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Exposure to microplastics reduces the bioaccumulation of sulfamethoxazole but enhances its effects on gut microbiota and the antibiotic resistome of mice

Chemosphere 2022 57 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Jin Liu, Jing Ding, Jing Ding, Jing Ding, Jing Ding, Jing Ding, Jing Ding, Anqi Sun, Anqi Sun, Anqi Sun, Anqi Sun, Jin Liu, Min Lv, Jin Liu, Yunqing Wang, Jin Liu, Min Lv, Min Lv, Min Lv, Min Lv, Yunqing Wang, Yunqing Wang, Yunqing Wang, Yunqing Wang, Yunqing Wang, Yunqing Wang, Min Lv, Yunqing Wang, Jin Liu, Yunqing Wang, Jing Ding, Jing Ding, Min Lv, Anqi Sun, Yunqing Wang, Jin Liu, Anqi Sun, Yunqing Wang, Anqi Sun, Lingxin Chen Jing Ding, Jing Ding, Jing Ding, Lingxin Chen Yunqing Wang, Lingxin Chen Yunqing Wang, Jin Liu, Lingxin Chen Jin Liu, Xianbo Chang, Yunqing Wang, Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Yunqing Wang, Yunqing Wang, Xianbo Chang, Jin Liu, Lingxin Chen Lingxin Chen Min Lv, Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Jing Ding, Xianbo Chang, Xianbo Chang, Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Min Lv, Lingxin Chen Min Lv, Lingxin Chen Lingxin Chen Lingxin Chen Min Lv, Min Lv, Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen

Summary

Researchers used a mouse model to study how microplastics affect the bioaccumulation and health impacts of the antibiotic sulfamethoxazole. While microplastics reduced the overall tissue accumulation of the antibiotic, they enhanced its disruptive effects on gut microbiota and increased antibiotic resistance genes. The findings suggest that microplastics may alter how pharmaceuticals interact with the body in ways that could promote antimicrobial resistance.

Body Systems

Cardiovascular Hepatic Immune Renal Respiratory

Models

Mouse

Microplastics (MPs) have aroused a global health concern and their coexistence with antibiotics is inevitable. However, how MPs would affect the bioaccumulation and risks of antibiotics in humans remains poorly understood. Here a mouse model was used, and through dietary exposure, we observed that while the relative distributions of sulfamethoxazole (SMX) in tissues were relatively stable, MPs significantly reduced the bioaccumulation of SMX in mice tissues (liver, lung, spleen, heart and kidney). Notably, while SMX and MPs showed a differential effect, MPs could exacerbate the effects of SMX on gut microbiota and antibiotic resistance gene (ARG) profile, with the relative abundances of sulfonamide resistance genes and multidrug genes being significantly increased. We further identified that shifts in gut microbiota contributed to the changes in ARG profiles in mice. Combined, our results demonstrate that MPs reduced the bioaccumulation of SMX, but they enhanced its effects on gut microbiota and the antibiotic resistome of mice, indicating they might have high risks to humans.

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