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61,005 resultsShowing papers similar to Temporal Trend in Accumulation of Microplastics in Decedent Human Lungs
ClearPresence of airborne microplastics in human lung tissue
Researchers examined human lung tissue from autopsies and found microplastic particles and fibers in 13 out of 20 samples. The most common plastics were polyethylene and polypropylene, with particles smaller than 5.5 micrometers. This study provides direct evidence that inhaled microplastics accumulate in human lungs, raising concerns about potential long-term effects on respiratory health.
Microplastics inhalation: evidence in human lung tissue
Microplastic particles were found in human lung tissue samples collected during surgery, confirming that people inhale and retain microplastics in pulmonary tissue, with polypropylene and polyethylene terephthalate among the polymers identified, raising concerns about chronic respiratory and inflammatory effects.
An emerging role of microplastics in the etiology of lung ground glass nodules
Researchers analyzed 100 human lung tissue samples and identified microplastics embedded in the tissue, with a higher detection rate in tumor samples compared to normal tissue. The abundance of microplastics in lung tissue appeared to increase with age, and the particles seemed to be physically embedded in the tissue rather than simply resting on the surface. The study provides direct evidence linking microplastic accumulation in lungs to ground glass nodules, an increasingly common finding on chest scans.
Bioaccumulation of microplastics in decedent human brains
Researchers found microplastics in human brain, liver, and kidney tissue samples, with plastic levels significantly higher in samples from 2024 compared to 2016. The brain contained especially high levels of polyethylene, and brains from people with dementia had even more plastic accumulation. These findings suggest that microplastics are building up in human organs over time, raising urgent questions about potential health effects.
Microplastics in Human Tissues: Sources, Distribution, Toxicological Effects, and Health Implications
Researchers reviewed the growing body of evidence that microplastics accumulate in human tissues — including lung, blood, placenta, breast milk, and heart tissue — where they can trigger inflammation, oxidative stress, and cell death. The review highlights urgent knowledge gaps around how plastic particles move through the body and what their long-term health effects may be.
Detection and Analysis of Microplastics in Human Sputum
Researchers analyzed sputum (mucus from the lungs) from 22 patients with respiratory diseases and found microplastics in every single sample, identifying 21 different plastic types. Polyurethane was the most common type detected, and most particles were smaller than 500 micrometers. This study provides direct evidence that humans are inhaling microplastics, with factors like smoking and medical procedures increasing the amount found in the respiratory tract.
Tissue accumulation of microplastics and potential health risks in human
Researchers analyzed human tissues and found microplastics in every sample tested, with lungs containing the highest concentration at about 14 particles per gram, followed by the small intestine, large intestine, and tonsils. PVC was the most common plastic type found, and women had significantly more microplastic particles than men, raising concerns about long-term health effects.
Deposition of microplastics associated with bioaccumulation of heavy metals in human lungs of smokers: Implications of adsorption and mobilization of metals via microplastics
Researchers compared lung tissue from smokers and non-smokers and found that smokers accumulated more microplastics alongside elevated levels of heavy metals in lung tissue, suggesting that tobacco smoke enhances chelation of heavy metals to airborne microplastics, increasing lung bioaccumulation.
Unveiling the presence of micro and nanoplastics in human biological matrices: A systematic review covering the latest five years from 2020 to 2025
This systematic review covering 2020-2025 confirmed the presence of micro- and nanoplastics in human blood, placenta, lungs, liver, kidneys, and other biological matrices. The findings demonstrate that plastic particles are accumulating in human tissues through ingestion, inhalation, and dermal contact, raising urgent questions about long-term health consequences.
Respiratory Toxicity of Microplastics: Mechanisms, Clinical Outcomes, and Future Threats
This review summarized the respiratory toxicity of airborne microplastics, covering their sources, the routes by which they penetrate deep into lung tissue, and the range of clinical outcomes from chronic inflammation to potential malignancy. The authors warn that inhalation exposure represents an underappreciated and growing public health threat.
The Effect of Nanoplastics and Microplastics on Lung Morphology and Physiology: a Systematic Review
This systematic review examines how inhaled microplastics and nanoplastics affect lung structure and function. The research found that indoor microplastic concentrations are often higher than outdoor levels due to household materials shedding fibers, and that inhaled particles can accumulate in different parts of the lungs. These findings suggest that breathing in plastic particles at home and work could contribute to respiratory health problems over time.
Chronic lung tissue deposition of inhaled polyethylene microplastics may lead to fibrotic lesions
In a mouse study, inhaled polyethylene microplastics accumulated in lung tissue over 90 days of repeated exposure, causing chronic inflammation, immune changes, and early signs of lung scarring (fibrosis). Even at the lowest doses, the microplastics triggered inflammatory cell buildup and thickening of lung walls. These findings suggest that long-term breathing of airborne microplastics could lead to permanent lung damage, which is concerning given rising levels of plastic particles in indoor and outdoor air.
