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61,005 resultsShowing papers similar to Assessment on intestinal health from polylactic acid microplastics degradation on rare minnow (Gobiocypris rarus): Inflammation regulation by mitochondrial dysfunction
ClearPolylactic acid microplastics and fish species intestinal inflammation risk: Associated with mitochondrial function mediated by Sesn2/Nrf2 pathway
Researchers exposed rare minnow fish to polylactic acid microplastics and found that even low concentrations caused intestinal inflammation and disrupted mitochondrial function. The study identified a specific molecular pathway involving the proteins Sesn2 and Nrf2 that mediated the damage. The findings suggest that microplastics from biodegradable plastics may still pose meaningful risks to the gut health of aquatic organisms.
Long-term exposure to microplastics induces intestinal function dysbiosis in rare minnow (Gobiocypris rarus)
Researchers exposed rare minnow fish to polystyrene microplastics for up to 28 days and found progressive intestinal dysfunction including structural damage, increased oxidative stress enzyme activity, and disruption of gut microbiota. The study suggests that long-term microplastic exposure can cause cumulative intestinal damage, with inflammation and barrier function impairment worsening over extended exposure periods.
Effects of biodegradable and conventional microplastics on the intestine, intestinal community composition, and metabolic levels in tilapia (Oreochromis mossambicus)
Researchers exposed tilapia fish to both biodegradable (PLA) and conventional (PVC) microplastics for 14 days and compared the effects on their intestines and gut bacteria. Both types of microplastics caused intestinal inflammation and disrupted the gut microbial community, though the specific effects differed between the two plastic types. The study suggests that biodegradable microplastics may not be substantially safer for aquatic life than conventional ones.
Photolytic degradation elevated the toxicity of polylactic acid microplastics to developing zebrafish by triggering mitochondrial dysfunction and apoptosis
Researchers found that biodegradable polylactic acid (PLA) microplastics become more toxic to zebrafish after being broken down by sunlight over 90 days. UV exposure shrank the particles and generated nanoplastics, which were harder for the fish to expel from their bodies compared to the original material. The degraded PLA triggered oxidative stress and mitochondrial damage in developing zebrafish, suggesting that the environmental breakdown of biodegradable plastics may actually increase their harmful effects.
Investigating the toxicity of polylactic acid microplastics on the health and physiology of freshwater fish, Cirrhinus mrigala
Researchers fed freshwater fish polylactic acid (PLA) microplastics, often considered a more eco-friendly plastic alternative, for 90 days at various concentrations. They found that PLA microplastics negatively affected the fish's growth, nutrient digestibility, blood chemistry, and caused tissue damage to the liver and intestines. The findings suggest that even biodegradable plastics can be harmful to aquatic organisms when ingested over time.
Microplastics accumulation in gut and revealing their impacts on nutritional quality and health of freshwater carp, Catla catla
Researchers fed common carp (Catla catla) diets containing increasing concentrations of polylactic acid microplastics (PLA-MPs) — a type of biodegradable plastic — for 90 days, finding that at higher levels the fish experienced stunted growth, reduced nutrient absorption, altered blood cell counts, and intestinal tissue damage. The study demonstrates that even "biodegradable" microplastics can accumulate in fish and significantly harm their health.
Plastic food? Energy compensation of zebrafish (Danio rerio) after long-term exposure to polylactic acid biomicroplastics
Zebrafish exposed to biodegradable PLA (polylactic acid) microplastics for 90 days accumulated more plastic in their guts than fish exposed to conventional PET plastic, and suffered more intestinal damage. Although the fish partially compensated by using the PLA breakdown products for energy, the study shows that bio-based plastics still carry meaningful ecological risks for aquatic organisms that can enter our food chain.
