Papers

61,005 results
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Article Tier 2

Effects of Exposure to Cadmium, Microplastics, and Their Mixture on Survival, Growth, Feeding, and Life History of Daphnia magna

Researchers examined how polyethylene microplastics altered cadmium toxicity to Daphnia magna, finding that microplastic co-exposure modified cadmium bioavailability and affected survival, growth, feeding rates, and reproductive outcomes in this ecologically important species.

2023 Environmental Toxicology and Chemistry 9 citations
Article Tier 2

Antagonistic effects of copper and microplastics in single and binary mixtures on development and reproduction in the freshwater cladoceran Daphnia carinata

Combined exposure of the freshwater cladoceran Daphnia carinata to polyethylene microplastics and copper showed antagonistic effects on survival and reproduction, with microplastics reducing the bioavailability of copper through adsorption, resulting in lower combined toxicity than copper alone at some concentrations.

2021 Environmental Technology & Innovation 17 citations
Article Tier 2

Combined Effect of Polystyrene Particles and Copper Ions on the Vital Parameters of Daphnia Magna in a Series of Generations

Researchers studied the combined effects of polystyrene microplastics and copper ions on Daphnia magna over four generations using both short-term and continuous exposure designs. Toxicity was greater under combined exposure and increased across generations, suggesting cumulative intergenerational harm from mixed pollutant stress.

2025 Transactions of Papanin Institute for Biology of Inland Waters RAS
Article Tier 2

Adverse Effects of Co-Exposure to Cd and Microplastic in Tigriopus japonicus

Researchers exposed the marine copepod Tigriopus japonicus to combined cadmium and polystyrene microplastic exposure using a full concentration-response design. Co-exposure increased toxicity compared to either contaminant alone, with effects on survival, reproduction, and development, indicating synergistic or additive interactions between cadmium and microplastics.

2022 International Journal of Environmental Research and Public Health 16 citations
Article Tier 2

Exposure scenarios modulate the combined toxicity of nanoplastics and Cd to Daphnia magna

Researchers evaluated how different exposure scenarios (single, pre-exposure, and co-exposure) affect the combined toxicity of nanoplastics and cadmium to the water flea Daphnia magna. The study found that environmentally relevant concentrations of nanoplastics initially stimulated reproduction, but the timing and sequence of exposure significantly influenced bioaccumulation, intestinal damage, and gut microbiota disruption.

2026 Environmental Pollution
Article Tier 2

Toxicological effects of microplastics and heavy metals on the Daphnia magna

Researchers studied how polystyrene microplastics of two sizes adsorb heavy metals and how their combined presence affects the water flea Daphnia magna. They found that smaller microplastics had higher adsorption capacity for metals, and the combined toxicity shifted from antagonistic to additive effects as microplastic concentrations increased. The study reveals that smaller microplastics pose a greater toxicological risk when combined with heavy metals in aquatic environments.

2020 The Science of The Total Environment 184 citations
Article Tier 2

Additive effects of microplastics on accumulation and toxicity of cadmium in male zebrafish

Researchers exposed adult zebrafish to polyethylene microplastics and cadmium, both individually and in combination, for 21 days. They found that microplastics and cadmium together produced additive toxic effects, increasing cadmium accumulation in fish tissues, altering behavior, and causing more severe organ damage. The study suggests that microplastics in contaminated waterways may worsen the harmful effects of heavy metals on aquatic life.

2023 Chemosphere 25 citations
Article Tier 2

Effects of microplastics and their adsorption of cadmium as vectors on the cladoceran Moina monogolica Daday: Implications for plastic-ingesting organisms

Scientists examined how polyethylene microplastics adsorb cadmium and then tested the combined effects on the water flea Moina monogolica over 21 days, finding that cadmium-laden microplastics caused greater reproductive and developmental harm than either stressor alone.

