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61,005 resultsShowing papers similar to Combined exposure to microplastics and tetracycline leads to impaired skeletal development in young mice by the microbiota gut bone axis
ClearEffects of microplastics and tetracycline induced intestinal damage, intestinal microbiota dysbiosis, and antibiotic resistome: metagenomic analysis in young mice
Young mice exposed to both polystyrene microplastics and the antibiotic tetracycline suffered worse intestinal damage than those exposed to either pollutant alone. The combination severely disrupted the gut barrier, altered gut bacteria, and increased antibiotic resistance genes in the intestines. This is especially concerning for children, whose developing gut systems may be more vulnerable to the combined effects of microplastics and antibiotics commonly found in the environment.
Effects of microplastics and tetracycline on intestinal injury in mice
Researchers found that mice exposed to both microplastics and the antibiotic tetracycline suffered more intestinal damage than those exposed to either pollutant alone. The combined exposure caused distinct injuries across different segments of the intestine and disrupted gut bacteria composition. This is concerning because humans are commonly exposed to both microplastics and antibiotic residues through food and water.
Microplastics combined with tetracycline in soils facilitate the formation of antibiotic resistance in the Enchytraeus crypticus microbiome
Soil invertebrates (Enchytraeus crypticus) were exposed to microplastics and tetracycline alone and in combination; combined exposure promoted greater shifts in gut microbiome composition and higher levels of antibiotic resistance genes than either stressor alone, suggesting microplastics exacerbate antibiotic resistance spread in soil.
Gut–Liver Axis Mediates the Combined Hepatointestinal Toxicity of Triclosan and Polystyrene Microplastics in Mice: Implications for Human Co-Exposure Risks
Mice co-exposed to the antimicrobial triclosan and polystyrene microplastics showed markedly worse intestinal and liver damage than those exposed to either contaminant alone, with gut microbiome disruption identified as a key mediating mechanism.
Gut microbiota related response of Oryzias melastigma to combined exposure of polystyrene microplastics and tetracycline
Researchers exposed estuarine fish to polystyrene microplastics and the antibiotic tetracycline, both alone and in combination, for four weeks. The combined exposure caused more severe disruption to gut bacteria and liver tissue than either pollutant alone, with microplastics appearing to worsen the effects of tetracycline. The study suggests that the co-occurrence of microplastics and antibiotics in coastal waters may pose greater ecological risks than either contaminant by itself.
Oral exposure of polystyrene microplastics and doxycycline affects mice neurological function via gut microbiota disruption: The orchestrating role of fecal microbiota transplantation
Mice exposed to both polystyrene microplastics and the antibiotic doxycycline showed brain inflammation and declines in learning and memory, driven by disruptions to their gut bacteria. Fecal transplants from healthy mice reversed some of these brain effects, confirming the gut-brain connection plays a key role. This suggests that microplastics combined with common antibiotics could harm brain function through changes in the gut microbiome.
Microplasticsand Nanoplastics Cause Thyroid Dysfunctionin Adolescent Mice through the Intestinal Microbiota-Mediated Hypothalamus-Pituitary-ThyroidAxis
Dietary exposure to PP and PET micro/nanoplastics in adolescent mice caused thyroid dysfunction by disrupting the gut microbiota-mediated hypothalamus-pituitary-thyroid axis, with gut microbiota transplantation experiments confirming the causal role of microbiome changes.
Microplastics and Nanoplastics Cause Thyroid Dysfunction in Adolescent Mice through the Intestinal Microbiota-Mediated Hypothalamus-Pituitary-Thyroid Axis
Adolescent mice exposed to PP and PET micro/nanoplastics in diet showed reduced thyroid hormone levels, and fecal microbiota transplantation experiments confirmed that gut microbiota mediated thyroid dysfunction via the intestinal-hypothalamus-pituitary-thyroid axis.
Polystyrene microplastics exposure increases the disruption of intestinal barrier integrity and gut microbiota homeostasis during obesity and aging
Researchers found that polystyrene microplastic exposure worsened intestinal barrier dysfunction in mice on high-fat diets, with the combination of obesity and microplastic exposure producing greater gut permeability and inflammation than either factor alone, suggesting compounding risks in metabolically vulnerable individuals.
Adolescent exposure to micro/nanoplastics induces cognitive impairments in mice with neuronal morphological damage and multi-omic alterations
Adolescent mice exposed to polystyrene nanoplastics showed significant memory and learning problems, along with neuron loss and reduced new brain cell growth in the hippocampus. The nanoplastics also disrupted gut bacteria and brain chemistry, with strong links found between gut microbiome changes and brain metabolic disruption, suggesting that plastic exposure during youth may impair brain development through the gut-brain connection.
Meta-analysis unravels the complex combined toxicity of microplastics and antibiotics in aquatic ecosystems
A meta-analysis of 730 datasets found that microplastics amplify antibiotic accumulation in aquatic organisms and worsen effects on growth, development, and immune function, but paradoxically appear to mitigate reproductive toxicity from antibiotics. The impact depends on biological response pathway, microplastic concentration, antibiotic properties, and exposure time, with an inverse relationship between antibiotic toxicity and both microplastic concentration and exposure duration.
