like particle size, surface modifications, and concentration. The study identifies key knowledge gaps and recommends more systematic research to better understand the health risks these particles may pose to humans.
A critical viewpoint on current issues, limitations, and future research needs on micro- and nanoplastic studies: From the detection to the toxicological assessment.
This critical review examines the current methods for detecting and characterizing micro- and nanoplastics in various environmental samples, as well as reported toxic effects from in vivo and in vitro studies. The authors found that while substantial effort has been made to understand microplastic behavior, the scientific community is still far from a complete understanding of how these particles behave in biological systems. The review calls for improved standardized protocols and more studies focused on uptake kinetics, accumulation, and biodistribution.
Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance
This review explores how nanotechnology is being used to overcome drug resistance in cancer treatment, using materials like carbon nanotubes, dendrimers, and liposomes to deliver drugs more precisely to tumors. While not directly about microplastics, the nanomaterial strategies discussed share relevance with understanding how nano-sized plastic particles interact with human cells and tissues.
Micro- and nanoplastic toxicity: A review on size, type, source, and test-organism implications
This comprehensive review analyzed 615 studies on the toxicity of micro- and nanoplastics across different polymer types, sizes, and organisms. A major finding is that over 90% of nanoplastic research uses only polystyrene, leaving huge gaps in our understanding of other common plastics at the nanoscale. The review highlights that smaller particles are generally more toxic and that more research is urgently needed on the nanoplastics people are most likely to encounter in everyday life.
Micro- and nanoplastics: origin, sources of intake and impact on human health (literature review)
This literature review synthesizes mechanisms by which micro- and nanoplastics interact with living organisms, examining their physicochemical properties, routes of human exposure, and documented health effects across multiple organ systems.
Recent advances in toxicological research of nanoplastics in the environment: A review
Researchers systematically reviewed nanoplastic toxicology, finding that surface charge and particle size are the dominant determinants of harm — positively charged and smaller particles penetrate cell membranes more readily — and that adsorbed contaminants released inside organisms often pose greater toxicological risks than the nanoplastic particles themselves.
Health impacts of micro- and nanoplastics: key influencing factors, limitations, and future perspectives
This review systematically analyzed how the physicochemical properties of micro- and nanoplastics — including size, shape, surface charge, and polymer type — determine their toxicological impacts across biological systems. The authors argue that property-based frameworks are essential for predicting MNP health risks and designing relevant research.
Combined toxicity of micro/nanoplastics loaded with environmental pollutants to organisms and cells: Role, effects, and mechanism
This review of 162 articles found that micro/nanoplastics act as vectors transporting heavy metals, persistent organic pollutants, drugs, bacteria, and viruses into organisms, with combined exposure often increasing toxicity beyond individual pollutant effects. Nanoplastics' 'Trojan horse' effect specifically increased the bioaccessibility of environmental pollutants, elevating carcinogenic risk to humans.
Physiological induction and reversal of focus formation and tumorigenicity in NIH 3T3 cells
This paper examines the environmental prevalence of micro- and nanoplastics, with special focus on nanoplastics that are small enough to cross biological barriers. The authors highlight that a fundamental knowledge gap remains because current analytical methods cannot reliably detect or quantify nanoplastics.
Microplastics and nanoplastics: Exposure and toxicological effects require important analysis considerations
This review highlights that while microplastics and nanoplastics have been found in human tissues and linked to several diseases, the actual toxic effects are still unclear because researchers use very different methods to study them. The authors call for standardized testing approaches so that results can be compared reliably, which is critical for determining what levels of exposure actually pose a risk to human health.
Micro/nanoplastics in aquatic ecosystems: Analytical challenges, ecological impacts, and mitigation strategies
This review provides a comprehensive assessment of micro- and nanoplastic pollution in aquatic ecosystems, covering detection methods, toxic effects across the food chain, and emerging cleanup strategies. Researchers highlight the limitations of current analytical techniques and the challenges of accurately measuring these tiny particles in water and living organisms. The study identifies key research priorities needed to better understand and mitigate the growing threat of plastic particle pollution in waterways.
Microplastics toxicity, detection, and removal from water/wastewater
This review summarizes the current state of knowledge on microplastic toxicity and methods for detecting and removing them from water and wastewater. It covers the health risks posed by microplastics, including their ability to carry harmful chemicals and pathogens, as well as the strengths and weaknesses of various removal technologies. The authors highlight that while some treatment methods can remove most microplastics, no single approach is fully effective, and better solutions are needed to protect drinking water supplies.
Micro (nano) plastics in wastewater: A critical review on toxicity risk assessment, behaviour, environmental impact and challenges
Researchers reviewed the sources, detection methods, toxicity, environmental fate, and wastewater treatment options for micro- and nanoplastics, finding that nanoplastics are especially persistent and toxic due to their large surface area and ability to carry co-pollutants, and identifying key research gaps in quantification, degradation mechanisms, and sensor development.