Detection of Microplastics in Human Bronchoalveolar Lavage Fluid: Preliminary Evidence of Respiratory Exposure to Environmental Contaminants
Researchers analyzed bronchoalveolar lavage fluid from eight adult patients undergoing diagnostic bronchoscopy and detected microplastics in the samples using microscopy, providing preliminary direct evidence that airborne microplastics deposit in the human respiratory tract.
Micro- and Nanoplastics and Pulmonary Health: The Current State of Research
This review evaluates the effects of micro- and nanoplastics on the respiratory system, noting that human autopsy studies confirm these particles are retained in lung tissue. Researchers examined how inhaled plastic particles may induce respiratory inflammation, oxidative stress, and other pulmonary effects. The study highlights that while airborne microplastics are a growing concern, our understanding of their short- and long-term impacts on lung health remains limited.
Microplastics, potential threat to patients with lung diseases
This review examines the potential threat that airborne microplastics pose to people with existing lung conditions, noting that these particles have been found in human lung tissue and sputum. Researchers explored possible mechanisms by which inhaled microplastics could worsen lung diseases, including triggering inflammation and oxidative stress. The study highlights significant knowledge gaps and calls for more research into how microplastic inhalation affects respiratory health.
Detection of microplastics in human lung tissue using μFTIR spectroscopy
Researchers analyzed lung tissue from 13 people and found microplastics in 11 of the samples, identifying 12 different plastic types including polypropylene and polyester. The particles were found in all regions of the lungs, with significantly higher concentrations in the lower lung. This is one of the first studies to directly confirm that microplastics from everyday environments can be inhaled and accumulate deep in human lung tissue.
Post-mortem evidence of microplastic bioaccumulation in human organs: insights from advanced imaging and spectroscopic analysis
Researchers examined tissue samples from deceased individuals and found microplastics in the brain, liver, thyroid, kidney, heart, muscle, and lungs, with the thyroid, kidney, and brain showing the highest contamination at up to 40 particles per gram of tissue. Nanoscale plastic particles smaller than 0.02 micrometers were also detected, indicating that the tiniest plastics can cross biological barriers and accumulate deep in human organs.
Presence of microplastics in human’s respiratory system: bronchoalveolar and bronchial lavage fluid
Researchers analyzed bronchial and bronchoalveolar lavage fluid from patients undergoing bronchoscopy and confirmed the presence of microplastics in the human respiratory system. They characterized the types, sizes, and quantities of microplastic particles found at different levels of the airways. The study provides direct evidence that microplastics deposit within human lungs and suggests that respiratory exposure is a meaningful route of human microplastic intake.
Assessing microplastic and nanoplastic contamination in bird lungs: evidence of ecological risks and bioindicator potential
Researchers examined the lungs of 51 bird species and found microplastics in all of them, averaging over 400 particles per gram of lung tissue, with nanoplastics also detected in five species tested. Birds may serve as early warning indicators of airborne plastic pollution, and the widespread contamination of their lungs suggests that humans breathing the same air face similar exposure risks.
Tracing Microplastics in the Human Body: From Detection to Disease Mechanisms
This review traces the detection of microplastics across multiple human tissues — from nasal lavage and bronchoalveolar fluid to blood and lung tissue — and examines the disease mechanisms linking plastic particle accumulation to respiratory, cardiovascular, and other systemic health effects.
Morphological and chemical characterization of nanoplastics in human tissue
Researchers developed methods to visualize and chemically characterize nanoplastics that have accumulated in human tissue samples. They were able to identify plastic particles smaller than one micrometer within tissue using advanced microscopy and spectroscopy techniques. The study provides some of the first direct evidence of nanoscale plastic accumulation in the human body, which is essential for designing future health effects research.
Micro- and Nanoplastic-Induced Respiratory Disease and Dysfunction: A Scoping Review
A systematic scoping review of 68 studies found that inhaled micro- and nanoplastics are detected in human lung tissue and associated with pulmonary inflammation, fibrosis, and impaired lung function, though most evidence comes from occupational settings and in vitro experiments.
Impact of Airborne Microplastics on Induced Sputum of Urban Dwellers: the Role of Environmental and Occupational Factors
Researchers analyzed induced sputum samples from 25 patients with respiratory diseases and found microplastics present in all samples, with concentrations ranging from 6 to 500 particles per 100 mL. Active smokers and workers in occupations with high plastic exposure had significantly higher microplastic concentrations. The study suggests that airborne microplastic inhalation is widespread among urban residents and may be influenced by both lifestyle and occupational factors.
First evidence of microplastics isolated in European citizens’ lower airway
Researchers provided the first evidence of microplastics in the lower airways of living European adults, using bronchoalveolar lavage fluid from 44 patients. Nearly all detected particles were microfibers averaging about 1.7 millimeters in length, with an average concentration of roughly 9 items per 100 milliliters of fluid. The findings confirm that microplastics reach deep into the human respiratory system, though the health implications require further investigation.