Papers

61,005 results
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Article Tier 2

Toxicity interaction of polystyrene nanoplastics with sulfamethoxazole on the microalgae Chlamydomonas reinhardtii: A closer look at effect of light availability

Researchers studied how light availability influences the combined toxicity of polystyrene nanoplastics and the antibiotic sulfamethoxazole on the microalga Chlamydomonas reinhardtii. The study found that the interaction between these two pollutants was largely antagonistic under low and normal light conditions, as nanoplastics could adsorb the antibiotic and reduce its bioavailability, highlighting the importance of environmental factors in determining combined pollutant toxicity.

2023 Journal of Environmental Management 17 citations
Article Tier 2

Higher toxicity induced by co-exposure of polystyrene microplastics and chloramphenicol to Microcystis aeruginosa: Experimental study and molecular dynamics simulation

Researchers studied what happens when the antibiotic chloramphenicol and polystyrene microplastics are present together in water containing blue-green algae. The study found that the combined exposure was more toxic to the algae than either pollutant alone, disrupting photosynthesis and gene expression. The findings suggest that microplastics and antibiotics may interact in ways that amplify their harmful effects on aquatic ecosystems.

2023 The Science of The Total Environment 38 citations
Article Tier 2

Mechanism of the Synergistic Toxicity of Ampicillin and Cefazoline on Selenastrum capricornutum

Researchers studied how two common antibiotics, ampicillin and cefazolin, work together to harm freshwater algae, finding that their combined effect is worse than either antibiotic alone. The antibiotics disrupted the algae's growth, metabolism, and photosynthesis at the genetic level. While focused on antibiotic pollution rather than microplastics, the study is relevant because microplastics can carry antibiotics through waterways, potentially amplifying these toxic effects on aquatic ecosystems.

2024 Toxics 11 citations
Article Tier 2

Influence of microplastics on the toxicity of the pharmaceuticals procainamide and doxycycline on the marine microalgae Tetraselmis chuii

Researchers investigated whether the presence of microplastics influences the toxicity of two pharmaceuticals, procainamide and doxycycline, on the marine microalga Tetraselmis chuii. They found that microplastics alone had limited effects, but when combined with pharmaceuticals, the mixture interactions varied depending on the drug and the measured endpoint. The study suggests that the co-occurrence of microplastics and pharmaceutical pollutants in marine environments may produce unpredictable combined effects on primary producers.

2018 Aquatic Toxicology 293 citations
Article Tier 2

Microplastics decrease the toxicity of sulfamethoxazole to marine algae (Skeletonema costatum) at the cellular and molecular levels

Researchers investigated the combined toxicity of the antibiotic sulfamethoxazole and five types of microplastics on the marine alga Skeletonema costatum. They found that certain microplastics actually decreased the toxicity of the antibiotic by adsorbing it, creating a protective "shelter" effect, though polystyrene combined with the antibiotic caused higher oxidative stress. The study suggests that microplastics can alter the bioavailability and toxicity of co-occurring pollutants in marine environments through adsorption interactions.

2022 The Science of The Total Environment 66 citations
Article Tier 2

Combinatory effects of microplastics and emerging contaminants on alga Chlamydomonas reinhardtii

Researchers exposed the green alga Chlamydomonas reinhardtii to two types of microplastics found in face washes — PVC and an acrylate copolymer — along with the preservative 2-phenoxyethanol, finding that combined exposure had distinct effects on algal growth compared to individual pollutants. This is relevant because microplastics rarely occur alone in the environment, and their interactions with other chemicals can either amplify or dampen ecological harm.

2023 Journal of Environmental Engineering and Science 2 citations
Article Tier 2

Nanoplastics and their combined effects with sulphamethoxazole on the free-floating aquatic plant Lemna major

Researchers examined the combined effects of nanoplastics and the antibiotic sulphamethoxazole on free-floating algae, assessing whether nanoplastics alter antibiotic toxicity. The co-exposure produced greater inhibitory effects on algal growth than either substance alone.

2024 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Nanoplastics and their combined effects with sulphamethoxazole on the free-floating aquatic plant Lemna major

Researchers studied the combined effects of polystyrene nanoplastics and the antibiotic sulfamethoxazole on free-floating freshwater organisms, examining how co-exposure to these two pollutants interacts compared to individual exposures. Nanoplastics altered the bioavailability and toxicity of the antibiotic, demonstrating complex mixture effects in aquatic systems.

