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61,005 resultsShowing papers similar to Amine-modified nanoplastics promote the procoagulant activation of isolated human red blood cells and thrombus formation in rats
ClearPB1065 Microvesicles Display Opposite Coagulolytic Balances According to Their Cellular Origin and Activation Status
Polystyrene microplastics activated human vascular endothelial cells, upregulating inflammation markers ICAM-1 and VCAM-1, and promoted larger and denser blood clot formation when added to whole blood perfused over collagen at concentrations found in human plasma. These results raise concern that microplastics circulating in human blood could increase the risk of thrombosis and cardiovascular events.
Nanoplastic-induced vascular endothelial injury and coagulation dysfunction in mice
Researchers exposed mice to polystyrene nanoplastics with different surface modifications and found that the particles caused structural damage to vascular endothelial cells and triggered inflammatory responses. The nanoplastics also disrupted blood coagulation function in the mice. The study suggests that nanoplastic exposure may pose risks to cardiovascular health due to the particles' ability to travel through the bloodstream and damage blood vessel linings.
Interaction of polystyrene nanoplastics with human fibrinogen
Researchers found that polystyrene nanoplastics with different surface modifications disrupted the structure of human fibrinogen, a key blood clotting protein, in a dose-dependent manner. The study suggests that nanoplastics entering the bloodstream could interfere with protein function, raising concerns about the potential biological consequences of nanoplastic exposure in humans.
Polystyrene nanoplastics enhance thrombosis through adsorption of plasma proteins
Researchers found that polystyrene nanoplastics can enter the bloodstream and increase the risk of blood clots by adsorbing key clotting proteins, particularly coagulation factor XII and plasminogen activator inhibitor-1. This protein-adsorption mechanism was confirmed through multiple analytical approaches. The discovery of this thrombosis-promoting pathway is concerning because it suggests that nanoplastic exposure could increase cardiovascular risks like stroke and heart attack.
Amino-modified polystyrene nanoplastics induce endothelial pyroptosis and pro-atherogenic cellular responses
Researchers found that amino-modified polystyrene nanoplastics, particularly 20-nanometer particles, triggered pyroptosis, a form of inflammatory cell death, in human blood vessel endothelial cells. This cell damage promoted the recruitment, adhesion, and lipid accumulation of immune cells, mimicking early stages of atherosclerosis development. The study suggests that surface chemical modifications of nanoplastics can significantly influence their toxicity to the cardiovascular system.
Microplastic Effects on Thrombin-Fibrinogen Clotting Dynamics Measured via Turbidity
Researchers found that non-modified polystyrene microplastics significantly slowed fibrin clot formation in a laboratory model — reducing clotting rate up to 27-fold — while aminated polystyrene had minimal effect, suggesting microplastic surface chemistry may influence blood coagulation dynamics.
Circulating Microplastics as Acute Triggers of Platelet Activation and Coagulation: Implications for Cardiovascular Risk
Researchers exposed human platelets to nanoplastics and found direct activation of platelet aggregation and coagulation pathways at environmentally relevant concentrations. The results suggest that circulating microplastics and nanoplastics could act as acute triggers of thrombosis, with implications for cardiovascular disease risk.
Exploring microplastic impact on whole blood clotting dynamics utilizing thromboelastography
Researchers used a blood clotting analysis technique to study how polystyrene microplastics of different sizes and surface types affect human blood clotting. They found that negatively charged particles consistently activated the clotting process, increasing both the speed and strength of clot formation in a size-dependent manner. The findings highlight that microplastic surface chemistry and particle size play important roles in how these particles might interact with blood.
Kinetics and toxicity of nanoplastics in ex vivo exposed human whole blood as a model to understand their impact on human health
Researchers exposed human whole blood to five types of nanoplastics and found that immune cells, especially monocytes, readily absorbed the particles, triggering oxidative stress and inflammatory responses. Different plastic types caused different effects: some triggered blood clotting, others caused red blood cell damage, and PLA (a "biodegradable" plastic) was among the most reactive. This study provides direct evidence that nanoplastics reaching the human bloodstream can disrupt immune cells, blood clotting, and inflammation.
Effects of micro- and nanoplastics on blood cells in vitro and cardiovascular parameters in vivo, considering their presence in the human bloodstream and potential impact on blood pressure
This review examines evidence that micro- and nanoplastics can enter the human bloodstream and interact with blood cells, with plastic particles already detected in human blood, blood clots, and artery plaques. While direct evidence linking microplastics to blood pressure changes in humans is still lacking, animal studies and the mechanisms identified -- including blood vessel damage and inflammation -- suggest cardiovascular effects are plausible.
Environmental microplastic and nanoplastic: Exposure routes and effects on coagulation and the cardiovascular system
This review explores how environmental microplastic and nanoplastic particles may affect blood coagulation and the cardiovascular system in humans. Researchers summarized evidence suggesting that plastic particles can enter the body through ingestion, inhalation, and skin contact, potentially triggering inflammatory responses in blood vessels. The study highlights the need for more research on how chronic exposure to these tiny plastic particles may contribute to cardiovascular health risks.
Weathered microplastics in human blood: unraveling the effect of structural changes at the particle surface on coagulation and platelet activation
Researchers exposed human whole blood to microplastics that had been artificially aged to simulate real environmental weathering, finding that weathered plastics like polystyrene, PVC, and PET triggered significantly stronger blood clotting and platelet activation than fresh plastic particles. The findings suggest that the longer plastic sits in the environment and degrades, the more dangerous it may become to human cardiovascular health.
