We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
61,005 resultsShowing papers similar to Nanoplastics impact the zebrafish (Danio rerio) transcriptome: Associated developmental and neurobehavioral consequences
ClearTranscriptional effects of polyethylene microplastics ingestion in developing zebrafish (Danio rerio)
Researchers exposed developing zebrafish to polyethylene microplastics and used transcriptomic analysis to identify changes in gene expression related to immune function, lipid metabolism, and oxidative stress. The study suggests that even at relatively low concentrations, ingested microplastics can alter key biological pathways during early fish development.
Molecular effects of polystyrene nanoplastics toxicity in zebrafish embryos (Danio rerio)
Researchers exposed zebrafish embryos to polystyrene nanoplastics at various concentrations and measured gene expression changes related to stress, inflammation, and DNA repair. They found dose-dependent activation of oxidative stress and apoptotic pathways at the highest concentration, along with inhibition of the neurotransmitter-related gene acetylcholinesterase and DNA repair genes. The study suggests that nanoplastic exposure at the molecular level may compromise cellular defense mechanisms and neurological function in developing fish.
Adverse adult-onset and multigenerational effects in zebrafish (Danio rerio) developmentally exposed to polystyrene nanoplastics
Researchers raised zebrafish exposed to nanoplastics during early development through to adulthood and found lasting reproductive impairment, heritable hyperactivity in offspring, and molecular changes in male reproductive and brain tissue linked to neurodegenerative disease pathways and endocrine disruption, demonstrating that brief developmental nanoplastic exposure can cause multigenerational harm.
Nanoplastics Cause Neurobehavioral Impairments, Reproductive and Oxidative Damages, and Biomarker Responses in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure
Researchers exposed adult zebrafish to polystyrene nanoplastics and found that the particles accumulated in the brain, liver, intestine, and gonads, causing significant behavioral and physiological changes. The fish showed disrupted energy metabolism, oxidative stress, and altered locomotion, aggression, and predator avoidance behaviors. The findings raise concerns about the widespread health risks of nanoplastic exposure, as these particles are small enough to cross biological membranes.
Effects of Microplastics and Nanoplastics on Neurodevelopment and Neurodegeneration in Zebrafish
This review covers how micro- and nanoplastic (MNP) exposure affects neurodevelopment and neurodegeneration in zebrafish, summarising evidence on impaired neurodevelopment, behavioural changes, and markers of neurodegeneration from studies using various polymer types and exposure routes. It frames zebrafish as a key model for understanding MNP neurotoxicity.
Bioaccumulation of various nanoplastic particles in larval zebrafish (Danio rerio)
Researchers exposed larval zebrafish (Danio rerio) to 40-60 nm and 100 nm polystyrene nanoplastic particles using standard fish embryo toxicity and general behavioral toxicity assays from 6-120 hours post-fertilization, combining toxicity endpoints with fluorescence microscopy to confirm particle uptake and excretion. The study demonstrated nanoplastic accumulation within zebrafish larvae at tested concentrations, providing mechanistic insights into aquatic organism exposure dynamics for nanoplastics.
Nanoplastics induce neuroexcitatory symptoms in zebrafish (Danio rerio) larvae through a manner contrary to Parkinsonian's way in proteomics
Researchers found that polystyrene nanoplastics caused hyperactive behavior in zebrafish larvae by disrupting dopamine signaling and inhibiting a key brain enzyme. Interestingly, the mechanism was the opposite of what is seen in Parkinson's disease, with nanoplastics increasing rather than decreasing dopamine activity. The study provides evidence that nanoplastics can cross the blood-brain barrier and interfere with nervous system function in developing organisms.
Impacts of Environmental Concentrations of Nanoplastics on Zebrafish Neurobehavior and Reproductive Toxicity
Researchers exposed zebrafish to environmentally realistic levels of polystyrene nanoplastics and found they caused both brain and reproductive damage. The nanoplastics disrupted neurotransmitter signaling and impaired the hormonal pathway connecting the brain to reproductive organs, with different effects in males and females. These findings suggest that even low-level nanoplastic exposure could affect both brain function and fertility in aquatic life that humans may consume.
