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Papers
61,005 resultsShowing papers similar to The exposome paradigm to predict environmental health in terms of systemic homeostasis and resource balance based on NMR data science
ClearAnalytical challenges in human exposome analysis with focus on environmental analysis combined with metabolomics
This review examined the analytical challenges of characterizing the human chemical exposome, covering sampling, sample preparation, and compound identification hurdles that currently limit our ability to link specific environmental chemical exposures to chronic disease outcomes.
Polybiome Systems Medicine: Conceptual Architecture, Methodological Foundations, and Translational Applications — Volume I: Vision and Foundational Methodology
This foundational document presents the Polybiome Systems Medicine framework, proposing that the human organism is a co-constructed biological consortium shaped by host genomics, multi-kingdom microbiomes, environmental exposures, and immune networks. The framework incorporates environmental factors including microplastics and endocrine disruptors as modulators of human health. The authors outline a five-layer architecture designed to integrate diverse biological data for a more holistic approach to medicine.
Exposomics as a discovery engine for emerging contaminants and hidden biological risks
This review examined how exposomics—the science of comprehensively characterizing all chemical exposures an individual encounters—has matured into a practical discovery tool for identifying emerging contaminants and hidden health risks. The authors found that high-resolution mass spectrometry combined with multi-omics and wearable sensors can uncover chemical exposures missed by conventional targeted monitoring.
Environmental Chemicals: Integrative Approach to Human Biomonitoring and Health Effects
This review presents an integrative framework for human biomonitoring of environmental chemicals — including microplastics, heavy metals, and endocrine disruptors — linking population-level exposure data with health outcomes to inform policy decisions on chemical risk management.
Exposomics as a discovery engine: a systematic scoping review of emerging environmental contaminants and novel biological effects
This scoping review mapped how exposomics tools—including high-resolution mass spectrometry, multi-omics integration, and wearable sensors—have been applied over the past decade to discover novel environmental contaminant exposures and their health effects. It found emerging contaminants like microplastics and PFAS increasingly captured by non-targeted approaches.
Polybiome Systems Medicine: Conceptual Architecture, Methodological Foundations, and Translational Applications — Volume I: Vision and Foundational Methodology
This white paper introduces a theoretical framework called Polybiome Systems Medicine, which views the human body as a complex biological consortium shaped by genomic, microbial, environmental, and immune interactions. The framework includes environmental exposomes such as microplastics and endocrine disruptors as key factors influencing human health. The authors propose a five-layer systems architecture for integrating these diverse biological and environmental inputs into a unified medical model.
Symbiotoxicity: The Ability of Environmental Stressors to Damage Healthy Microbiome Structure and Interactions with the Host
This review proposes the concept of symbiotoxicity to describe how environmental stressors including microplastics, chemicals, and pathogens can disrupt healthy host-microbiome interactions, arguing that damage to the microbiome should be considered a distinct endpoint in ecological risk assessment.
Exploring the Exposome Spectrum: Unveiling Endogenous and Exogenous Factors in Non-Communicable Chronic Diseases
This review explores the concept of the exposome -- the total of all environmental exposures a person encounters throughout their lifetime, including chemical pollutants, microplastics, air pollution, and stress. It highlights how these combined exposures interact to drive chronic diseases like cancer, heart disease, and diabetes, emphasizing that microplastics are one piece of a larger puzzle of environmental health threats.
Aquatic ecosystem indices, linking ecosystem health to human health risks
Researchers reviewed indicators used to assess aquatic ecosystem health and found that most existing tools don't adequately capture the risks that degraded water ecosystems pose to human health and well-being. They propose a new set of combined indicators — covering chemical contaminants, pathogens, and biological markers — to better link ecosystem health monitoring to human health outcomes.
Effects of Environmental Exposure on Host and Microbial Metabolism
This collection of studies investigates how environmental exposures, including microplastics, PFAS, and other emerging pollutants, disrupt the gut microbiota and alter host metabolism. The research covers a wide spectrum of contaminants and examines how they affect the trillions of microorganisms in the gastrointestinal tract that play essential roles in human health. The findings suggest that environmental pollutants can drive metabolic changes by disrupting the balance between gut microbes and their human hosts.
Multi stress system: Microplastics in freshwater and their effects on host microbiota
This study examined how combined exposure to microplastics and organic chemical pollutants affects freshwater organisms through a multi-stress approach, focusing on gut microbiome changes as an indicator. Microplastic exposure in combination with other pollutants altered microbiome composition more than either stressor alone, with potential consequences for host fitness and disease resistance.