Cytotoxicity and pro-inflammatory effect of polystyrene nano-plastic and micro-plastic on RAW264.7 cells.
Researchers found that polystyrene nano-plastics (80 nm) induced apoptosis and pro-inflammatory cytokine release in mouse macrophage RAW264.7 cells at lower concentrations than micro-plastics (3 μm), with nano-plastics also enhancing phagocytic activity and activating NF-kB signaling pathways more potently than their larger counterparts.
Divergent responses of human erythrocytes to nano-, micro-, and size-mixed polystyrene particles reveal distinct cellular effects of environmental plastics
Researchers examined how different sizes of polystyrene particles affect human red blood cells in laboratory conditions. The study found that 100-nanometer particles caused shape changes in red blood cells consistent with membrane interaction, while 1-micrometer particles showed minimal effects. Notably, when both sizes were combined, they triggered cell aggregation, demonstrating that size-mixed plastic particles can produce distinct effects not seen with individual sizes alone.
Genotoxic and immunomodulatory effects in human white blood cells after ex vivo exposure to polystyrene nanoplastics
Human white blood cells were exposed ex vivo to polystyrene nanoplastics and showed DNA strand breaks, chromosomal damage, and changes in immune cell activation markers, suggesting that nanoplastics at environmentally relevant concentrations could cause genotoxic and immunomodulatory effects in people.
Cytotoxicity of amine-modified polystyrene MPs and NPs on neural stem cells cultured from mouse subventricular zone
Researchers tested the effects of polystyrene microplastics and nanoplastics with a positive surface charge on neural stem cells from mouse brains. Both sizes of particles reduced cell survival, but nanoplastics were significantly more toxic at lower concentrations, causing cell death and preventing stem cells from developing into mature brain cells. These findings suggest that nanoplastics that reach the brain could potentially harm the nervous system's ability to repair and maintain itself.
Neurotoxic potential of polystyrene nanoplastics in primary cells originating from mouse brain
Researchers exposed three types of primary mouse brain cells to 100 nm polystyrene nanoplastics and found that neurons underwent apoptosis while astrocytes survived but developed reactive astrocytosis with elevated inflammatory markers, suggesting that neuronal vulnerability to nanoplastic accumulation may be amplified by astrocyte-driven neuroinflammation.
Detrimental effects of micro- and nanoplastics (MNPs) on platelet and neutrophil immunity: Recent findings and emerging insights
Researchers reviewed how micro- and nanoplastics (MNPs) harm the immune system, finding that tiny plastic particles can trigger dangerous inflammation in platelets and neutrophils — immune cells that control clotting and infection defense. These effects could disrupt normal blood vessel function and immune balance, though the exact mechanisms by which cells take up MNPs remain poorly understood.
Internalization of nano- and micro-plastics in human erythrocytes leads to oxidative stress and estrogen receptor-mediated cellular responses.
This study exposed human red blood cells to nano- and micro-plastics of different polymer types and found that both caused oxidative stress, membrane damage, and altered cell morphology. The findings suggest that plastic particles reaching the bloodstream could impair red blood cell function, with potential cardiovascular and systemic health consequences.
Distinct targeting and uptake of platelet and red blood cell‐derived extracellular vesicles into immune cells
This study examined how tiny vesicles (small bubble-like particles) released by platelets and red blood cells interact with immune cells. Platelet-derived vesicles were taken up by certain immune cells much faster than red blood cell vesicles, and neither type affected T-cells. While not directly about microplastics, the research is relevant because it helps scientists understand how small particles in the blood, including nanoplastics, might interact with the immune system.
Microplastic particles in human blood and their association with coagulation markers
In a study of 36 healthy adults, microplastics were detected in the blood of 89% of participants, with polypropylene and polyethylene being the most common types found. Higher microplastic levels were associated with changes in blood clotting markers, suggesting that plastic particles in our bloodstream may affect how our blood coagulates, though larger studies are needed to confirm this link.
Effects of polystyrene micro/nanoplastics on liver cells based on particle size, surface functionalization, concentration and exposure period
Researchers systematically studied the effects of polystyrene micro- and nanoplastics on human liver cells, varying particle size, surface chemistry, concentration, and exposure duration. They found that smaller particles were internalized more readily and that surface functionalization significantly influenced toxicity, with aminated particles causing the most cell damage. The study suggests that particle characteristics beyond just size play an important role in determining how micro- and nanoplastics affect human cells.
Journey of micronanoplastics with blood components
This study provides the first comprehensive assessment of how micro- and nanoplastics interact with blood components after entering the human bloodstream. Researchers found that these particles can cause protein damage, red blood cell destruction, immune system activation, and blood clotting abnormalities. The findings highlight that microplastics in the bloodstream may pose a range of health risks beyond the organs where they initially enter the body.
Are all nanoplastics equally neurotoxic? Influence of size and surface functionalization on the toxicity of polystyrene nanoplastics in human neuronal cells
Researchers tested four types of polystyrene nanoplastics on human neuronal cells and found that toxicity varied dramatically depending on particle surface chemistry. Particles with amine surface groups were the most harmful, significantly reducing cell survival and causing visible damage to cell structures, while unmodified particles showed minimal toxicity, suggesting that surface properties matter as much as size when assessing nanoplastic risks.