Evaluation of phenotypic and behavioral toxicity of micro- and nano-plastic polystyrene particles in larval zebrafish (Danio rerio)
Researchers exposed zebrafish embryos to polystyrene particles ranging from 50 nanometers to 10 micrometers and found that nearly all sizes caused physical abnormalities and changes in swimming behavior. Smaller particles were taken up more readily and distributed to organs including the brain and gut. These findings are relevant to human health because zebrafish share many biological pathways with humans, and the results suggest that both micro- and nano-sized plastics can cause developmental harm.
Pathway analysis of systemic transcriptome responses to injected polystyrene particles in zebrafish larvae
Researchers injected fluorescent polystyrene particles into zebrafish embryos at different developmental stages and tracked their distribution and biological effects using imaging and transcriptomics. Particles injected into the yolk of older embryos spread through the bloodstream and accumulated near the heart, triggering strong immune and inflammatory gene responses. The study reveals that even localized microplastic exposure can produce system-wide biological effects in developing organisms.
Polystyrene nanoplastics induce developmental impairments and vasotoxicity in zebrafish (Danio rerio)
Zebrafish exposed to polystyrene nanoplastics at environmentally realistic concentrations showed developmental problems including heart defects, brain abnormalities, blood vessel damage, and reduced swimming ability. The nanoplastics accumulated on the fish's body and triggered cell damage and oxidative stress even at very low doses. Since zebrafish are commonly used to model human developmental processes, these findings raise concerns about what nanoplastic exposure could mean for early human development.
Exposure to microplastics decreases swimming competence in larval zebrafish (Danio rerio)
Researchers exposed zebrafish embryos and larvae to polystyrene microplastics and found that the particles adhered to egg surfaces before being ingested into the stomach and intestines after hatching. At higher concentrations, exposed larvae showed significantly reduced swimming distance and speed, along with upregulated genes related to inflammation and oxidative stress. The study suggests that microplastic exposure can impair swimming ability in larval fish, which could have broader ecological consequences for population fitness.
Plastic nanoparticles cause mild inflammation, disrupt metabolic pathways, change the gut microbiota and affect reproduction in zebrafish: A full generation multi-omics study.
Exposure of zebrafish to polystyrene nanoparticles throughout their entire first generation caused mild inflammation, disrupted metabolic pathways, altered gut microbiota, and impaired reproduction — even at environmentally relevant concentrations. This comprehensive multigenerational study demonstrates that nanoplastic exposure can have lasting biological effects across multiple body systems in fish.
Transcriptome sequencing and metabolite analysis reveal the toxic effects of nanoplastics on tilapia after exposure to polystyrene
Researchers exposed larval tilapia to polystyrene nanoplastics and then analyzed changes in gene expression and metabolic profiles after a recovery period. They found that nanoplastic exposure disrupted immune-related pathways, energy metabolism, and lipid processing in the fish, with some effects persisting even after exposure ended. The study suggests that nanoplastics can cause lasting metabolic and immune disruptions in freshwater fish.
Polystyrene nanoplastics induced size-dependent developmental and neurobehavioral toxicities in embryonic and juvenile zebrafish
Researchers exposed zebrafish embryos and juveniles to polystyrene nanoplastics of three different sizes and found that all sizes crossed into the brain, eyes, and other organs. Smaller particles tended to cause different types of damage than larger ones, including changes in brain development and behavior. This size-dependent toxicity is relevant to human health because we are exposed to a wide range of nanoplastic sizes through food and water.
From particle size to brain function: a zebrafish-based review of micro/nanoplastic-induced neurobehavioral toxicity and mechanistic pathways
This review uses zebrafish as a model to examine how micro- and nanoplastics cause neurobehavioral toxicity, linking particle size to brain function disruption. Researchers summarize evidence that these plastic particles impair fish behavior and cause molecular-level damage in the nervous system. The findings highlight the growing concern that micro- and nanoplastics are emerging neurotoxicants in aquatic environments.