Improving the assessment of ecosystem and wildlife health: microbiome as an early indicator
Researchers reviewed evidence that the microbiome — the community of microorganisms living in environments and within animals — can serve as an early warning system for ecosystem disturbance, rapidly reflecting the impact of human activities before other signs of harm are visible.
Leveraging integrative toxicogenomic approach towards development of stressor-centric adverse outcome pathway networks for plastic additives
Researchers applied integrative toxicogenomics to develop adverse outcome pathway networks for plastic additives that leach into the environment during plastic degradation. The study suggests that this approach can help systematically assess the health risks of chemical additives released from plastics across atmospheric, terrestrial, and aquatic ecosystems.
Expanding adverse outcome pathways towards one health models for nanosafety
This study proposes expanding adverse outcome pathway frameworks to incorporate One Health models for nanomaterial safety assessment. The research suggests that connecting chemical safety assessment, epidemiology, and ecology through a holistic multiscale approach could better evaluate the risks of nano-enabled products for both humans and the environment.
Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms
This review described how environmental metabolomics — measuring small-molecule profiles in model organisms — can be used to assess the toxicity of environmental contaminants including microplastics, heavy metals, and pesticides, and highlighted key organisms, methods, and data analysis approaches.
Impact of Cumulative Environmental and Dietary Xenobiotics on Human Microbiota: Risk Assessment for One Health
This review examines cumulative exposure to environmental and dietary xenobiotics including microplastics, pesticides, and food additives, assessing their combined impact on the human gut microbiome within a One Health risk framework.
Development of Cohort-Based Prediction Model for Human Health in Relation to Ecological Aspects
Researchers developed a cohort-based prediction model linking ecological factors including environmental conditions, socioeconomic constraints, and demographic parameters to human health outcomes. The model was designed to serve as a reference tool for ecosystem modeling and to assess health vulnerability to infectious diseases and environmental stressors across populations.
Multi-omics approaches for remediation of bisphenol A: Toxicity, risk analysis, road blocks and research perspectives
This review used multi-omics approaches to assess the toxicity of bisphenol A and its pathways for environmental remediation, integrating genomics, transcriptomics, and metabolomics data. The authors identified microbial and biochemical strategies with potential for BPA removal from contaminated environments while clarifying risk to human and ecosystem health.
Metabolomics Approach in Environmental Studies: Methodologies, Application and Challenges
This review examines how metabolomics, the study of small molecules in biological systems, is being applied to environmental research to understand how chemical pollutants including microplastics affect organism metabolism. The study highlights metabolomics as a valuable tool for assessing the biological effects of environmental exposures at the molecular level, helping researchers identify biomarkers of pollutant exposure in both wildlife and humans.
Chemical Mixtures and Multiple Stressors: Same but Different?
This review highlights the parallels between chemical mixture research and multiple stressor ecology, arguing that both fields face similar challenges in predicting joint effects and would benefit from integrated frameworks combining chemical and non-chemical stressor assessments.
Chemical pollution and microbiomes responses
This paper reviewed how chemical pollution affects microbial community composition and function across different environments. Exposure to pollutants including plastics, heavy metals, and pesticides can disrupt microbial diversity and the ecosystem services microbes provide. The review calls for greater integration of microbiome science into environmental risk assessment.
Common issues of data science on the eco-environmental risks of emerging contaminants.
This review examines common methodological pitfalls in data science approaches to emerging contaminants research, highlighting issues such as data leakage, inadequate ecological complexity, and over-reliance on laboratory data. Researchers argue that future work should integrate ensemble models, spatiotemporal causal frameworks, and field-based validation to close gaps between data-driven predictions and real-world environmental outcomes.
Metabolomics-Based Insights Into the Toxicological Effects and Mechanisms of Microplastics: A Comprehensive Review.
This review of existing research shows that microplastics—tiny plastic particles found everywhere in our environment—can harm multiple body systems including the gut, brain, and reproductive organs. Scientists used a technique called metabolomics (studying how our body processes chemicals) to discover that microplastics disrupt normal metabolism, potentially affecting everything from digestion and brain function to fertility and child development. This research helps explain why microplastic pollution may be a serious health threat that requires urgent attention and solutions.
A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics
This review examines how environmental chemicals, including contaminants associated with plastics, can disrupt human metabolism and contribute to conditions like obesity and diabetes. Researchers mapped the connections between chemical exposure and changes in metabolic biomarkers that signal disease risk. The study highlights the emerging field of metabolism-disrupting chemicals and the importance of understanding how everyday environmental exposures influence long-term metabolic health.