2020 Journal of Hazardous Materials 92 citations
Article Tier 2

Single and combined acute and subchronic toxic effects of microplastics and copper in zebrafish (Danio rerio) early life stages

Researchers exposed zebrafish embryos and larvae to microplastics, copper, and their combinations to assess individual and combined toxic effects. They found that microplastics alone caused limited harm, but when combined with copper, the mixture produced altered biochemical responses and changes in gene expression. The study suggests that microplastics can modify the toxicity of heavy metals in aquatic organisms during early development.

2021 Chemosphere 96 citations
Article Tier 2

Toxicological interactions induced by chronic exposure to gold nanoparticles and microplastics mixtures in Daphnia magna

This study examined the combined toxicological effects of gold nanoparticles and microplastics through chronic exposure, finding interactive effects that differed from either contaminant alone, emphasizing the importance of studying multiple stressors together.

2018 The Science of The Total Environment 154 citations
Article Tier 2

Short- and long-term single and combined effects of microplastics and chromium on the freshwater water flea Daphnia magna

Researchers investigated the individual and combined effects of microplastics and chromium on the water flea Daphnia magna in both short- and long-term experiments. They found that microplastics interacted with chromium, reducing its concentration in water, and that co-exposure caused acute toxicity but lacked the chronic effects seen with chromium alone. The study suggests that microplastics may alter the bioavailability and toxicity of metal pollutants in freshwater environments.

2022 Aquatic Toxicology 44 citations
Article Tier 2

Multi-Biomarker Responses of Asian Clam Corbicula fluminea (Bivalvia, Corbiculidea) to Cadmium and Microplastics Pollutants

Researchers exposed Asian clams to cadmium, microplastics, and their mixtures, then measured a battery of biomarkers including oxidative stress, energy metabolism, and neurotoxicity indicators. They found that the combined exposure to cadmium and microplastics produced interactive effects that differed from exposure to either contaminant alone. The study demonstrates that microplastics can modify the toxicity of heavy metals in freshwater bivalves, highlighting the importance of studying pollutant mixtures rather than individual contaminants.

2021 Water 61 citations
Article Tier 2

Action of Surfactants in Driving Ecotoxicity of Microplastic-Nano Metal Oxides Mixtures: A Case Study on Daphnia magna under Different Nutritional Conditions

This study tested how surfactants (found in detergents and cleaning products) interact with microplastics and metal oxide nanoparticles to affect the toxicity of these combined pollutants on water fleas (Daphnia magna). Surfactants increased the toxicity of microplastic-nanoparticle mixtures, and the effect varied with the age and nutritional status of the test organisms. This highlights how the complex real-world mixture of pollutants in waterways can be more harmful than any single contaminant alone.

2021 IntechOpen eBooks 2 citations
Article Tier 2

Evaluation of single and combined effects of cadmium and micro-plastic particles on biochemical and immunological parameters of common carp (Cyprinus carpio)

Researchers investigated the individual and combined toxicity of cadmium and polystyrene microplastics on common carp over 30 days. They found that co-exposure to both pollutants produced more severe effects on liver enzymes, immune function, and biochemical markers than either pollutant alone. The study suggests that microplastics can enhance the toxicity of heavy metals in aquatic organisms, raising concerns about the combined impact of these co-occurring contaminants.

2019 Chemosphere 323 citations
Article Tier 2

Combined effects of polystyrene microplastics and copper on the growth and nutritional profile of Raphidocelis subcapitata

Researchers investigated the combined effects of polystyrene microplastics and copper on the growth and nutritional profile of the freshwater green alga Raphidocelis subcapitata, examining whether co-exposure to these two contaminants produces interactive toxicity effects beyond individual exposures.

2022 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Combined toxic effects of cadmium and environmental microplastics in Aphanius fasciatus (Pisces, Cyprinodontidae)

Researchers found that combined exposure to cadmium and microplastics in killifish caused oxidative stress and spinal deformities, though the two pollutants did not show clear synergistic interaction, likely because microplastics reduced cadmium bioavailability.