Developmental exposure to polystyrene nanoplastics induces persistent neurobehavioral changes and alters later-life susceptibility to hexabromocyclododecane in zebrafish
Researchers exposed zebrafish embryos to polystyrene nanoplastics during early development and tracked behavioral effects into adulthood. The study found that early-life nanoplastic exposure caused persistent reductions in locomotor activity and altered how adult fish responded to a common flame retardant chemical. Evidence indicates that epigenetic changes, including altered DNA methylation and gene expression patterns, may underlie these long-lasting behavioral effects.
Neurotoxicity of polystyrene nanoplastics with different particle sizes at environment-related concentrations on early zebrafish embryos
Researchers exposed zebrafish embryos to polystyrene nanoplastics of different sizes at concentrations found in the environment and observed significant brain damage. The nanoplastics caused loss of neurons, shortened nerve fibers, and disrupted brain signaling systems that control behavior. Smaller nanoplastics caused the most severe damage because they could pass through protective barriers more easily, suggesting that the tiniest plastic particles pose the greatest risk to brain development.
Polystyrene microplastics and nanoplastics induce neurotoxicity in zebrafish via oxidative stress and neurotransmitter disruption
Researchers exposed zebrafish embryos to polystyrene micro- and nanoplastics and found that both particle sizes caused neurodevelopmental toxicity, with nanoplastics being more potent. The plastic particles induced oxidative stress in the brain and disrupted neurotransmitter levels critical for normal neural development. The study suggests that microplastic and nanoplastic contamination in aquatic environments may pose significant risks to the neurological development of fish.
Nanoplastic exposure damages neural plasticity, cognitive abilities, and ecological adaptability of marine medaka Oryzias melastigma
Researchers exposed marine medaka fish to 50-nanometer polystyrene nanoplastics and found reduced cognitive abilities, with fish making faster but less accurate decisions in learning tasks. Exposed fish also showed altered social behavior, maintaining closer distances to each other while increasing reliance on shelters, indicating reduced ecological adaptability. Transcriptomic analysis revealed changes in genes involved in cell adhesion, signal transduction, and oxidative stress pathways.
Early-life microplastic exposure elicits ADHD-like behaviors by disrupting dopaminergic neurodevelopment in zebrafish
Zebrafish larvae exposed to polystyrene microplastics during early development showed ADHD-like hyperactivity and impulsivity, along with a ~30% increase in dopaminergic neurons. Transcriptomic analysis confirmed dysregulation of dopamine-associated signaling pathways, suggesting early-life microplastic exposure may impair neurodevelopment.
Polystyrene nanoplastics enhance the toxicological effects of DDE in zebrafish (Danio rerio) larvae
Researchers found that polystyrene nanoplastics enhanced the toxicity of the pesticide metabolite DDE in zebrafish larvae, with co-exposure causing greater developmental abnormalities and oxidative stress than either pollutant alone.
Evaluation of phenotypic and behavioral toxicity of micro- and nano-plastic polystyrene particles in larval zebrafish ( Danio rerio )
Researchers exposed larval zebrafish (Danio rerio) to six sizes (0.05–10.2 µm) and multiple concentrations of polystyrene micro/nanoplastics and assessed toxicity using embryo and behavioral assays. Smaller particles and higher concentrations caused greater phenotypic and behavioral toxicity, with particle uptake and organ distribution confirmed, establishing size as a key determinant of polystyrene MP toxicity in a vertebrate developmental model.
Polystyrene Nanoplastic Exposure Adversely Affects Survivability of Zebrafish Larvae
Researchers found that polystyrene nanoplastic exposure significantly reduces survival rates of zebrafish larvae in a dose-dependent manner, documenting behavioral abnormalities and developmental defects that highlight the toxicity of nanoscale plastic particles to early vertebrate life.