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61,005 resultsShowing papers similar to Impact of polystyrene microplastic exposure on lipid profile and oxidative stress status of male and female Wistar rats
ClearReproductive and metabolic toxic effects of polystyrene microplastics in adult female Wistar rats: a mechanistic study
Researchers gave female rats polystyrene microplastics orally for 45 days and found disruptions to both metabolic and reproductive hormone levels, including increased cholesterol, insulin resistance, and altered sex hormones. The microplastics also caused liver fibrosis and elevated inflammatory markers. The study suggests that chronic microplastic exposure may contribute to metabolic and endocrine disruption in mammals.
Impact of polystyrene microplastic exposure at low doses on male fertility: an experimental study in rats
Researchers exposed adult male rats to varying doses of polystyrene microplastics and found dose-dependent declines in semen quality along with disrupted reproductive hormone levels. Higher doses caused increased oxidative stress, mitochondrial damage, and inflammatory responses in testicular tissue. The study suggests that even relatively low doses of microplastic exposure may have adverse effects on male reproductive health in animal models.
Polystyrene Microplastics Disrupt Spermatogenesis through Oxidative Stress in Rat Testicular Tissue
Male Wistar rats orally administered polystyrene microplastics showed excessive oxidative stress in testicular tissue across all exposure groups, with spermatogenesis impairment and reduced fertility correlating with dose, demonstrating reproductive toxicity in a mammalian model.
Assessment of the Accumulation and Potential Toxicity of Polystyrene Microplastics in Rats
This study assessed polystyrene microplastic accumulation in aquatic organisms and evaluated associated toxicity endpoints including oxidative stress, histological changes, and behavioral effects. Microplastics accumulated in multiple tissues and caused dose-dependent physiological harm.
Impact of Polystyrene Exposure on Hepatorenal Responses in Male and Female Albino Wistar Rats
This study examined the impact of polystyrene microplastic exposure on kidney and liver function in male and female albino rats, finding sex-dependent differences in organ pathology and biomarker responses after subchronic exposure.
Dose-Dependent Effect of Polystyrene Microplastics on the Testicular Tissues of the Male Sprague Dawley Rats
Male rats exposed to increasing doses of polystyrene microplastics showed dose-dependent testicular damage including disrupted spermatogenesis and altered hormone levels, suggesting potential reproductive toxicity from microplastic accumulation.
The cardiovascular toxicity of polystyrene microplastics in rats: based on untargeted metabolomics analysis
A rat study using metabolomics analysis found that long-term exposure to high concentrations of polystyrene microplastics led to abnormal fat metabolism and cardiovascular damage. The harm appeared to be driven by oxidative stress and inflammation, suggesting that chronic microplastic exposure could contribute to heart and blood vessel disease.
Gender difference in hepatic AMPK pathway activated lipid metabolism induced by aged polystyrene microplastics exposure
Researchers found gender-specific effects of aged polystyrene microplastics on lipid metabolism in mice, with females showing significant fat reduction and altered estrogen-AMPK signaling pathways in the liver, while males showed different metabolic responses.
Thyroid endocrine status and biochemical stress responses in adult male Wistar rats chronically exposed to pristine polystyrene nanoplastics
Adult male rats were given daily oral doses of polystyrene nanoplastics for five weeks, causing dose-dependent reductions in thyroid hormone levels (T3, T4, FT3, FT4) and increases in TSH, along with elevated oxidative stress markers. The study provides evidence that chronic nanoplastic ingestion disrupts the thyroid endocrine system in a mammalian model.
Chronic toxic effects of polystyrene microplastics on reproductive parameters of male rats
Researchers studied the chronic toxic effects of polystyrene microplastics on the reproductive system of male rats over 90 days. The study found significant reductions in sperm volume, motility, epididymal count, and serum testosterone levels, along with disrupted testicular architecture and decreased antioxidant capacity. The findings suggest that chronic microplastic exposure may adversely affect male reproductive parameters in mammals.
Polystyrene microplastics cause granulosa cells apoptosis and fibrosis in ovary through oxidative stress in rats
Researchers exposed female rats to polystyrene microplastics at different concentrations for 90 days and examined the effects on their ovaries. The study found that microplastic exposure caused cell death and tissue scarring in the ovaries through oxidative stress, suggesting that microplastics may have implications for female reproductive health.
Dose‐Dependent Toxicological Effects of Polyvinyl Chloride and Polystyrene Microplastics on Wistar Albino Rats
Researchers fed rats PVC and polystyrene microplastics at different doses for eight weeks and observed significant changes including weight loss, elevated blood glucose, increased cholesterol and liver enzymes, and signs of oxidative stress. The study suggests that oral microplastic exposure at these levels can cause dose-dependent toxicological effects across multiple organ systems in mammals.