2023 Marine Environmental Research 13 citations
Article Tier 2

The Acute Toxic Impact of Iron (Fe) and Lead (Pb) Individually and Their Mixture on Daphnia magna (Straus, 1820)

Researchers tested the acute toxicity of iron and lead, both individually and as a mixture, on the water flea Daphnia magna. They found that iron was more toxic than lead, and when combined, the metals exhibited a synergistic effect that increased overall toxicity. The study provides baseline ecotoxicological data relevant to understanding how heavy metal mixtures in contaminated water bodies may affect aquatic invertebrate populations.

2024 Egyptian Journal of Aquatic Biology and Fisheries 2 citations
Article Tier 2

Developmental toxicity of co-exposure of heavy metal and polystyrene microplastics in Xenopus laevis embryo

Researchers exposed Xenopus laevis frog embryos simultaneously to cadmium, copper, lead, and polystyrene microbeads, finding that co-exposure produced more complex effects than any single contaminant and that interactions included antagonistic as well as additive outcomes.

2025 The Science of The Total Environment
Article Tier 2

Mixture Toxicity of Nickel and Microplastics with Different Functional Groups on Daphnia magna

Researchers investigated the combined toxicity of nickel and two types of polystyrene microplastics with different surface chemistries on Daphnia magna. They found that the presence of microplastics altered the toxicity of nickel, with surface functional groups playing an important role in determining the severity of combined effects. The study demonstrates that microplastics can modify the bioavailability and toxicity of heavy metals in freshwater environments.

2017 Environmental Science & Technology 282 citations
Article Tier 2

Single and Combined Effects of Microplastics and Cadmium on the Cadmium Accumulation and Biochemical and Immunity of Channa argus

Researchers investigated the single and combined effects of microplastics and cadmium on juvenile snakehead fish, finding that co-exposure caused greater tissue damage, oxidative stress, and immune disruption than either pollutant alone.

2021 Biological Trace Element Research 38 citations
Article Tier 2

Effects of different routes of exposure to metals on bioaccumulation and population growth of the cyclopoid copepod Paracyclopina nana

Researchers exposed the marine copepod Paracyclopina nana to cadmium, copper, and nickel individually and in mixtures, finding that metals compete with each other for bioaccumulation and that copepod populations pre-adapted to elevated copper showed greater ability to depurate toxic metals and recover population growth.

2020 Chemosphere 12 citations
Article Tier 2

Comparison of the combined toxicity of polystyrene microplastics and different concentrations of cadmium in zebrafish

Researchers studied the combined toxic effects of polystyrene microplastics and cadmium at different concentrations in zebrafish over a 10-day exposure period. The study found that microplastics could either amplify or reduce cadmium toxicity depending on the metal concentration, affecting survival, growth, and antioxidant responses in complex ways.

2022 Aquatic Toxicology 58 citations
Article Tier 2

The single and combined effects of mercury and polystyrene plastic beads on antioxidant-related systems in the brackish water flea: toxicological interaction depending on mercury species and plastic bead size.

Exposure of small crustaceans to mixtures of mercury and polystyrene plastic beads showed complex toxicological interactions — the effects depended on both the size of the plastic beads and the chemical form of mercury. The findings highlight that the real-world health risks of plastic pollution cannot be understood in isolation from the other chemicals that co-occur with plastics in aquatic environments.

2022 Aquatic toxicology (Amsterdam, Netherlands)
Article Tier 2

Impacts of microplastics and pesticides on Daphnia

Researchers investigated the combined and individual impacts of microplastics and pesticides on Daphnia magna, a model crustacean widely used in freshwater ecotoxicology, to assess how these co-occurring pollutants affect aquatic ecosystem health. The study examined survival, reproduction, and physiological responses in D. magna exposed to varying concentrations of both stressors under controlled conditions.

2025 Fisher Digital Publications (St. John Fisher College)