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61,005 resultsShowing papers similar to Adverse biological effects of ingested polystyrene microplastics using Drosophila melanogaster as a model in vivo organism
ClearExposure of polystyrene microplastics induces oxidative stress and physiological defects in Drosophila melanogaster
Researchers used fruit flies as a model organism to study the effects of polystyrene microplastics and found that dietary exposure caused significant oxidative stress at both tested concentrations. The microplastics impaired climbing ability in adult flies and disrupted normal development patterns during the pupal stage. The study suggests that microplastic ingestion can trigger oxidative damage and physiological defects even in relatively simple organisms.
Polystyrene microplastics alter physiological parameters in the Drosophila model
Researchers investigated the effects of polystyrene micro- and nanoplastics on fruit flies (Drosophila melanogaster) and found dose- and size-dependent toxicity at both larval and adult stages. Exposure caused significant behavioral impairments, elevated markers of cellular stress, and activated key stress response genes, indicating that polystyrene microplastics induce oxidative stress and cellular damage.
Polystyrene micro- and nanoplastics affect locomotion and daily activity ofDrosophila melanogaster
Uptake and effects of polystyrene micro- and nanospheres on Drosophila melanogaster were studied, finding that both sizes of plastic particles affected locomotion and daily activity patterns. The results suggest that microplastic and nanoplastic ingestion can disrupt behavioral functions in the fruit fly model.
Metabolic effects of dietary exposure to polystyrene microplastic and nanoplastic in fruit flies
Researchers used fruit flies as a model organism to study the metabolic effects of ingesting polystyrene microplastic and nanoplastic particles at environmentally relevant doses. They found that both particle sizes disrupted metabolic processes, with nanoplastics causing more pronounced changes in energy storage and lipid metabolism. The study suggests that dietary exposure to plastic particles, even at levels found in the environment, can meaningfully alter metabolic physiology.
Plastic Fly: What Drosophila melanogaster Can Tell Us about the Biological Effects and the Carcinogenic Potential of Nanopolystyrene
Researchers used fruit flies as a model organism to investigate whether polystyrene nanoplastics can cause genetic damage and promote tumor growth. They found that nanoplastic exposure led to DNA damage and increased tumor formation in the flies, with effects worsening at higher concentrations. The study suggests that nanoplastics commonly found in food packaging may carry cancer-promoting potential that warrants further investigation.
Effects of polystyrene microplastic ingestion on development, adult fitness, and reproductive success of Culex quinquefasciatus and Anopheles quadrimaculatus
Researchers fed polystyrene microplastics to Drosophila melanogaster and measured effects on larval development, adult fitness, and reproductive success across generations, finding that MP ingestion impaired multiple fitness traits and that some effects persisted into subsequent generations.
Size-dependent and sex-specific negative effects of micro- and nano-sized polystyrene particles in the terrestrial invertebrate model Drosophila melanogaster
Fruit flies exposed to low doses of polystyrene micro and nanoparticles for 28 days showed tissue damage in their gut, ovaries, and testes, with smaller particles causing more harm. The plastics triggered oxidative stress and cell death in gut tissue, though reproduction was not significantly affected at these doses. This study, using a well-established model organism, suggests that even low-level, long-term exposure to tiny plastic particles can damage internal organs, with potential implications for other species including humans.
Hazard assessment of ingested polystyrene nanoplastics in Drosophila larvae
Researchers assessed the hazard of ingested polystyrene nanoplastics in Drosophila larvae, examining effects on gut morphology, oxidative stress, and development to characterize toxicological risks of nanoplastic exposure in a model invertebrate organism.
The effects of microplastics and nanoplastics upon history, policies, and Drosophila melanogaster
This study examined the effects of microplastics and nanoplastics on the fruit fly Drosophila melanogaster, finding that dietary exposure to these pervasive environmental contaminants causes measurable biological harm and making the case for stronger regulatory policies.
Neuromuscular, retinal, and reproductive impact of low-dose polystyrene microplastics on Drosophila
Researchers found that even low doses of polystyrene microplastics impaired neuromuscular signaling, altered retinal function, and reduced reproductive rates in fruit flies, with gene expression changes in key signaling pathways underlying these effects.
Effects of PET microplastics on the physiology of Drosophila
Researchers used Drosophila fruit flies as a model to study the physiological effects of PET microplastics, finding that ingestion affected reproduction, lifespan, and gut function. The study suggests that even common plastic types found in food packaging can have measurable biological effects when consumed by living organisms.
A mini review on exposure of microplastic to Drosophila melanogaster causing sex-specific, transgenerational, locomotory, physiological and developmental effect
This mini-review synthesized studies on how polystyrene and PET microplastics affect Drosophila melanogaster across multiple biological levels including sex-specific responses, physiology, behavior, development, and transgenerational effects. Male Drosophila showed greater sensitivity to microplastics with higher mortality, and effects were both concentration- and size-dependent.