2024 Zenodo (CERN European Organization for Nuclear Research)
Meta Analysis Tier 1

When antibiotics encounter microplastics in aquatic environments: Interaction, combined toxicity, and risk assessments

A meta-analysis of the combined toxicity of antibiotics and microplastics in aquatic environments found significant adverse effects on algae but limited apparent effects on fish and daphnia. Microplastics alter antibiotic environmental behavior through adsorption and co-transport, and their coexistence is widespread across global aquatic study sites, though standardized risk assessment methods for combined exposure remain lacking.

2024 The Science of The Total Environment 33 citations
Article Tier 2

Toxic effects and mechanisms of nanoplastics and sulfonamide antibiotics on Scenedesmus obliquus

This study tested the combined toxic effects of nanoplastics and sulfonamide antibiotics on freshwater algae, finding that the pollutants together were more harmful than either one alone. The mixture reduced algae growth, damaged cell membranes, and increased oxidative stress. Since algae form the base of aquatic food chains, this damage could cascade through ecosystems and eventually affect the quality of water and food that humans depend on.

2025 Ecotoxicology and Environmental Safety 6 citations
Article Tier 2

Toxicological effects of microplastics and sulfadiazine on Artemia sinica

Researchers exposed the brine shrimp Artemia sinica to the antibiotic sulfadiazine and polystyrene microplastics individually and in combination, finding that all treatments reduced swimming speed and altered antioxidant capacity, with combined exposure producing exacerbated effects.

2025 Environmental Pollution
Article Tier 2

Polystyrene nanoplastics alter the ecotoxicological effects of diclofenac on freshwater microalgae Scenedesmus obliquus

Polystyrene nanoplastics were found to modify the ecotoxicological effects of the pharmaceutical diclofenac on freshwater microalgae Chlamydomonas reinhardtii, with the combined exposure producing effects different from either pollutant alone.

2023 Environmental Science Processes & Impacts 4 citations
Article Tier 2

Influence of polystyrene microplastics on the growth, photosynthetic efficiency and aggregation of freshwater microalgae Chlamydomonas reinhardtii

Polystyrene microplastics at concentrations of 5–100 mg/L inhibited the growth and photosynthetic efficiency of the freshwater microalga Chlamydomonas reinhardtii, and promoted cell aggregation at higher concentrations, with effects scaling with dose.

2020 The Science of The Total Environment 381 citations
Article Tier 2

The combined toxicity influence of microplastics and nonylphenol on microalgae Chlorella pyrenoidosa

Researchers examined the combined toxicity of nonylphenol and several types of microplastics on the freshwater microalgae Chlorella pyrenoidosa. The study found that microplastics of different polymer types and sizes interacted with nonylphenol in complex ways, affecting algal growth, chlorophyll fluorescence, and antioxidant enzyme activity, demonstrating that co-exposure to microplastics and organic pollutants can produce combined toxic effects.

2020 Ecotoxicology and Environmental Safety 252 citations
Article Tier 2

Less toxic combined microplastics exposure towards attached Chlorella sorokiniana in the presence of sulfamethoxazole while massive microalgal nitrous oxide emission under multiple stresses

Researchers studied how microplastics from different plastic types (polyethylene, PVC, and polyamide) interact with an antibiotic in a microalgae-based wastewater treatment system. They found that combining different types of microplastics together was more harmful to the algae than mixing microplastics with the antibiotic. The study also showed that stressed algae released more nitrous oxide, a potent greenhouse gas, meaning microplastic pollution in wastewater could worsen climate change.

2025 Journal of Hazardous Materials 6 citations
Article Tier 2

Unraveling individual and combined toxicity of nano/microplastics and ciprofloxacin to Synechocystis sp. at the cellular and molecular levels

Researchers studied the individual and combined toxic effects of nano- and microplastics with the antibiotic ciprofloxacin on a freshwater cyanobacterium. They found that while each pollutant caused harm on its own, the antibiotic actually showed an antagonistic interaction with the plastic particles, reducing some of their combined toxicity. The study provides important insights into how microplastics and pharmaceutical pollutants interact in aquatic environments, which may complicate pollution risk assessments.

