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61,005 resultsShowing papers similar to Synergistic Promotion of Triple‐Negative Breast Cancer Tumorigenesis and Metastasis by Oral Polystyrene Nanoplastics Exposure via Alloprevotella ‐Derived Glutamate and Platelet Activation
ClearInteraction of Polystyrene Nanoplastics and Helicobacter pylori Modulates Gastric Cancer Cellular Functions and Metastasis
Researchers investigated the combined effects of polystyrene nanoplastics and H. pylori bacteria on gastric cancer cells. In laboratory experiments, co-exposure reduced cancer cell viability, increased cell death, and enhanced autophagy. However, in animal models the combined exposure showed an antagonistic effect, where H. pylori actually reduced the metastasis-promoting effects of nanoplastics alone, suggesting complex interactions between nanoplastics and bacterial pathogens in the gut environment.
Interaction of Polystyrene Nanoplastics and Helicobacter pylori Modulates Gastric Cancer Cellular Functions and Metastasis
Researchers examined whether polystyrene nanoplastics and Helicobacter pylori bacteria can jointly enter gastric cancer cells and influence cancer progression. The study found that combined exposure to nanoplastics and H. pylori modulated cell proliferation, apoptosis, autophagy, and metastasis in gastric cancer cells, suggesting that nanoplastic contamination may interact with bacterial infections to affect cancer-related cellular processes.
Interaction of Polystyrene Nanoplastics and Helicobacter pylori Modulates Gastric Cancer Cellular Functions and Metastasis
Researchers examined whether polystyrene nanoplastics and Helicobacter pylori bacteria can jointly enter gastric cancer cells and influence cancer progression. The study found that combined exposure to nanoplastics and H. pylori modulated cell proliferation, apoptosis, autophagy, and metastasis in gastric cancer cells, suggesting that nanoplastic contamination may interact with bacterial infections to affect cancer-related cellular processes.
Interaction of Polystyrene Nanoplastics and Helicobacter pylori Modulates Gastric Cancer Cellular Functions and Metastasis
Researchers examined whether polystyrene nanoplastics and Helicobacter pylori bacteria can jointly enter gastric cancer cells and influence cancer progression. The study found that combined exposure to nanoplastics and H. pylori modulated cell proliferation, apoptosis, autophagy, and metastasis in gastric cancer cells, suggesting that nanoplastic contamination may interact with bacterial infections to affect cancer-related cellular processes.
Interaction of Polystyrene Nanoplastics and Helicobacter pylori Modulates Gastric Cancer Cellular Functions and Metastasis
Researchers examined whether polystyrene nanoplastics and Helicobacter pylori bacteria can jointly enter gastric cancer cells and influence cancer progression. The study found that combined exposure to nanoplastics and H. pylori modulated cell proliferation, apoptosis, autophagy, and metastasis in gastric cancer cells, suggesting that nanoplastic contamination may interact with bacterial infections to affect cancer-related cellular processes.
Microplastics: An emerging environmental risk factor for gut microbiota dysbiosis and cancer development?
This review examines how microplastics may disrupt the gut microbiome and immune system in ways that could promote cancer development. Evidence from recent studies suggests microplastics can cause chronic inflammation, alter the balance of gut bacteria, and trigger molecular pathways linked to several cancer types including lung, liver, breast, and colon cancer. While more human research is needed, the review highlights a concerning connection between microplastic exposure, gut health, and cancer risk.
Interactions between polystyrene-derived micro- and nanoplastics and the microbiota: a systematic review of multi-omics mouse studies
Researchers systematically reviewed 15 mouse studies and found that exposure to polystyrene micro- and nanoplastics consistently disrupted gut bacteria — reducing beneficial species like Lactobacillus and increasing harmful ones — while also altering metabolic pathways throughout the body. Nanoplastics caused more severe microbiome disruption than larger microplastics, highlighting a serious health concern for humans.
Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction
Researchers investigated how micro- and nanoplastics disrupt gut barrier function in mice, finding that different surface chemistries caused varying levels of damage. The study suggests that these plastic particles harm the gut by altering the gut microbiome, which then leads to inflammation and weakening of the intestinal barrier that normally keeps harmful substances out of the body.
Polystyrene nanoplastics disrupt the intestinal microenvironment by altering bacteria-host interactions through extracellular vesicle-delivered microRNAs
Researchers found that polystyrene nanoplastics disrupt the gut lining in mice by altering tiny RNA molecules that control the production of protective proteins in the intestinal barrier. The nanoplastics also caused an imbalance in gut bacteria, creating a chain reaction where damaged gut cells release particles that further weaken the intestinal barrier and change the microbiome.
Environmental Pollution and Breast Cancer: The Microplastic Component BPA Regulates the Intratumoral Immune Microenvironment and Increases Lung Metastasis
Bisphenol A (BPA), a chemical found in many plastics, was shown to alter the immune environment within breast tumors and increase lung metastasis in mice. The findings suggest that BPA exposure may worsen cancer outcomes by promoting spread of the disease.
Do Engineered Nanomaterials Affect Immune Responses by Interacting With Gut Microbiota?
This review examined evidence that engineered nanomaterials including nanoplastics can indirectly modulate immune responses by altering gut microbiota composition, finding that while direct immunotoxicity is often mild, microbiome disruption provides an indirect pathway through which nanomaterials may impair host immunity.
