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61,005 resultsShowing papers similar to Ursolic Acid Suppresses Proliferation and Elicits Apoptosis of Laryngeal Carcinoma Cell HEp-2 through Activation of ROS Synthesis and Inhibition of Multiple Signaling Pathways
ClearMorroniside Protects Human Granulosa Cells against H2O2-Induced Oxidative Damage by Regulating the Nrf2 and MAPK Signaling Pathways
Researchers found that morroniside protects human ovarian granulosa cells from oxidative damage by activating the Nrf2 antioxidant pathway and reducing apoptosis through regulation of p38 and JNK signaling pathways.
The Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae) Exerts an In Vitro Antimelanoma Effect by Inducing Apoptosis and Modulating the MAPKs, NF-κB, and PKB/AKT Signaling Pathways
Researchers investigated the anticancer potential of an essential oil extracted from Conyza bonariensis against melanoma cells in laboratory experiments. They found that the oil's major compound interacted with key signaling pathways involved in cell survival and induced programmed cell death in melanoma cells. The study suggests this plant-derived compound may warrant further investigation as a potential source of anti-melanoma agents.
Ethanol Extract of Rosa rugosa Ameliorates Acetaminophen-Induced Liver Injury via Upregulating Sirt1 and Subsequent Potentiation of LKB1/AMPK/Nrf2 Cascade in Hepatocytes
Researchers prepared an ethanol extract from Rosa rugosa flower buds and found it significantly reduced liver damage caused by acetaminophen overdose in both cell and mouse models. The extract worked by activating the Sirt1 protein and boosting a protective signaling pathway that counters oxidative stress in liver cells. The study suggests Rosa rugosa extract may have potential as a natural intervention for drug-induced liver injury.
Hesperidin inhibits tobacco smoke‑induced pulmonary cell proliferation and EMT in mouse lung tissues via the p38 signaling pathway
Researchers found that hesperidin, a natural flavonoid compound, inhibits tobacco smoke-induced lung cell proliferation and epithelial-mesenchymal transition in mice by suppressing the p38 signaling pathway, suggesting a potential role in reducing lung cancer risk.
Integration of transcriptomics and metabolomics reveals the mechanism of Lycium barbarum polysaccharides inhibited MCF-7 cell proliferation
Researchers used transcriptomics and metabolomics to investigate how Lycium barbarum polysaccharides inhibit MCF-7 breast cancer cell proliferation, identifying the molecular mechanisms and signaling pathways responsible for the compound's anticancer activity at an optimal dose of 8 mg/mL.
Sakuranetin: A multifaceted study from plant resistance to pharmacological activity
This review synthesized 15 years of research on sakuranetin, a plant flavonoid, covering its biosynthesis, role in plant stress resistance, and pharmacological activities including anti-inflammatory, antiviral, and anticancer properties.
Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage through endothelial cell pyroptosis inhibition
Researchers investigated how the compound Huperzine A affects brain damage following spontaneous subarachnoid hemorrhage in rats. They found that the treatment reduced blood-brain barrier damage and brain swelling by blocking a type of inflammatory cell death in blood vessel cells. The study suggests that Huperzine A may offer protective benefits for brain health after hemorrhagic stroke through its anti-inflammatory and antioxidant properties.
Morroniside protect human granulosa cells against H2O2-induced oxidative damage via regulating Nrf2 and MAPK signaling pathway
This study investigated whether morroniside, a compound from the Cornus plant, can protect ovarian cells from oxidative stress-induced damage. The research found protective effects in lab experiments, relevant to understanding how environmental oxidative stressors—including pollutants like microplastics—may affect female reproductive cells.
Lactiplantibacillus plantarum WB3801 and Lactiplantibacillus plantarum WB3808 Showed Antioxidant Effect and Anti-Apoptosis through Activation of the Keap1/Nrf2/HO-1 Pathway in H 2 O 2 -Induced HT-29 Cells
Researchers evaluated three Lactiplantibacillus plantarum strains isolated from Korean kimchi for cytoprotective effects against hydrogen peroxide-induced oxidative stress in HT-29 intestinal cells. Strains WB3801 and WB3808 activated the Keap1/Nrf2/HO-1 pathway, reduced intracellular ROS, attenuated apoptosis by lowering the Bax/Bcl-2 ratio, and suppressed caspase activation, supporting their potential as functional probiotics for gastrointestinal protection.
Tea Polyphenols Mitigate TBBPA-Induced Renal Injury Through Modulation of ROS-PI3K/AKT-NF-κB Signalling in Carp (Cyprinus carpio)
Researchers found that tea polyphenols, the beneficial compounds in tea, helped protect carp kidneys from damage caused by the flame retardant chemical TBBPA. The tea compounds reduced oxidative stress, inflammation, and cell death in kidney tissue by modulating key signaling pathways. The study suggests that natural antioxidants like those found in tea may help mitigate some of the harmful effects of environmental chemical pollutants on aquatic organisms.
CHEMOPREVENTIVE POTENTIAL OF ALCOHOLIC EXTRACT OF A POLYHERBAL ( Phyllanthus amarus, Euphorbia hirta and Azadirachta indica) RECIPE AGAINST BENZO(a)PYRENE INDUCED LUNG CARCINOGENESIS IN ALBINO MICE
Researchers assessed the chemopreventive potential of an alcoholic extract of a polyherbal preparation including Phyllanthus amarus in a precancerous lesion model, measuring effects on biomarkers of oxidative stress and inflammation. The herbal extract reduced key biomarkers compared to untreated controls, supporting further investigation of plant-derived compounds as adjuncts in cancer chemoprevention.
Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells
Researchers found that oridonin, a natural plant compound, can trigger two different types of cell death simultaneously in bone cancer cells. This dual mechanism makes it effective at suppressing tumor growth in osteosarcoma. The study suggests oridonin could be a promising therapeutic agent for treating this type of bone cancer.
Natural Pyrethrin-Induced Oxidative Damage in Human Liver Cells through Nrf-2 Signaling Pathway
Researchers investigated the toxic effects of natural pyrethrins, a common bio-pesticide, on human liver cells. The study found that pyrethrins induced oxidative damage through the Nrf-2 signaling pathway, suggesting that even natural pesticides may pose risks to liver metabolism at certain exposure levels.
Resveratrol Attenuates Oxidative Stress-Induced Intestinal Barrier Injury through PI3K/Akt-Mediated Nrf2 Signaling Pathway
This study investigated the antioxidant compound resveratrol as a potential treatment for oxidative stress-induced intestinal barrier damage, finding it protected gut lining integrity through a specific cell signaling pathway. While focused on intestinal health generally, the mechanisms studied are relevant to how microplastic exposure can damage gut barriers.
Uncovering the Anticancer Potential of Polydatin: A Mechanistic Insight
This review examines the anticancer mechanisms of polydatin, a natural stilbenoid compound, detailing its ability to inhibit tumor growth through antioxidant, anti-inflammatory, and apoptotic pathways across multiple cancer types.
Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS
Researchers found that combining melatonin (a natural hormone) with erastin (a cell-death inducer) produced synergistic anticancer effects in oral cancer cells by triggering multiple forms of cell death simultaneously, suggesting a potentially safer and more effective treatment strategy.
Comprehensive Transcriptome Profiling of Antioxidant Activities by Glutathione in Human HepG2 Cells
Researchers used DNA microarray analysis to map the full range of genes activated by the antioxidant glutathione in human liver cells under both normal and stressed conditions. They found that glutathione activates protective antioxidant pathways, including the NRF2 system, and regulates a broad set of biological processes beyond its known role. The study provides a comprehensive molecular picture of how glutathione supports liver cell defense against oxidative damage.
Honokiol Microemulsion Causes Stage-Dependent Toxicity Via Dual Roles in Oxidation-Reduction and Apoptosis through FoxO Signaling Pathway
Honokiol microemulsion caused stage-dependent developmental toxicity in zebrafish and rats, with early exposure triggering oxidative stress and later exposure activating apoptosis through the FoxO signaling pathway. These findings establish critical time windows for honokiol toxicity, important safety data as this compound advances through lung cancer clinical trials.
Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells
This review explores how reactive oxygen species (ROS) -- harmful molecules produced during abnormal cell metabolism -- can damage DNA and trigger cancer cell death, making ROS a potential target for cancer treatment. While not directly about microplastics, this is relevant because microplastic exposure is known to increase ROS production in human cells, which could contribute to DNA damage over time.
N-Acetyl-L-Cysteine Ameliorates BPAF-Induced Porcine Sertoli Cell Apoptosis and Cell Cycle Arrest via Inhibiting the ROS Level
Researchers investigated how bisphenol AF, a plastic-derived environmental contaminant, affects testicular Sertoli cells in pigs. The study found that high concentrations of BPAF triggered cell death, cell cycle arrest, and elevated levels of reactive oxygen species, while reducing antioxidant defenses. Evidence indicates that the antioxidant N-acetyl-L-cysteine could block these harmful effects, suggesting that BPAF-induced damage operates through oxidative stress pathways.
Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Bushen Huashi decoction against kidney stones
This study used network pharmacology and laboratory validation to reveal that a traditional Chinese herbal formula (Bushen Huashi decoction) combats kidney stones by modulating estrogen receptor, NRF2/HO-1 antioxidant, and apoptosis signaling pathways.
Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells
Researchers found that quercetin, a natural plant compound, protected mouse ovaries from chemotherapy-induced damage by reducing harmful oxidative stress in mitochondria and suppressing a form of inflammatory cell death called pyroptosis, suggesting it could help preserve fertility in patients undergoing cancer treatment.
The Potential Role and Effective Components of Sanyeqing as the Potential Therapeutic Candidates for IBD and CRC
This review examines the phytochemical constituents of Sanyeqing (a traditional medicinal plant) and their therapeutic potential for inflammatory bowel disease and colorectal cancer, identifying anti-inflammatory and anti-tumor mechanisms that could complement conventional treatments.
Dendrobine Alleviates Cellular Senescence and Osteoarthritis via the ROS/NF-κB Axis
Researchers investigated whether dendrobine, a natural compound from orchids, could reduce cellular aging and osteoarthritis symptoms in lab and animal models. They found that dendrobine decreased oxidative stress and inflammation by suppressing the ROS/NF-kB signaling pathway, which reduced cartilage breakdown and cellular senescence. The study suggests dendrobine may have potential as a therapeutic approach for age-related joint degeneration.