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Assessment of the Accumulation and Potential Toxicity of Polystyrene Microplastics in Rats

Journal of Hazardous Toxic and Radioactive Waste 2024 Score: 45 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Tooraj Massahi, Tooraj Massahi, Meghdad Pirsaheb, Monireh Nouri, Hooshyar Hossini, Hooshyar Hossini, Tooraj Massahi, Tooraj Massahi, Monireh Nouri, Pouran Makhdoumi Pouran Makhdoumi Pouran Makhdoumi Pouran Makhdoumi Pouran Makhdoumi Pouran Makhdoumi Meghdad Pirsaheb, Meghdad Pirsaheb, Meghdad Pirsaheb, Monireh Nouri, Tooraj Massahi, Tooraj Massahi, Tooraj Massahi, Tooraj Massahi, Hooshyar Hossini, Hooshyar Hossini, Hooshyar Hossini, Hooshyar Hossini, Hooshyar Hossini, Hooshyar Hossini, Hooshyar Hossini, Hooshyar Hossini, Monireh Nouri, Meghdad Pirsaheb, Meghdad Pirsaheb, Pouran Makhdoumi Pouran Makhdoumi Pouran Makhdoumi Pouran Makhdoumi Ronak Abdulazeez Meshabaz, Abdulfattah A. Amin, Ronak Abdulazeez Meshabaz, Abdulfattah A. Amin, Ronak Abdulazeez Meshabaz, Meghdad Pirsaheb, Hooshyar Hossini, Meghdad Pirsaheb, Hooshyar Hossini, Meghdad Pirsaheb, Pouran Makhdoumi Meghdad Pirsaheb, Pouran Makhdoumi Tooraj Massahi, Ronak Abdulazeez Meshabaz, Abdulfattah A. Amin, Abdulfattah A. Amin, Meghdad Pirsaheb, Meghdad Pirsaheb, Monireh Nouri, Tooraj Massahi, Monireh Nouri, Tooraj Massahi, Hooshyar Hossini, Hooshyar Hossini, Tooraj Massahi, Pouran Makhdoumi Hooshyar Hossini, Meghdad Pirsaheb, Meghdad Pirsaheb, Monireh Nouri, Meghdad Pirsaheb, Hooshyar Hossini, Hooshyar Hossini, Monireh Nouri, Meghdad Pirsaheb, Meghdad Pirsaheb, Meghdad Pirsaheb, Hooshyar Hossini, Hooshyar Hossini, Meghdad Pirsaheb, Hooshyar Hossini, Pouran Makhdoumi Tooraj Massahi, Hooshyar Hossini, Pouran Makhdoumi Mahnaz Ahmadimanesh, Mohammad Reza Zirak, Meghdad Pirsaheb, Monireh Nouri, Samane Danaei, Samane Danaei, Tooraj Massahi, Hooshyar Hossini, Mojtaba Limoee, Mojtaba Limoee, Ronak Abdulazeez Meshabaz, Monireh Nouri, Ronak Abdulazeez Meshabaz, Hooshyar Hossini, Somayeh Mohammadi, Meghdad Pirsaheb, Hooshyar Hossini, Pouran Makhdoumi

Summary

This study assessed polystyrene microplastic accumulation in aquatic organisms and evaluated associated toxicity endpoints including oxidative stress, histological changes, and behavioral effects. Microplastics accumulated in multiple tissues and caused dose-dependent physiological harm.

Polymers

Body Systems

Digestive Hepatic Renal

Models

Rat

In recent years, there has been a significant amount of research conducted on microplastics (MPs) as emerging pollutants. These particles, which are < 5 mm in size, are the primary cause of environmental and aquatic contamination. Due to the high exposure to MPs and insufficient information available on their toxicity to humans and animals, it is important to prioritize and assess the risks associated with MPs. This study aimed to investigate the effects of exposure to polystyrene (PS)-MPs on Wistar rats. Following an acclimatization period, 120 rats with an average weight of 190 ± 10 g were randomly allocated into 24 cages a week before the commencement of the experiment. Over varying durations ranging from 1 to 28 days, the rats were exposed to PS-MPs at low (0.5 mg) and high (0.1 mg) doses. Additionally, a control group received corn oil without MPs. The digested tissue samples were observed under a fluorescence microscope, which revealed the presence of small pieces of MPs in the form of fibers, due to environmental pollution. The liver, kidneys, and colon tissues were histopathologically analyzed, and biomarkers of toxicity were measured in the rats' blood. The results of the animal study indicated that PS-MPs were minimally toxic, and there was no tissue damage in the rats. However, some minor signs were found in biochemical biomarkers. Therefore, further research is necessary to fully understand the potential risks associated with exposure to MPs.

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