Uncovering the nexus of human health hazards of nanoplastics, gut-dysbiosis and antibiotic-resistance
This review provides the first comprehensive synthesis specifically linking nanoplastic exposure to gut dysbiosis and antibiotic resistance gene propagation, finding that nanoplastics suppress beneficial microbes while fostering pathogens and creating conditions that promote horizontal transfer of resistance genes.
The role of gut microbiota in mediating increased toxicity of nano-sized polystyrene compared to micro-sized polystyrene in mice
This mouse study found that nano-sized polystyrene plastics were significantly more toxic than micro-sized ones, causing greater gut inflammation, liver damage, and metabolic disruption. The key difference was driven by how each size affected gut bacteria: nanoplastics caused a more severe shift toward harmful bacteria and away from beneficial ones. The findings suggest that the smallest plastic particles may pose the greatest health risk because they more dramatically disrupt the gut microbiome.
Polystyrene nanoplastics promote colitis-associated cancer by disrupting lipid metabolism and inducing DNA damage
In a mouse study, polystyrene nanoplastics accelerated the development of colon cancer linked to inflammatory bowel disease by disrupting fat metabolism and causing DNA damage in intestinal cells. The nanoplastics also altered gut bacteria and increased intestinal inflammation, suggesting that plastic particle exposure could worsen outcomes for people already at risk for colon cancer.
Microplastics role in cell migration and distribution during cancer cell division
Researchers exposed human colorectal cancer cells to polystyrene micro- and nanoplastics and found the particles persisted inside cells without being eliminated, were passed from parent to daughter cells during division, and significantly increased cell migration -- a key step in cancer spreading. These findings suggest microplastics could act as hidden promoters of tumor progression in the gut, where plastic exposure through food is highest.
Polystyrene micro- and nanoplastics in a colitis mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Researchers exposed colitis mouse models to polystyrene micro- and nanoplastics to test whether MNP exposure worsens inflammatory bowel disease, finding that MNPs altered biodistribution and exacerbated inflammatory responses in animals with pre-existing gut inflammation.
Effects of partial reduction of polystyrene micro-nanoplastics on the immunity, gut microbiota and metabolome of mice
This mouse study examined whether partial gut degradation of polystyrene micro- and nanoplastics affects immune markers, gut microbiota, and metabolome, finding that nanoplastic exposure produced distinct immune and microbial changes compared to microplastic exposure. Notably, different exposure doses shifted the key bacterial species stabilizing gut microbial networks.
Trehalose Acts as a Mediator: Imbalance in Brain Proteostasis Induced by Polystyrene Nanoplastics via Gut Microbiota Dysbiosis during Early Life
Researchers found that polystyrene nanoplastics caused brain damage in young mice by disrupting gut bacteria, which in turn altered levels of a sugar called trehalose that is important for brain protein balance. Fecal transplant experiments confirmed that about 39% of the brain damage was driven indirectly through gut microbiome changes rather than nanoplastics reaching the brain directly. The study highlights the gut-brain connection as a key pathway through which nanoplastics may harm neurological development in early life.
Role of Nanoplastics in Decreasing the Intestinal Microbiome Ratio: A Review of the Scope of Polystyrene
This scoping review of 56 studies found consistent evidence that polystyrene nanoplastics (≤100 nm) disrupt gut homeostasis through a three-stage cascade: ROS generation and oxidative stress, intestinal barrier dysfunction, and gut microbiome dysbiosis, with downstream effects on immunity and multiple organs.
Gut Check: Microbiota and Obesity in Mice Exposed to Polystyrene Microspheres
Researchers found that gut microbiota appeared to play a mediating role in the obesity outcomes observed in mice fed manufactured polystyrene microspheres, suggesting that microplastic-induced alterations to the gut microbiome may be a mechanism linking microplastic exposure to metabolic dysfunction and weight gain.
Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction
Mice were exposed to polyethylene terephthalate nanoparticles, and researchers used histopathology, metabolomics, and metagenomics to track downstream effects. Nanoplastic ingestion caused severe metabolic disruption—including weight loss, organ atrophy, and liver-intestinal dysfunction—by remodeling the bile acid–gut microbiota axis.
Gut microbiota and metabolic health risks from chronic low-dose microplastic exposure with focus on Desulfovibrio spp.
Researchers investigated the effects of long-term, low-dose polystyrene microplastic intake on gut bacteria and metabolism in mice. They found that even low doses significantly altered the gut microbiome, increasing bacteria linked to gastrointestinal inflammation and colorectal cancer risk, while also disrupting lipid and amino acid metabolism. The study suggests that routine microplastic exposure through food and water could quietly shift gut health in ways associated with chronic metabolic conditions.
Detection and quantification of microplastics in various types of human tumor tissues
Researchers detected microplastics in 43% of tumor samples across lung, gastric, colorectal, cervical, and pancreatic cancers, with polystyrene, PVC, and polyethylene being the types found. In pancreatic tumors, microplastic presence was associated with fewer immune cells that fight cancer and more immune cells linked to tumor progression, suggesting microplastics may create conditions that help tumors evade the immune system.
Intergenerational neurotoxicity of polystyrene nanoplastics in offspring mice is mediated by dysfunctional microbe-gut-brain axis
Researchers found that mother mice exposed to polystyrene nanoplastics during pregnancy and nursing passed neurological harm to their offspring, with the babies showing brain inflammation, disrupted dopamine and serotonin signaling, and gut microbiome imbalances — suggesting that nanoplastic exposure before birth can damage the developing brain through the gut-brain connection.