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61,005 resultsShowing papers similar to Heavy Metals, Halogenated Hydrocarbons, Phthalates, Glyphosate, Cordycepin, Alcohol, Drugs, and Herbs, Assessed for Liver Injury and Mechanistic Steps
ClearMolecular Mechanisms of Phthalate-Induced Hepatic Injury and Amelioration by Plant-Based Principles
This review examines how phthalates, chemicals commonly added to plastics to make them flexible, damage the liver through oxidative stress, inflammation, and disruption of normal cell signaling. People are exposed to phthalates through air, water, food, and skin contact, and the liver bears the greatest burden as the primary organ for processing these chemicals. The findings are directly relevant to microplastics because phthalates can leach from plastic particles inside the body, making microplastic exposure a potential delivery route for these liver-damaging chemicals.
Methods of a Détoxification Cure, Especially for the Liver
This article outlines various approaches to liver detoxification, arguing that modern chronic disease prevalence is driven partly by accumulation of environmental toxins including microplastics, heavy metals, and pesticides. The author describes lifestyle, dietary, and therapeutic methods proposed to support hepatic toxin clearance.
The hepatotoxicity assessment of micro/nanoplastics: A preliminary study to apply the adverse outcome pathways
Researchers reviewed the literature on how micro- and nanoplastics cause liver damage and organized the findings into an Adverse Outcome Pathway framework. They found that plastic particles can trigger oxidative stress, inflammation, and metabolic disruption in the liver, potentially leading to dysfunction. The study provides a structured way to understand the chain of events from plastic particle exposure to liver harm, highlighting potential health risks for humans.
Microplastic-mediated new mechanism of liver damage: From the perspective of the gut-liver axis
This review describes how microplastics can damage the liver through the gut-liver axis: they first disrupt the gut's protective barrier and beneficial bacteria, allowing harmful substances to leak through the weakened intestinal wall into the bloodstream and travel to the liver. Once there, these substances cause inflammation, metabolic problems, and oxidative stress, offering a new explanation for how microplastic exposure could lead to liver disease.
Emerging threat of environmental microplastics: A comprehensive analysis of hepatic metabolic dysregulation and hepatocellular damage (Review)
This review summarizes existing research on how microplastics damage the liver, which is a key organ for filtering toxins from the body. Studies show that microplastics can cause liver tissue damage, trigger cell death, and disrupt fat metabolism, with smaller particles and longer exposure causing worse effects. The findings highlight the liver as a particularly vulnerable organ because it accumulates microplastics that enter the body through food and water.
Exposure to microplastics and liver oncogenesis: A comprehensive review on molecular mechanisms and pathogenic pathways
Researchers reviewed mechanisms by which microplastic exposure may promote liver cancer, identifying oxidative stress, mitochondrial dysfunction, inflammatory signaling, and epigenetic disruption as key pathways, while noting that microplastics can also carry heavy metals and organic pollutants that synergistically amplify hepatotoxic and carcinogenic risk.
Microplastics and nanoplastics: Emerging drivers of hepatic pathogenesis and metabolic dysfunction
This review examines emerging evidence linking micro- and nanoplastic exposure to liver disease, including metabolic dysfunction-associated liver disease, cirrhosis, and liver cancer. Researchers found that these particles may contribute to liver damage through oxidative stress, inflammation, and disruption of metabolic pathways. The study highlights the need for further research into how environmental plastic contamination may be influencing the rising rates of liver disease worldwide.
Examining the Pathogenesis of MAFLD and the Medicinal Properties of Natural Products from a Metabolic Perspective
This review examines the causes and potential treatments for metabolic-associated fatty liver disease (MAFLD), which affects about two-fifths of the global population. While focused on natural product remedies rather than microplastics, the metabolic pathways discussed, including lipid metabolism disruption and oxidative stress, are the same mechanisms through which microplastics have been shown to damage liver cells. Understanding these pathways helps explain how microplastic exposure could contribute to liver disease.
Nanoplastics and Microplastics May Be Damaging Our Livers
This systematic review summarizes research on how micro- and nanoplastics may damage the liver. Since the liver is the body's main detoxification organ, it plays a key role in processing plastic particles that enter the body through food, water, and air, and the evidence suggests these particles can cause inflammation, oxidative stress, and other liver problems.
Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions
This review summarizes what scientists know about how micro- and nanoplastics affect the liver, which is one of the first organs exposed because it processes everything absorbed from the gut. The particles trigger oxidative stress, disrupt energy metabolism, cause cell death, and promote inflammation, and may contribute to conditions like fatty liver disease and liver fibrosis. The paper also highlights how plastics can disturb the gut microbiome, which communicates with the liver through the gut-liver axis and may amplify liver damage.
Hepatotoxic Mechanisms of Micro- and Nanoplastics in Animal Models: A Scoping Review with Human Health Implications
This scoping review examines hepatotoxic mechanisms of micro- and nanoplastics in animal models, identifying oxidative stress, inflammation, lipid peroxidation, and epigenetic alterations as the primary pathways through which plastic particles damage liver tissue.
