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Papers
61,005 resultsShowing papers similar to Innovative Multi-omic Strategies to Explore Micro- and Nanoplastic Effects
ClearMulti-Omics Approach on the Ecotoxicological Assessment of Microplastics
This review examines the application of multi-omics approaches — including genomics, transcriptomics, proteomics, and metabolomics — to the ecotoxicological assessment of microplastics in living organisms. The authors synthesize how these integrated molecular tools are advancing understanding of the mechanistic pathways by which microplastics disrupt biological systems, offering a more comprehensive picture than single-endpoint toxicity studies.
A critical viewpoint on current issues, limitations, and future research needs on micro- and nanoplastic studies: From the detection to the toxicological assessment.
This critical review examines the current methods for detecting and characterizing micro- and nanoplastics in various environmental samples, as well as reported toxic effects from in vivo and in vitro studies. The authors found that while substantial effort has been made to understand microplastic behavior, the scientific community is still far from a complete understanding of how these particles behave in biological systems. The review calls for improved standardized protocols and more studies focused on uptake kinetics, accumulation, and biodistribution.
Molecular LandscapeRemodeling Unravels the Cross-Linksof Microplastics-Induced Lipidomic Fluctuations,Nutrient Disorders and Energy Disarrangements
This study examined how polypropylene microplastics accumulate in and damage the mouse liver, using integrated lipidomics and transcriptomics to map the molecular landscape of microplastic-induced lipid disruption and metabolic dysfunction.
A metabolomics perspective on the effect of environmental micro and nanoplastics on living organisms: A review
This review examines how scientists use metabolomics, the study of small molecules produced by cellular processes, to understand the toxic effects of microplastics and nanoplastics on living organisms. The research shows that these plastic particles disrupt metabolism in consistent ways across species, affecting energy production, fat processing, and amino acid pathways. These shared metabolic disruptions across different organisms suggest that microplastics could cause similar metabolic problems in humans.
Molecular LandscapeRemodeling Unravels the Cross-Linksof Microplastics-Induced Lipidomic Fluctuations,Nutrient Disorders and Energy Disarrangements
Researchers used combined lipidomic and transcriptomic analysis to demonstrate that polypropylene microplastics accumulated in mouse liver and disrupted key metabolic pathways including lipid biosynthesis, cholesterol metabolism, and energy homeostasis.
Micro-and Nanoplastic-Induced Biochemical Toxicity: Emerging Mechanisms and Health Risks Across Biological Systems
This comprehensive review synthesizes current understanding of how micro- and nanoplastics cause biochemical toxicity across biological systems, from plants and invertebrates to vertebrates and humans. Key mechanisms include oxidative stress, membrane disruption, immune activation, genotoxicity, endocrine disruption, and microbiome perturbation, all modulated by particle size, shape, and surface chemistry. The authors highlight critical gaps in standardization, chronic low-dose effect data, and the need for translatable biomarkers for risk assessment.
Integrated transcriptomic and metabolomic analyses to decipher the regulatory mechanisms of polystyrene nanoplastic-induced metabolic disorders in hepatocytes
Using combined transcriptomic and metabolomic analysis, this study found that polystyrene nanoplastics disrupt lipid and amino acid metabolism in hepatocytes, identifying key regulatory genes and providing data relevant to assessing health risks from nanoplastic exposure.
Micro- and nanoplastics: origin, sources of intake and impact on human health (literature review)
This literature review synthesizes mechanisms by which micro- and nanoplastics interact with living organisms, examining their physicochemical properties, routes of human exposure, and documented health effects across multiple organ systems.
Ecotoxicoproteomic assessment of microplastics and plastic additives in aquatic organisms: A review
This review examines how proteomics — the large-scale study of proteins — is being applied to understand the toxic effects of microplastics and plastic additives on aquatic organisms, and how this data can feed into adverse outcome pathway frameworks for ecological risk assessment.
Molecular LandscapeRemodeling Unravels the Cross-Linksof Microplastics-Induced Lipidomic Fluctuations,Nutrient Disorders and Energy Disarrangements
Mouse liver studies with polypropylene microplastics revealed interconnected disruptions in lipid metabolism, nutrient processing, and energy balance, with proteomic and transcriptomic data highlighting the complexity of hepatic responses to chronic microplastic exposure.
Omics approaches in environmental effect assessment of engineered nanomaterials and nanoplastics
This review highlights how advanced biological analysis techniques, known as omics approaches, are being used to better understand how engineered nanomaterials and nanoplastics affect living organisms at the molecular level. These methods can reveal hidden toxic effects that traditional tests might miss. The research is important for developing more accurate risk assessments of nanoplastic exposure on environmental and human health.
Molecular LandscapeRemodeling Unravels the Cross-Linksof Microplastics-Induced Lipidomic Fluctuations,Nutrient Disorders and Energy Disarrangements
Researchers examined polypropylene microplastic retention in mouse liver using lipidomics and transcriptomics, finding that chronic exposure disrupted lipid metabolism, cholesterol turnover, and antioxidant defense, with high-dose treatment causing regional liver fibrosis.
Molecular Landscape Remodeling Unravels the Cross-Links of Microplastics-Induced Lipidomic Fluctuations, Nutrient Disorders and Energy Disarrangements
Researchers fed mice polypropylene microplastics chronically and used lipidomics and transcriptomics to show that microplastics accumulated in the liver and disrupted lipid metabolism, cholesterol homeostasis, and redox balance, with high doses causing fibrotic liver changes.
Nanoplastics in biological systems: What laboratory mechanisms reveal about real-world toxicity
Researchers developed a mechanistic-scaling framework reconciling high-dose laboratory toxicity data for nanoplastics with low-dose environmental realities, arguing that core injury pathways—oxidative stress, lysosomal rupture, mitochondrial dysfunction—remain active at environmental concentrations and are amplified by particle aging and co-contaminant loading.
Health impacts of micro- and nanoplastics: key influencing factors, limitations, and future perspectives
This review systematically analyzed how the physicochemical properties of micro- and nanoplastics — including size, shape, surface charge, and polymer type — determine their toxicological impacts across biological systems. The authors argue that property-based frameworks are essential for predicting MNP health risks and designing relevant research.
Molecular LandscapeRemodeling Unravels the Cross-Linksof Microplastics-Induced Lipidomic Fluctuations,Nutrient Disorders and Energy Disarrangements
This study assessed the liver toxicity of polypropylene microplastics in mice using combined lipidomics and transcriptomics, identifying disrupted lipid metabolism, altered cholesterol handling, and fibrotic tissue remodeling as key pathological outcomes.