Combined effect of microplastic and triphenyltin: Insights from the gut-brain axis
Researchers investigated the individual and combined toxicity of microplastics and triphenyltin, an organotin compound, in common carp by examining effects along the gut-brain axis. The study found that co-exposure to microplastics and triphenyltin produced combined toxic effects on the gut microbiome and brain function, suggesting that microplastics may enhance the toxicity of other environmental pollutants through their ability to adsorb contaminants.
Combined effects of micro-/nano-plastics and oxytetracycline on the intestinal histopathology and microbiome in zebrafish (Danio rerio)
Researchers studied the combined effects of micro- and nano-sized plastics with the antibiotic oxytetracycline on zebrafish intestines over 30 days. Nano-sized plastics caused more intestinal damage than micro-sized ones, and combined exposures altered gut bacterial communities and increased antibiotic resistance genes. The findings suggest that the co-occurrence of plastic particles and antibiotics in aquatic environments may have compounding negative effects on fish gut health.
Polystyrene microplastics arrest skeletal growth in puberty through accelerating osteoblast senescence
Researchers found that polystyrene microplastics accumulated in the bones of mice during puberty, leading to reduced body and bone length and impaired bone structure. The microplastics accelerated premature aging (senescence) of bone-building cells called osteoblasts, suppressing their ability to form new bone. The study suggests that microplastic exposure during critical growth periods may pose a risk to skeletal development.
Bridging relevance between microplastics, human health and bone metabolism: Emerging threats and research directions
Researchers reviewed how microplastics — tiny plastic fragments that accumulate in tissues throughout the body — may disrupt bone metabolism by triggering inflammation, oxidative stress, and hormonal interference, raising concern that widespread microplastic exposure could contribute to bone diseases like osteoporosis.
Exposure to microplastics reduces the bioaccumulation of sulfamethoxazole but enhances its effects on gut microbiota and the antibiotic resistome of mice
Researchers used a mouse model to study how microplastics affect the bioaccumulation and health impacts of the antibiotic sulfamethoxazole. While microplastics reduced the overall tissue accumulation of the antibiotic, they enhanced its disruptive effects on gut microbiota and increased antibiotic resistance genes. The findings suggest that microplastics may alter how pharmaceuticals interact with the body in ways that could promote antimicrobial resistance.
Combined exposure to microplastics and cadmium alters gut microbiota composition in preschool children: A cross-sectional study
A cross-sectional study of preschool children found that combined exposure to microplastics and cadmium was associated with altered gut microbiota composition. The findings suggest that dietary co-exposure to these two contaminants has joint effects on early-life gut health beyond what either pollutant causes alone.
Long-Term Exposure to Polystyrene Microspheres and High-Fat Diet-Induced Obesity in Mice: Evaluating a Role for Microbiota Dysbiosis.
A long-term mouse study examined how chronic exposure to polystyrene microspheres interacts with a high-fat diet to affect obesity-related outcomes, finding that microplastics worsened metabolic disruption and fat accumulation compared to diet alone. The results raise concern that microplastic exposure may be an environmental factor contributing to the global obesity epidemic.
Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction
Mice were exposed to polyethylene terephthalate nanoparticles, and researchers used histopathology, metabolomics, and metagenomics to track downstream effects. Nanoplastic ingestion caused severe metabolic disruption—including weight loss, organ atrophy, and liver-intestinal dysfunction—by remodeling the bile acid–gut microbiota axis.
Long-term exposure to polystyrene microplastics promotes HFD-induced obesity in mice through exacerbating microbiota dysbiosis
Researchers found that long-term polystyrene microplastic exposure worsened high-fat-diet-induced obesity in mice by exacerbating gut microbiota dysbiosis, suggesting microplastic ingestion may amplify metabolic disease risk through disruption of the gut microbiome.
Continuous oral exposure to micro- and nanoplastics induced gut microbiota dysbiosis, intestinal barrier and immune dysfunction in adult mice
Researchers fed mice micro- and nanoplastics at environmentally relevant levels and found significant gut damage, including disrupted gut bacteria, weakened intestinal barriers, and reduced immune function. The ratio of beneficial to harmful gut bacteria shifted, and immune cells in the gut decreased. Importantly, the duration of exposure and the size of plastic particles mattered more than the amount consumed, suggesting even low-level long-term exposure could harm gut health.
Combined effects of microplastics and chlortetracycline on the intestinal barrier, gut microbiota, and antibiotic resistome of Muscovy ducks (Cairina moschata)
Researchers fed Muscovy ducks polystyrene microplastics and the antibiotic chlortetracycline, alone and together, for 56 days. The combination damaged the intestinal barrier, disrupted gut bacteria, and increased antibiotic resistance genes more than either contaminant alone. This is concerning because waterfowl in contaminated environments face simultaneous exposure to microplastics and antibiotics, which may accelerate the spread of antibiotic resistance.
[Effects of microplastics exposure in development of mineralized tissues].
This review examined evidence that microplastic exposure affects the formation and development of mineralized tissues including bone and teeth, finding that MP-induced oxidative stress and inflammation may disrupt mineralization processes and raise concern for skeletal health from environmental plastic exposure.
The combined effect of microplastics and tetracycline on soil microbial communities and ARGs
Researchers studied how simultaneous exposure to microplastics and tetracycline affects soil microbial communities, finding that the combination disrupted microbial diversity, altered functional gene expression, and promoted horizontal transfer of antibiotic resistance genes beyond the effects of either pollutant alone.