Polylactic Acid-Based Microplastic Particles Induced Oxidative Damage in Brain and Gills of Goldfish Carassius auratus
Researchers exposed goldfish to particles from biodegradable polylactic acid cups and shopping bags, as well as conventional polyamide plastic, for 96 hours. They found that the PLA cup particles caused significant oxidative damage in the fish's brain and gill tissues, while the bag and conventional plastic particles did not. The study raises important questions about whether bioplastic alternatives may pose their own environmental risks to aquatic life.
Potential toxic effects of polylactic acid microplastics accumulation on multiple tissue structures and hematology in carp
Researchers exposed common carp to polylactic acid microplastics over an extended period and assessed effects on multiple tissue types and blood parameters. PLA-MP accumulation caused histological damage in gills, liver, and intestine, and altered hematological markers, demonstrating that biodegradable plastics are not toxicologically inert to fish.
Mechanisms underlying mitochondrial dysfunction and intestinal damage induced by ingestion of microplastics in Leuciscus waleckii: The role of the NF-κB/Nrf2 signaling pathway
This study found that polystyrene microplastics harmed juvenile fish by triggering immune dysfunction, oxidative stress, and mitochondrial damage in their intestines. The microplastics activated inflammatory pathways, damaged the intestinal barrier, and shifted the gut microbiome toward harmful bacteria. These findings suggest that microplastic ingestion could have cascading effects on fish health through multiple biological pathways.
Comparative toxicity of virgin and biodegraded LLDPE microplastics on growth, behavior, antioxidant, and hematological health of Catla catla fish
Researchers compared the toxicity of virgin versus bacterially degraded polyethylene microplastics on freshwater fish, finding that both types caused abnormal behaviors and disrupted blood parameters in a dose-dependent manner. However, biodegraded microplastics produced less severe effects on growth, survival, and antioxidant enzyme activity, suggesting that microbial degradation may reduce the ecological risk posed by microplastic pollution.
Aged polylactic acid microplastics exacerbate lipid metabolism disorders and cardiac dysfunction via PPARγ activation in zebrafish: A comparative study with polymers and oligomers
Researchers compared the toxicity of polylactic acid microplastics at different degradation stages—polymers, oligomers, and aged polymers—in zebrafish larvae, finding that aged PLA most severely disrupted lipid metabolism and cardiac function through PPARγ activation.
Stressful Effects of Individual and Combined Exposure to Low-Concentration Polylactic Acid Microplastics and Chromium on Marine Medaka Larvae (Oryzias melastigma)
Researchers exposed marine medaka fish larvae to low concentrations of biodegradable polylactic acid microplastics and chromium, both individually and together, for 14 days. The combined exposure caused more severe intestinal damage, oxidative stress, and disruption of gut bacteria than either pollutant alone. The study suggests that even biodegradable microplastics can worsen the effects of heavy metal pollution on young fish in marine environments.
Polylactic acid microplastics before and after aging induced neurotoxicity in zebrafish by disrupting the microbiota-gut-brain axis
Researchers exposed zebrafish to microplastics made from PLA, a common biodegradable plastic, and found that both new and aged PLA particles caused brain and nerve damage, including sluggish behavior, memory problems, and increased aggression. Aged PLA particles were even more toxic, and the damage appeared to work through disruption of the gut-brain connection, raising concerns about the safety of biodegradable plastics as they break down in water.
Effects of MP Polyethylene Microparticles on Microbiome and Inflammatory Response of Larval Zebrafish
Zebrafish larvae exposed to polyethylene microplastics for up to 10 days showed no broad metabolic disturbances or inflammatory changes, but oxidative stress markers increased at 15 days and the gut microbiome was disrupted, with higher levels of bacteria linked to intestinal disease. The findings suggest microplastics alter the microbial environment of fish guts without triggering obvious inflammation.
Nanoplastics impair the intestinal health of the juvenile large yellow croaker Larimichthys crocea
Researchers exposed juvenile large yellow croaker fish to nano-sized polystyrene particles to assess impacts on intestinal health and growth. The study found that nanoplastics accumulated in the fish and caused disorders in digestion, antioxidant defenses, immune function, and intestinal microflora, indicating that nanoplastics can significantly impair gut health in commercially important marine fish species.
