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20 resultsShowing papers similar to Polyethylene microplastics cooperate with Helicobacter pylori to promote gastric injury and inflammation in mice
ClearSynergistic toxicity of nanoplastics and Helicobacter pylori on digestive system in mice
Researchers studied the combined toxic effects of nanoplastics and the stomach bacterium Helicobacter pylori on the digestive systems of mice. They found that co-exposure caused more severe damage to the stomach, colon, and liver than either stressor alone, including increased inflammation and disrupted gut barrier function. The study suggests that nanoplastic contamination may worsen the health effects of common gut infections.
Relationship Between Human Microbiome and Helicobacter pylori
This review explores the complex relationship between Helicobacter pylori, the bacterium that causes stomach ulcers, and the broader human gut microbiome. While not directly about microplastics, it provides important context because microplastic exposure is known to alter gut bacteria composition. Understanding how the gut microbiome interacts with specific pathogens is relevant to assessing whether microplastic-driven changes in gut bacteria could make people more vulnerable to infections.
Interaction of Polystyrene Nanoplastics and Helicobacter pylori Modulates Gastric Cancer Cellular Functions and Metastasis
Researchers investigated the combined effects of polystyrene nanoplastics and H. pylori bacteria on gastric cancer cells. In laboratory experiments, co-exposure reduced cancer cell viability, increased cell death, and enhanced autophagy. However, in animal models the combined exposure showed an antagonistic effect, where H. pylori actually reduced the metastasis-promoting effects of nanoplastics alone, suggesting complex interactions between nanoplastics and bacterial pathogens in the gut environment.
Interaction of Polystyrene Nanoplastics and Helicobacter pylori Modulates Gastric Cancer Cellular Functions and Metastasis
Researchers examined whether polystyrene nanoplastics and Helicobacter pylori bacteria can jointly enter gastric cancer cells and influence cancer progression. The study found that combined exposure to nanoplastics and H. pylori modulated cell proliferation, apoptosis, autophagy, and metastasis in gastric cancer cells, suggesting that nanoplastic contamination may interact with bacterial infections to affect cancer-related cellular processes.
Interaction of Polystyrene Nanoplastics and Helicobacter pylori Modulates Gastric Cancer Cellular Functions and Metastasis
Researchers examined whether polystyrene nanoplastics and Helicobacter pylori bacteria can jointly enter gastric cancer cells and influence cancer progression. The study found that combined exposure to nanoplastics and H. pylori modulated cell proliferation, apoptosis, autophagy, and metastasis in gastric cancer cells, suggesting that nanoplastic contamination may interact with bacterial infections to affect cancer-related cellular processes.
Interaction of Polystyrene Nanoplastics and Helicobacter pylori Modulates Gastric Cancer Cellular Functions and Metastasis
Researchers examined whether polystyrene nanoplastics and Helicobacter pylori bacteria can jointly enter gastric cancer cells and influence cancer progression. The study found that combined exposure to nanoplastics and H. pylori modulated cell proliferation, apoptosis, autophagy, and metastasis in gastric cancer cells, suggesting that nanoplastic contamination may interact with bacterial infections to affect cancer-related cellular processes.
Interaction of Polystyrene Nanoplastics and Helicobacter pylori Modulates Gastric Cancer Cellular Functions and Metastasis
Researchers examined whether polystyrene nanoplastics and Helicobacter pylori bacteria can jointly enter gastric cancer cells and influence cancer progression. The study found that combined exposure to nanoplastics and H. pylori modulated cell proliferation, apoptosis, autophagy, and metastasis in gastric cancer cells, suggesting that nanoplastic contamination may interact with bacterial infections to affect cancer-related cellular processes.
Charge-dependent effects of nanoplastics on Helicobacter pylori virulence and gastric pathogenesis
Researchers infected mice with Helicobacter pylori and co-exposed them to positively charged, negatively charged, or neutral polystyrene nanoplastics, then assessed gastric pathogenesis. Positively charged nanoplastics most strongly enhanced H. pylori virulence, gastric inflammation, and ulceration, identifying surface charge as a key determinant of how nanoplastics interact with gut pathogens.
Microplastic in Gastric Fasting Liquid and Associated Gastric Pathology
This study found microplastic particles in gastric fluid samples collected from patients undergoing routine stomach examinations, and noted associations between microplastic presence and gastric pathologies including H. pylori infection, intestinal metaplasia, and inflammation. The findings provide direct clinical evidence that microplastics accumulate in the human stomach and may be linked to gastric disease, though causality is not yet established. This is an important step toward understanding whether microplastic ingestion contributes to gastrointestinal health problems in humans.
Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice
Researchers fed mice different concentrations of polyethylene microplastics for five weeks and found significant changes in gut bacteria composition and signs of intestinal inflammation. Higher doses increased bacterial diversity and altered the balance of specific bacterial species, while triggering immune responses and inflammation in the colon and duodenum. The study provides evidence that microplastic ingestion can disrupt the gut microbiome and promote intestinal inflammation in mammals.
Oral exposure to polyethylene microplastics exacerbates the effects of a Western-style diet on the digestive tract of adult male mice
Researchers investigated how oral exposure to polyethylene microplastics interacts with a Western-style diet to affect the digestive tract of mice over 90 days. The study found that microplastics exacerbated diet-related intestinal disruption, suggesting that dietary context plays an important role in determining the health impact of microplastic ingestion.
Polystyrene microplastics exposure increases the disruption of intestinal barrier integrity and gut microbiota homeostasis during obesity and aging
Researchers found that polystyrene microplastic exposure worsened intestinal barrier dysfunction in mice on high-fat diets, with the combination of obesity and microplastic exposure producing greater gut permeability and inflammation than either factor alone, suggesting compounding risks in metabolically vulnerable individuals.
Influence of Microplastics on Morphological Manifestations of Experimental Acute Colitis
Researchers fed polystyrene microplastics to mice for six weeks and found that healthy mice developed changes in their colon lining, including altered mucus composition and immune cell populations. When mice with experimentally induced colitis also consumed microplastics, their intestinal inflammation was significantly more severe. The study suggests that microplastic exposure may worsen inflammatory bowel conditions.
Polyethylene terephthalate microplastics affect gut microbiota distribution and intestinal damage in mice
Mice exposed to PET microplastics, the type commonly found in plastic bottles, developed intestinal inflammation, changes in gut bacteria, and signs of a weakened gut barrier. Even at relatively low doses, the microplastics increased liver stress markers and disrupted the protective mucus layer in the colon, suggesting that everyday PET plastic exposure could contribute to digestive health problems.
Long-term exposure to polystyrene microplastics promotes HFD-induced obesity in mice through exacerbating microbiota dysbiosis
Researchers found that long-term polystyrene microplastic exposure worsened high-fat-diet-induced obesity in mice by exacerbating gut microbiota dysbiosis, suggesting microplastic ingestion may amplify metabolic disease risk through disruption of the gut microbiome.
Microplastics in our diet: complementary in vitro gut and epithelium models to understand their fate in the human digestive tract.
Researchers used complementary in vitro gut models to study how microplastics behave during human digestion, finding that digestive conditions alter microplastic surface properties and their interactions with gut cells. The work advances understanding of how ingested microplastics may affect the human digestive system.
Polystyrene microplastics exacerbated the toxicity of okadaic acid to the small intestine in mice
Researchers studied the combined effects of polystyrene microplastics and okadaic acid, a marine toxin, on the small intestines of mice. They found that co-exposure significantly worsened intestinal damage compared to either contaminant alone, increasing oxidative stress and disrupting the gut barrier. The study suggests that microplastics may amplify the harmful effects of naturally occurring marine toxins when both are consumed through seafood.
Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction
Researchers investigated how micro- and nanoplastics disrupt gut barrier function in mice, finding that different surface chemistries caused varying levels of damage. The study suggests that these plastic particles harm the gut by altering the gut microbiome, which then leads to inflammation and weakening of the intestinal barrier that normally keeps harmful substances out of the body.
Polystyrene microplastics aggravate inflammatory damage in mice with intestinal immune imbalance
Researchers found that polystyrene microplastics caused significantly worse inflammatory damage in mice that already had compromised intestinal immune systems compared to healthy mice. The microplastics increased inflammatory markers, disrupted gut bacteria, and caused more severe tissue damage in the vulnerable animals. The study suggests that individuals with pre-existing gut health issues may be more susceptible to the harmful effects of microplastic exposure.
Polystyrene microplastics aggravate radiation-induced intestinal injury in mice
Researchers found that polystyrene microplastics significantly worsened radiation-induced intestinal injury in mice undergoing abdominal radiation treatment. The microplastics increased tissue damage in the small intestine and disrupted the gut microbiome, reducing beneficial bacteria while increasing potentially harmful ones. The study suggests that microplastic exposure could be an important factor to consider for patients undergoing radiation therapy.