Comparative analysis of reproductive toxicity of polystyrene‐nanoplastics and polystyrene‐microplastics in rat Sertoli cells
This comparative study found that polystyrene nanoplastics cause greater toxicity to Sertoli cells than microplastics due to cellular internalization, disrupting blood-testis barrier integrity via oxidative stress and apoptosis, while microplastics primarily triggered extracellular inflammation.
Comparative impact of polystyrene, rice bag-derived high-density polyethylene nanoparticles, and polystyrene–silver nanoparticle interactions in a 28-day in vivo study in male and female Wistar rats
Researchers gave rats daily doses of plastic nanoparticles for 28 days and found subtle signs of DNA damage, cholesterol changes, and liver stress — with females showing greater sensitivity in lipid metabolism and males experiencing reduced testicular weight from HDPE plastic nanoparticles. The study highlights that the health effects of nanoplastics differ by sex and can be worsened when multiple types of nanoparticles are mixed together.
The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge
Researchers administered polystyrene nanoplastics orally to male rats for five weeks and found significant reductions in testosterone, LH, and FSH levels, sperm DNA damage, altered testicular gene expression, and dose-dependent histological lesions, indicating that nanoplastic exposure disrupts the hormonal axis governing male reproductive function.
Untargeted lipidomics uncover hepatic lipid signatures induced by long-term exposure to polystyrene microplastics in vivo
Researchers exposed rats to polystyrene microplastics over 6 and 12 months and used advanced lipid profiling to assess liver damage. They found that long-term exposure caused liver inflammation, fatty liver changes, and significant alterations in eight key lipid metabolites involved in fat processing. The study provides evidence that chronic microplastic exposure can disrupt liver lipid metabolism, raising concerns about long-term health effects.
Can Mammalian Reproductive Health Withstand Massive Exposure to Polystyrene Micro- and Nanoplastic Derivatives? A Systematic Review
This systematic review examined how polystyrene micro- and nanoplastics affect reproductive health in mammals. The evidence from animal studies shows these particles can cause oxidative stress, inflammation, and hormonal imbalances in reproductive organs, raising concerns about potential effects on human fertility.
Nanoplastics-induced oxidative stress, antioxidant defense, and physiological response in exposed Wistar albino rats
Researchers orally exposed Wistar rats to polystyrene nanoplastics at multiple doses for five weeks and observed dose-dependent increases in oxidative stress. The study found significant alterations in liver and kidney function markers, disrupted energy metabolism, and changes in antioxidant enzyme activity, suggesting that nanoplastic exposure may affect multiple organ systems in mammals.
Reproductive Toxicity of Chronic Exposure To Polystyrene Microplastics And The Molecular Mechanism of Decrease In Testosterone Levels In Male Mice
Chronic exposure to polystyrene microplastics lowered testosterone levels in male mice and disrupted reproductive organ function. The study identified molecular pathways through which microplastics interfere with male hormone production, with implications for reproductive health in humans exposed through diet.
Dose-dependent alteration in hepatic and cerebral glucose metabolism following exposure to polystyrene microplastic in Wistar rats
Researchers exposed Wistar rats to polystyrene microplastics and observed dose-dependent changes in glucose metabolism in both the liver and brain. The study suggests that microplastic exposure may disrupt normal metabolic processes, with higher doses leading to more pronounced alterations in hepatic and cerebral glucose handling.
Polystyrene Microplastics Affect the Reproductive Performance of Male Mice and Lipid Homeostasis in Their Offspring
Researchers found that long-term exposure to environmentally relevant doses of polystyrene microplastics over 21 weeks significantly impaired reproductive function in male mice, including decreased testicle weight and sperm quality. The study also revealed transgenerational effects, with offspring showing disrupted lipid homeostasis.
Toxic Effects of Immunofluorescent Polystyrene Nanoplastics on Rat Testicular Tissue
Researchers exposed rat testicular tissue to fluorescent polystyrene nanoplastics at two different doses for one month and found that the particles accumulated in the reproductive organs. Higher doses led to increased oxidative stress, tissue damage, and changes in biochemical markers associated with reproductive function. The study suggests that nanoplastic exposure may pose risks to male reproductive health, though more research is needed to understand the implications for humans.
Polystyrene nanoplastics dysregulate lipid metabolism in murine macrophages in vitro
Researchers investigated the effects of polystyrene nanoplastics on immune cell metabolism and found that macrophages exposed to nanoplastics transformed into lipid-laden foam cells. The study suggests that nanoplastic exposure dysregulates lipid metabolism in immune cells, with implications for understanding how these particles may interact with the immune system at the cellular level.
Comparing the effects of polystyrene microplastics exposure on reproduction and fertility in male and female mice
Researchers exposed both male and female mice to polystyrene microplastics for 30 to 44 days and found that the particles accumulated more in ovaries than testes, causing oxidative stress and reproductive damage in both sexes. Male mice had fewer viable sperm and more deformed sperm, while female mice had smaller ovaries with fewer eggs, and both sexes showed altered hormone levels and reduced fertility. This study suggests that microplastic exposure could contribute to declining fertility in both men and women.