Different effects of nano- and microplastics on oxidative status and gut microbiota in the marine medaka Oryzias melastigma
Researchers compared the effects of nanoplastics and microplastics on oxidative stress and gut microbiota in marine medaka fish. They found that nanoplastics caused more severe oxidative damage and greater disruption to the gut microbial community than larger microplastic particles. The study suggests that particle size plays a critical role in determining the biological impact of plastic pollution on aquatic organisms.
Multiple endpoints of polylactic acid biomicroplastic toxicity in adult zebrafish (Danio rerio)
Researchers exposed adult zebrafish to polylactic acid (PLA) bioplastic microparticles for 30 days and found accumulation in liver, brain, gills, and tissue, along with social behavior disruption, cholinergic changes, oxidative imbalance, and altered pigmentation — challenging the assumption that biodegradable bioplastics are environmentally benign.
Impacts of conventional and biodegradable microplastics on juvenile Lates calcarifer: Bioaccumulation, antioxidant response, microbiome, and proteome alteration
Researchers found that both conventional polyethylene and biodegradable microplastics from plastic bags caused bioaccumulation, oxidative stress, microbiome disruption, and proteome alterations in juvenile barramundi, indicating that biodegradable plastics are not necessarily safer for marine organisms.
Deleterious Effects of Polypropylene Microplastic Ingestion in Nile Tilapia (Oreochromis niloticus)
Researchers fed Nile tilapia daily doses of polypropylene microplastics for 30 days and observed significant health effects including changes in blood cell counts, altered gut bacteria, and tissue damage to the intestines and liver. The higher dose group showed more pronounced effects, including elevated inflammatory markers and signs of oxidative stress. The study provides evidence that chronic ingestion of microplastics commonly found in aquatic environments can cause meaningful harm to a widely consumed fish species.
Chronic exposure to low concentrations of microplastics causing gut tissue damage but non-significant changes in the microbiota of marine medaka larvae (Oryzias melastigma)
Marine medaka fish larvae exposed to low concentrations of polyethylene and polylactic acid microplastics for 60 days showed no changes in growth or survival, but their intestinal tissue was visibly damaged with inflammation and loss of gut lining. The gut microbiome remained largely intact despite the physical tissue damage. This study suggests that microplastics can cause hidden gut injury even at low levels that do not affect outward signs of health, raising concerns about subtle damage going undetected.
Polylactic Acid Microplastics Do Not Exhibit Lower Biological Toxicity in Growing Mice Compared to Polyvinyl Chloride Microplastics
Researchers compared the health effects of biodegradable polylactic acid microplastics to conventional polyvinyl chloride microplastics in growing mice over six weeks. Contrary to expectations, the biodegradable microplastics caused equal or more severe harm, including greater disruption of gut bacteria, stronger inflammatory responses, and more intestinal damage. The study suggests that biodegradable plastics may not be safer than conventional plastics once they break down into microplastic-sized particles.
Microplastics induce intestinal inflammation, oxidative stress, and disorders of metabolome and microbiome in zebrafish
Researchers exposed zebrafish to polystyrene microplastics for 21 days and found significant intestinal inflammation, oxidative stress, and disruption of both the gut microbiome and metabolic processes. The microplastics altered the balance of beneficial and harmful gut bacteria and changed the levels of key metabolites involved in energy and amino acid metabolism. The study provides detailed evidence that microplastic ingestion can cause widespread disruption to gut health in aquatic organisms.
Microplastics induce toxic effects in fish: Bioaccumulation, hematological parameters and antioxidant responses
Researchers exposed juvenile fish to polyamide microplastics and found the particles accumulated primarily in the intestine, gills, and liver, causing reduced blood oxygen-carrying capacity, liver stress, and disrupted antioxidant defenses. These findings matter because fish are an important food source for humans, and microplastic accumulation in fish tissues could transfer these contaminants to people through their diet.