Papers

61,005 results
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Article Tier 2

Contrasting effects of micro- and nanoplastics on accumulation and toxicity of tris(1,3-dichloro-2-propyl) phosphate in zebrafish embryo revealed by toxicokinetic-toxicodynamic model

Researchers examined how microplastics and nanoplastics differently affect the accumulation and toxicity of the flame retardant TDCIPP in zebrafish embryos. The study found that while microplastics had minimal effect, nanoplastics significantly increased TDCIPP bioaccumulation and enhanced adverse effects on hatching, development, and survival, as validated by toxicokinetic and toxicodynamic modeling.

2026 Environmental Toxicology and Chemistry
Article Tier 2

Parental transfer of nanopolystyrene-enhanced tris(1,3-dichloro-2-propyl) phosphate induces transgenerational thyroid disruption in zebrafish

Researchers investigated the transgenerational effects of nanoplastics combined with the flame retardant TDCIPP on zebrafish thyroid function. The study found that nanopolystyrene enhanced the bioavailability and toxicity of TDCIPP, and that parental exposure induced thyroid disruption that was passed to offspring, suggesting that nanoplastics may amplify the harmful effects of co-occurring pollutants across generations.

2021 Aquatic Toxicology 60 citations
Article Tier 2

Further negative effect of fibrous microplastics to the bioaccumulation and toxicity of decabromodiphenyl ethane on zebrafish

Researchers investigated how fibrous microplastics from PET plastic interact with a common flame retardant chemical called DBDPE in zebrafish over 28 days. They found that microplastics significantly increased the amount of the flame retardant that accumulated in fish tissue and slowed its elimination from the body. The study suggests that microplastics may act as carriers for other toxic chemicals, amplifying their harmful effects on aquatic organisms.

2025 The Science of The Total Environment 3 citations
Article Tier 2

Nanoplastics aggravated TDCIPP-induced transgenerational developmental neurotoxicity in zebrafish depending on the involvement of the dopamine signaling pathway

Zebrafish exposed to nanoplastics combined with TDCIPP (a common flame retardant chemical) from embryo to adulthood showed more severe brain development problems than exposure to either pollutant alone. The nanoplastics increased the absorption of the flame retardant and together they disrupted the dopamine signaling pathway in the brain, with toxic effects carrying over to the next generation. This highlights how nanoplastics can amplify the neurotoxicity of other environmental chemicals.

2024 Environmental Toxicology and Pharmacology 25 citations
Article Tier 2

Polymer aging affects the bioavailability of microplastics-associated contaminants in sea urchin embryos

Researchers found that UV aging of microplastics alters the bioavailability of co-contaminants like flame retardants and metals to sea urchin embryos, with combined exposures generating transcriptional responses distinct from single-contaminant effects.

2022 Chemosphere 22 citations
Article Tier 2

Comparative impact of pristine and aged microplastics with triclosan on lipid metabolism in larval zebrafish: Unveiling the regulatory role of miR-217

Scientists found that when microplastics and the antimicrobial chemical triclosan coexist in water, microplastics increase the amount of triclosan that accumulates in zebrafish larvae, disrupting fat metabolism through a specific genetic pathway. Aged microplastics, which have weathered surfaces, actually carried less triclosan and caused less harm than fresh microplastics. This research shows how microplastics can amplify the toxic effects of common household chemicals in aquatic organisms that are part of the food chain.

2024 The Science of The Total Environment 15 citations
Article Tier 2

Adsorption behaviors and bioavailability of tetrabromobisphenol A in the presence of polystyrene microplastic in soil: Effect of microplastics aging

Researchers studied how aging changes the ability of polystyrene microplastics to absorb and release a flame retardant chemical called TBBPA in soil. They found that aged microplastics had a greater capacity to adsorb the chemical but also released it more readily, increasing the bioavailability of this toxic compound to soil organisms. The study reveals that as microplastics weather in the environment, they may actually become more effective carriers of harmful chemicals into the food chain.