Potential toxicity of microplastics on vertebrate liver: A systematic review and meta–analysis
This meta-analysis of 118 studies found that microplastics damage vertebrate livers by inducing oxidative stress and intracellular toxicity, altering biotransformation processes, and disrupting lipid metabolism. Organisms at earlier life stages, exposed to smaller particles, and for longer durations showed the greatest liver damage, with catalase, GST, reactive oxygen species, and alkaline phosphatase levels progressively increasing with microplastic concentration.
Cadmium disrupts hepatic lipid homeostasis: molecular mechanisms, unresolved controversies, and therapeutic strategies
This review systematically examined how cadmium accumulates in the liver and disrupts hepatic lipid metabolism, covering mechanisms including mitochondrial dysfunction, oxidative stress, and lipid droplet accumulation. The authors also reviewed therapeutic strategies and identify persistent knowledge gaps in cadmium hepatotoxicology.
Are Ingested or Inhaled Microplastics Involved in Nonalcoholic Fatty Liver Disease?
This review explored the potential connection between microplastic exposure through ingestion and inhalation and nonalcoholic fatty liver disease, which has become a leading cause of chronic liver injury. The study discusses how dietary and environmental microplastic exposure could potentially influence liver health through mechanisms including inflammation and endocrine disruption, though further research is needed to establish definitive links.
Redox Biology and Liver Fibrosis
This review explores how disrupted redox balance in the liver contributes to the development and progression of hepatic fibrosis across various chronic liver diseases. Researchers describe how persistent damage to liver cells triggers overproduction of reactive species, which in turn activate specific signaling pathways that drive scar tissue formation. The study identifies several redox-dependent pathways as potential therapeutic targets for slowing or preventing liver fibrosis.
Nanoplastics, Liver Injury, and Oxidative Mechanisms: Translating Animal Models Into Human Risk Assessment
This scoping review synthesized evidence from animal studies on how micro- and nanoplastics cause liver injury, focusing on the underlying mechanisms of toxicity. Researchers found that oxidative stress is a principal pathway by which these particles damage liver tissue, and the study evaluates what these preclinical findings may mean for assessing human health risks from plastic particle exposure.
Hazards of microplastics exposure to liver function in fishes: A systematic review and meta-analysis
This meta-analysis found that microplastic exposure significantly impairs fish liver function, elevating key liver enzymes (AST, ALT, ALP, LDH) and triggering oxidative stress markers in liver tissue. The toxicological mechanisms include inflammation, apoptosis, and metabolic disruption, raising concerns about the health of fish populations in microplastic-contaminated waters and the safety of fish as a human food source.
Overview of the hazardous impacts of metabolism-disrupting chemicals on the progression of fatty liver diseases.
This review examined how metabolism-disrupting chemicals (MDCs)—including bisphenol A and phthalates from plastics—promote the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD). MDC exposure was found to impair liver lipid homeostasis and contribute to the global rise in fatty liver disease.
Molecular regulatory networks of microplastics and cadmium mediated hepatotoxicity from NAFLD to tumorigenesis via integrated approaches
This study mapped out how microplastics and the toxic metal cadmium work together to damage the liver, tracing a progression from fatty liver disease to cirrhosis and eventually liver cancer. Cadmium activates genes linked to cell growth and tumor formation, while microplastics trigger cell death pathways related to inflammation. When combined, the two pollutants accelerate liver damage more than either one alone, raising concerns about real-world exposure where people encounter both simultaneously.
Fish liver damage related to the wastewater treatment plant effluents
Researchers reviewed how the complex chemical mixture discharged by wastewater treatment plants damages fish liver structure and function, examining how biotransformation enzymes and antioxidant systems attempt to cope with persistent contaminants and highlighting fish biomarkers used to detect exposure.
Microplastics in focus: a silent disruptor of liver health- a systematic review
This systematic review examines how micro- and nanoplastics affect liver health, based on 25 experimental and observational studies. The evidence shows that polystyrene particles can cause liver inflammation, oxidative stress, fat buildup, and disruption of metabolic pathways. These findings are concerning because the liver is the body's primary detoxification organ, and plastic-related damage could impair its ability to process other toxins.
Dimethyl Bisphenolate Ameliorates Carbon Tetrachloride-Induced Liver Injury by Regulating Oxidative Stress-Related Genes
Researchers synthesized a novel compound called dimethyl bisphenolate and tested its ability to protect against chemically induced liver injury in rats and cell models. They found that the compound significantly reduced liver damage markers and oxidative stress in a dose-dependent manner, with effects comparable to the established liver protectant silymarin. The study suggests that dimethyl bisphenolate may help protect liver cells by regulating oxidative stress pathways and reducing cell death.
A computational framework for multi-scale data fusion in assessing the associations between micro- and nanoplastics and human hepatotoxicity
Researchers developed a computational toxicology framework integrating multi-source data and network analysis to map associations between micro- and nanoplastics and hepatotoxicity, identifying key molecular pathways through which MNPs may damage the liver, offering a scalable alternative to traditional in vivo testing.
Table 1_Microplastics in focus: a silent disruptor of liver health- a systematic review.docx
This systematic review of 25 studies found that micro- and nanoplastics can damage liver cells by causing oxidative stress, inflammation, and disrupting how the liver processes fats. These findings suggest that plastic particles small enough to reach the liver could contribute to liver disease, though more human studies are needed.