Drosophila melanogaster as a tractable eco-environmental model to unravel the toxicity of micro- and nanoplastics
This review summarizes research using fruit flies as a model to study how micro- and nanoplastics harm living organisms. Studies show these tiny plastic particles cause oxidative stress, inflammation, DNA damage, and reproductive problems in flies, with males being more vulnerable than females -- findings that may help us understand similar risks in humans.
Transgenerational effects on development following microplastic exposure in Drosophila melanogaster
Researchers fed Drosophila melanogaster flies plastic-supplemented food and found that while treated flies showed changes in fertility and sex ratio, their unexposed offspring had shorter larval development and reduced adult size, demonstrating transgenerational developmental effects from parental microplastic exposure.
Toxicological Profile of Polyethylene Terephthalate (PET) Microplastic in Ingested Drosophila melanogaster (Oregon R+) and Its Adverse Effect on Behavior and Development
Researchers fed PET microplastics to fruit flies and found that the particles accumulated in their bodies and caused dose-dependent declines in movement, climbing ability, and survival rates. Higher microplastic concentrations also slowed the flies' development from larvae to adults. While fruit flies are a simple model organism, these behavioral and developmental effects suggest that chronic microplastic ingestion could impair neurological and physiological functions in animals exposed through their diet.
Polystyrene Microplastic Beads Caused Cellular Alterations in midgut cells and Sex-Specific Toxic Effects on Survival, Starvation Resistance, and Excretion of the Model Insect Drosophila melanogaster
Researchers exposed the model insect Drosophila melanogaster to polystyrene microplastic beads (2 µm) at concentrations of 0.005, 0.05, and 0.5 µg/ml and found dose-dependent cellular alterations in midgut cells along with sex-specific effects on survival, starvation resistance, and excretion. The study extends microplastic toxicity evidence to terrestrial invertebrates, highlighting that even low concentrations can disrupt digestive physiology in a widely-used model organism.
No evidence for behavioral or physiological effects of nanoplastics ingestion in the fruit fly Drosophila melanogaster
Researchers exposed Drosophila melanogaster to low and high concentrations of nanoplastics (1 µg/g and 1 mg/g) across several generations and measured emergence rate, mitochondrial activity, metabolism, body mass, and locomotion. No significant behavioral or physiological effects were detected, suggesting Drosophila may be less sensitive to nanoplastics than aquatic species.
New insights into the reproductive hazards posed by polystyrene nanoplastics
Researchers used fruit flies as a model to study how polystyrene nanoplastics affect reproductive health. They found that nanoplastics accumulated in ovaries, testes, and even individual eggs and sperm cells, causing physical damage to reproductive organs and reducing fertility. The study suggests that nanoplastic contamination can directly interfere with reproduction by physically accumulating within reproductive tissues and gametes.
Intake of polyamide microplastics affects the behavior and metabolism of Drosophila
Researchers found that exposure to polyamide microplastics altered feeding behaviour, reduced triglyceride and protein levels, and disrupted metabolism in Drosophila, with effects differing between sexes and increasing in severity at higher microplastic concentrations.
Interactions of ingested polystyrene microplastics with heavy metals (cadmium or silver) as environmental pollutants: a comprehensive in vivo study using drosophila melanogaster
This study used fruit flies to investigate how polystyrene microplastics interact with two heavy metal pollutants — cadmium and silver — after ingestion. The combined exposures demonstrated that microplastics can alter the toxic effects of heavy metals, supporting the concern that microplastics act as carriers that change how harmful metals affect living organisms.
Changes in the wing shape and size in fruit flies exposed to micro and nanoplastics
Researchers exposed fruit flies to polystyrene nano- and microplastics during development and then measured changes in wing shape and size using geometric morphometrics. They found that exposed flies had altered wing dimensions compared to controls, with effects varying between males and females. The study demonstrates that plastic particle exposure during early development can produce measurable physical changes in organisms.
Polypropylene microplastics affect the physiology in Drosophila model
Researchers found that polypropylene microplastics negatively affected the physiology of Drosophila fruit flies, complementing earlier work on polyethylene terephthalate microplastics and demonstrating that different polymer types can impair organism health.
Reproductive toxicity of polystyrene nanoplastics in Drosophila melanogaster under multi-generational exposure
Researchers exposed fruit flies to polystyrene nanoplastics across five consecutive generations and found increasing reproductive harm over time, including reduced egg laying and offspring survival. The damage worsened with each generation even at the same exposure levels, suggesting cumulative effects. The study indicates that nanoplastic exposure may pose growing reproductive risks across generations of organisms.
High-concentration polyethylene and polystyrene microplastics co-exposure shorten insect lifespan and impose ecological risk: Multi-omics evidence from Drosophila melanogaster
Researchers used fruit flies as a model organism to study how co-exposure to high concentrations of polyethylene and polystyrene microplastics affects insect lifespan. Multi-omics analysis revealed that microplastic co-exposure significantly shortened lifespan and disrupted key biological pathways, suggesting potential ecological risks from cumulative microplastic exposure in the environment.