2021 Environment International 105 citations
Article Tier 2

Influence of polystyrene microplastics on levofloxacin removal by microalgae from freshwater aquaculture wastewater

Researchers found that polystyrene microplastics inhibited Chlorella vulgaris growth and reduced its efficiency in removing the antibiotic levofloxacin from freshwater aquaculture wastewater, demonstrating that microplastic pollution can impair microalgae-based water treatment systems.

2021 Journal of Environmental Management 42 citations
Article Tier 2

Size-dependent effect of microplastics on toxicity and fate of diclofenac in two algae

This study investigated how different sizes of polystyrene microplastics affect two species of algae and interact with the common pharmaceutical pollutant diclofenac. Researchers found that the smallest microplastics caused the most significant growth inhibition in algae, and the combined presence of microplastics and diclofenac could alter how each pollutant behaves. The findings underscore how microplastics can change the toxicity and environmental fate of other water contaminants.

2023 Journal of Hazardous Materials 35 citations
Article Tier 2

Single and combined toxicity assessment of primary or UV-aged microplastics and adsorbed organic pollutants on microalga Chlorella pyrenoidosa

Researchers investigated the single and combined toxicity of polyamide microplastics with the pollutants sulfamethoxazole and dicamba on the green alga Chlorella pyrenoidosa. They found that UV-aged microplastics caused different toxic effects than pristine ones, and that microplastics altered the bioavailability and toxicity of the co-occurring pollutants. The study suggests that environmental aging of microplastics changes their interactions with other contaminants, potentially affecting aquatic organisms in complex ways.

2022 Environmental Pollution 45 citations
Article Tier 2

Alleviating effects of microplastics together with tetracycline hydrochloride on the physiological stress of Closterium sp.

Researchers studied how PET and PBT microplastics combined with the antibiotic tetracycline affect freshwater microalgae. They found that in some combinations, microplastics actually reduced the toxicity of the antibiotic to the algae, likely by adsorbing the chemical onto their surfaces. The study highlights the complex and sometimes counterintuitive ways that microplastics interact with other pollutants in aquatic environments.

2024 Environmental Science Processes & Impacts 5 citations
Article Tier 2

Size-specific mediation of the physiological responses and degradation ability of microalgae to sulfamerazine by microplastics

Researchers examined how polystyrene microplastics of different sizes affect the ability of marine microalgae to tolerate and break down the antibiotic sulfamerazine. They found that nano-sized plastics were more harmful than larger particles, reducing algal growth and impairing the organisms' ability to degrade the antibiotic. The study reveals that microplastic pollution could interfere with the natural biological breakdown of pharmaceutical contaminants in waterways.

2025 Aquatic Toxicology 3 citations
Article Tier 2

Interactive toxicity effects of metronidazole, diclofenac, ibuprofen, and differently functionalized nanoplastics on marine algae Chlorella sp.

Researchers examined the combined toxicity of common pharmaceutical drugs and nanoplastics with different surface coatings on marine algae. They found that the interaction between drugs and nanoplastics produced effects ranging from additive to synergistic, depending on the specific combination, with amine-coated nanoplastics generally causing more harm. The study highlights that real-world mixtures of pharmaceutical and plastic pollutants in oceans may pose greater risks to marine life than either contaminant alone.

2025 Environmental Science Processes & Impacts 3 citations
Article Tier 2

Interactive Effects of Ionophore Antibiotic Monensin and Polystyrene Microplastics on the Growth and Physiology of Microcystis aeruginosa

Researchers examined the combined effects of the ionophore antibiotic monensin and polystyrene microplastics on the growth and stress physiology of the cyanobacterium Microcystis aeruginosa under controlled laboratory conditions. The study found interactive effects between the two stressors on algal growth rates and physiological stress markers, suggesting microplastics can modify the ecotoxicological impact of co-occurring pharmaceuticals.

2025 Stresses
Article Tier 2

Combined effects of microplastics and pharmaceutical and personal care products on algae: A critical review

This review examines how microplastics and pharmaceutical or personal care product residues interact when they co-occur in aquatic environments and affect algae. Researchers found that the combined effects can be either antagonistic or synergistic depending on factors like microplastic size, charge, and the type of chemical involved. The study identifies the type of pharmaceutical compound and the species of algae as the most important factors determining whether these pollutant combinations cause greater or lesser harm.

2024 Environmental Pollution 8 citations