2023 Environmental Pollution 73 citations
Article Tier 2

Effects of pristine or contaminated polyethylene microplastics on zebrafish development

Researchers examined the effects of both pristine and pollutant-contaminated polyethylene microplastics on zebrafish development through chronic exposure. The study assessed how microplastics, both alone and as carriers of adsorbed organic pollutants, affect developing fish. The findings provide new insights into how contaminated microplastics may create additional routes for toxic compounds to enter aquatic food webs.

2022 Chemosphere 66 citations
Article Tier 2

[Sorption of Polybrominated Diphenyl Ethers by Virgin and Aged Microplastics].

This study examined how environmental aging under UV light changes the ability of polyethylene and polystyrene microplastics to adsorb polybrominated diphenyl ethers (PBDEs), common flame retardant chemicals. Aged microplastics showed altered sorption capacity compared to virgin particles, affecting how these toxic chemicals are transported in aquatic environments.

2020 PubMed 12 citations
Article Tier 2

Influence of ultraviolet-aging and adsorbed pollutants on toxicological effects of polyvinyl chloride microplastics to zebrafish

Researchers studied how UV aging changes polyvinyl chloride microplastics and their toxicity to zebrafish, both alone and when carrying adsorbed pollutants. They found that aged microplastics caused more severe gut damage and oxidative stress than pristine particles, due to increased free radicals on their surfaces. When carrying adsorbed chlorpyrifos or erythromycin, the microplastics served as pollutant carriers into fish, producing greater behavioral disruption and gut microbiome alterations.

2022 Environmental Pollution 69 citations
Article Tier 2

Effects of fibrous microplastics on the accumulation of tris(2,3-dibromopropyl) isocyanurate and behavior of zebrafish via water- and foodborne exposure routes

Researchers found that fibrous microplastics enhanced the accumulation of the flame retardant tris(2,3-dibromopropyl) isocyanurate in zebrafish and altered their swimming behavior, demonstrating how MP shape influences contaminant uptake and neurotoxicity.

2023 The Science of The Total Environment 11 citations
Article Tier 2

Potential effects of natural aging process on the characteristics and toxicity of facial masks: A zebrafish-based study

Researchers found that naturally aged facial mask microplastics caused greater toxicity in zebrafish than virgin fragments, inducing more severe oxidative stress, immune responses, and intestinal damage due to surface cracking and chemical adsorption during aging.

2023 Journal of Hazardous Materials 13 citations
Article Tier 2

Enhanced adsorption of tetrabromobisphenol a (TBBPA) on cosmetic-derived plastic microbeads and combined effects on zebrafish

Scientists investigated how cosmetic microbeads adsorb the flame retardant TBBPA and then tested the combined effect on zebrafish, finding that microbeads enhanced TBBPA bioavailability and caused greater developmental toxicity and endocrine disruption than TBBPA exposure alone.

2020 Chemosphere 75 citations
Article Tier 2

Interactive effects of microplastics and selected pharmaceuticals on red tilapia: Role of microplastic aging

Researchers compared how aged versus virgin polystyrene microplastics interact with the antibiotic sulfamethoxazole and the beta-blocker propranolol in red tilapia. They found that aged microplastics, which have rougher surfaces from UV weathering, adsorbed more pharmaceuticals and altered their bioavailability to the fish. The study demonstrates that environmental aging of microplastics changes their capacity to carry and release pharmaceutical contaminants in aquatic systems.

2020 The Science of The Total Environment 135 citations
Article Tier 2

The significance of trophic transfer of microplastics in the accumulation of plastic additives in fish: An experimental study using brominated flame retardants and UV stabilizers

Researchers found that trophic transfer through food is a more significant route than direct water exposure for fish accumulation of plastic-derived chemicals, including brominated flame retardants and UV stabilizers associated with microplastics.

2022 Marine Pollution Bulletin 22 citations
Article Tier 2

Photoaging enhanced the adverse effects of polyamide microplastics on the growth, intestinal health, and lipid absorption in developing zebrafish

Researchers found that polyamide microplastics became significantly more harmful to developing zebrafish after being aged by simulated sunlight, shrinking in size and generating nanoplastic fragments. The aged particles caused greater damage to intestinal health, impaired lipid absorption, and stunted growth compared to unaged microplastics. The study demonstrates that environmental weathering can substantially increase the biological risks posed by microplastics in aquatic ecosystems.

2021 Environment International 133 citations
Article Tier 2

Study on the Adsorption Behavior and Mechanism of Heavy Metals in Aquatic Environment before and after the Aging of Typical Microplastics

Researchers investigated the adsorption behavior and mechanisms of heavy metals by typical microplastics before and after environmental aging, finding that aging significantly alters microplastics' surface properties and capacity to bind metals such as cadmium and lead in aquatic systems.

2024
Article Tier 2

Aging characteristics of polylatic acid microplastics and their adsorption on hydrophilic organic pollutants: mechanistic investigations and theoretical calculations

Researchers characterized how polylactic acid microplastics undergo UV and thermal aging in aquatic environments, finding that aging altered surface chemistry, increased hydrophilicity, and enhanced adsorption of heavy metal pollutants—raising concerns about aged biodegradable plastics as carriers of co-contaminants.

2025 Environmental Pollution 4 citations
Article Tier 2

Aged microplastics-induced growth inhibition via DNA damage, GH/IGF-1 and HPT axes disruption in zebrafish larvae

Researchers compared the developmental effects of pristine versus sunlight-aged polystyrene microplastics on zebrafish embryos at environmentally relevant concentrations. They found that aged microplastics were more toxic than pristine ones, causing greater growth inhibition, DNA damage, and disruption of hormonal pathways involved in growth and thyroid function. The study suggests that as microplastics weather in the environment, they may become increasingly harmful to developing aquatic organisms.

2025 The Science of The Total Environment 3 citations
Article Tier 2

Sorbed environmental contaminants increase the harmful effects of microplastics in adult zebrafish, Danio rerio

Researchers found that microplastics carrying sorbed environmental contaminants (DDE, BP-3, chlorpyrifos) caused greater harmful effects on adult zebrafish health and behavior than pristine microplastics alone, demonstrating their role as pollutant vectors.

2023 Aquatic Toxicology 14 citations
Article Tier 2

The influence of different polymer types of microplastics on adsorption, accumulation, and toxicity of triclosan in zebrafish

Researchers investigated how different polymer types of microplastics affect the toxicity and bioaccumulation of the antimicrobial chemical triclosan in zebrafish. They found that polypropylene microplastics had the highest capacity to adsorb triclosan and that co-exposure significantly worsened oxidative stress, lipid damage, and neurotoxicity compared to triclosan alone. The study demonstrates that the type of microplastic polymer matters when assessing the combined environmental risks of plastics and chemical pollutants.

2020 Journal of Hazardous Materials 162 citations
Article Tier 2

Leaching of polybrominated diphenyl ethers from microplastics in fish oil: Kinetics and bioaccumulation

The leaching kinetics of polybrominated diphenyl ethers (PBDEs) from microplastics into fish oil were characterized to estimate chemical transfer to organism tissues upon ingestion. Leaching rates were contaminant- and polymer-dependent, providing mechanistic data for assessing how ingested microplastics increase exposure to inherent flame retardant additives.

2020 Journal of Hazardous Materials 52 citations
Article Tier 2

Enhanced toxicity of triphenyl phosphate to zebrafish in the presence of micro- and nano-plastics

Co-exposure of zebrafish to triphenyl phosphate (TPhP) with micro- or nano-polystyrene showed that nano-PS (46 nm) aggravated TPhP-induced liver and gonad enlargement, while micro-PS had minimal effect — suggesting nanoplastics can enhance the toxicity of organophosphate flame retardants.

2020 The Science of The Total Environment 81 citations
Article Tier 2

Influence of microplastics on bisphenol A and bisphenol AF toxicity in aquatic environments: Mechanistic insights for environmental risks

Researchers investigated how polyethylene microplastics interact with the industrial chemicals bisphenol A and bisphenol AF in zebrafish, finding that microplastics can either reduce or worsen the toxicity depending on the specific chemical and biological pathway involved. For bisphenol A, the microplastics partially absorbed the chemical and reduced its harmful effects, but for bisphenol AF, they worsened toxicity to certain organ systems. The study reveals that microplastics play a complicated dual role in modifying how other pollutants affect aquatic life.

2025 Journal of Hazardous Materials 4 citations