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61,005 resultsShowing papers similar to Pharmacodynamic Material Basis and Potential Mechanism Study of Spatholobi Caulis in Reversing Osteoporosis
ClearOridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells
Researchers found that oridonin, a natural plant compound, can trigger two different types of cell death simultaneously in bone cancer cells. This dual mechanism makes it effective at suppressing tumor growth in osteosarcoma. The study suggests oridonin could be a promising therapeutic agent for treating this type of bone cancer.
Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Bushen Huashi decoction against kidney stones
This study used network pharmacology and laboratory validation to reveal that a traditional Chinese herbal formula (Bushen Huashi decoction) combats kidney stones by modulating estrogen receptor, NRF2/HO-1 antioxidant, and apoptosis signaling pathways.
Dendrobine Alleviates Cellular Senescence and Osteoarthritis via the ROS/NF-κB Axis
Researchers investigated whether dendrobine, a natural compound from orchids, could reduce cellular aging and osteoarthritis symptoms in lab and animal models. They found that dendrobine decreased oxidative stress and inflammation by suppressing the ROS/NF-kB signaling pathway, which reduced cartilage breakdown and cellular senescence. The study suggests dendrobine may have potential as a therapeutic approach for age-related joint degeneration.
The potential mechanism of huazhuojiedu decoction in the treatment of ulcerative colitis based on network pharmacology and experimental validation
Researchers used network pharmacology to identify 119 active components and 146 potential targets of the traditional Chinese medicine formula Huazhuojiedu decoction relevant to ulcerative colitis, then validated key predicted mechanisms in dextran sulfate sodium-induced rat colitis models, elucidating multi-target pathways underlying the formula's clinically observed therapeutic effects.
Oral Administration of Oyster Peptide Prevents Bone Loss in Ovariectomized Mice
Researchers investigated whether oral administration of an oyster-derived peptide (P-CG-01, YRGDVVPK) could prevent bone loss in ovariectomized mice used as an osteoporosis model, finding that the peptide restored bone mineral density to sham surgery levels. The results suggest that this food-derived peptide has potential as an orally bioavailable agent for osteoporosis prevention, offering a non-injection alternative to existing peptide therapies.
RANKL/OPG axis as a therapeutic target for microplastic-induced bone loss: Mechanistic insights from transcriptomic and functional validation
This study found microplastic deposits in human bone tissue and showed that MPs disrupt bone metabolism by altering the RANKL/OPG signaling axis, a key regulator of bone remodeling. Transcriptomic and functional analyses identified therapeutic target pathways that could potentially protect against microplastic-induced bone loss.
Uncovering the Anticancer Potential of Polydatin: A Mechanistic Insight
This review examines the anticancer mechanisms of polydatin, a natural stilbenoid compound, detailing its ability to inhibit tumor growth through antioxidant, anti-inflammatory, and apoptotic pathways across multiple cancer types.
Beneficial effect of Xuebijing against Pseudomonas aeruginosa infection in Caenorhabditis elegans
Researchers found that the traditional Chinese medicine formulation Xuebijing protected Caenorhabditis elegans against Pseudomonas aeruginosa infection by enhancing immune pathways and reducing bacterial colonization, providing mechanistic insight into its clinical use for treating sepsis.
Niclosamide Inhibits Aortic Valve Interstitial Cell Calcification by Interfering with the GSK-3β/β-Catenin Signaling Pathway
Researchers found that niclosamide reduces calcification in aortic valve interstitial cells by interfering with calcification signaling pathways, suggesting a potential pharmacological approach to treating calcific aortic valve stenosis.
A Comprehensive Review of Pathological Mechanisms and Natural Dietary Ingredients for the Management and Prevention of Sarcopenia
This review explores natural dietary ingredients, including plant extracts, phytochemicals, and probiotics, that may help prevent or manage sarcopenia, the age-related loss of muscle mass and strength. Researchers found that certain compounds can influence muscle protein synthesis, reduce inflammation, and support gut health in ways that benefit muscle maintenance. The study highlights how diet-based approaches could complement exercise in preserving muscle function as people age.
Protective Effect of Paeoniae Radix Alba Carbonisata on Hepatic Amyloidosis by Regulating Calcium Homeostasis
Scientists tested a traditional Chinese herbal medicine called PRAC on a serious liver condition where harmful proteins build up and damage the organ. The herb extract helped protect liver cells and reduced inflammation by fixing problems with calcium balance inside cells. While this is early research done in lab dishes and mice, it suggests this traditional remedy might help treat certain types of liver disease, though human studies are still needed.
Polystyrene microplastics induces senescence of osteocytes by activating the cyclooxygenase-2 signaling pathway
Researchers found that polystyrene microplastics can be taken up by osteocytes, the most abundant cells in bone tissue, and cause them to undergo premature aging through a process called senescence. The microplastics triggered oxidative stress and activated a specific inflammatory signaling pathway involving cyclooxygenase-2. The study suggests that microplastic exposure could potentially impair bone health by disrupting the normal function of the cells responsible for maintaining bone tissue.
Anthocyanin-rich polyphenols from Hibiscus syriacus activate autophagy to reverse polystyrene microplastic-induced osteogenic dysfunction
Researchers found that anthocyanin-rich polyphenols from Hibiscus syriacus can restore bone cell function impaired by polystyrene microplastic exposure in both cell culture and zebrafish models. The study suggests that these plant compounds activate autophagy pathways to reverse microplastic-induced cellular aging and osteogenic dysfunction, indicating potential protective effects of dietary polyphenols against microplastic-related skeletal impacts.
Bridging relevance between microplastics, human health and bone metabolism: Emerging threats and research directions
Researchers reviewed how microplastics — tiny plastic fragments that accumulate in tissues throughout the body — may disrupt bone metabolism by triggering inflammation, oxidative stress, and hormonal interference, raising concern that widespread microplastic exposure could contribute to bone diseases like osteoporosis.
Targeting the Inflammatory Hallmarks of Obesity-Associated Osteoarthritis: Towards Nutraceutical-Oriented Preventive and Complementary Therapeutic Strategies Based on n-3 Polyunsaturated Fatty Acids
This review explored nutraceutical-oriented strategies targeting inflammatory pathways in obesity-associated osteoarthritis, examining how bioactive compounds may offer preventive and adjunctive therapeutic approaches for this increasingly prevalent condition.
Potential application of traditional Chinese medicine in cerebral ischemia—Focusing on ferroptosis
This review examined evidence for traditional Chinese medicine compounds in treating cerebral ischemia by targeting ferroptosis, an iron-dependent form of regulated cell death. Multiple TCM-derived compounds including flavonoids and alkaloids showed neuroprotective effects through ferroptosis pathway inhibition in experimental ischemia models.
Micro/nanoplastic-driven cardiovascular senescence and multi-target intervention by traditional Chinese medicine
Researchers reviewed how micro- and nanoplastics accumulate in cardiovascular tissues and accelerate cellular aging through mitochondrial damage, epigenetic changes, telomere shortening, and chronic inflammation, while also highlighting traditional Chinese medicine's multi-target compounds as a potential countermeasure by simultaneously addressing oxidative stress, fibrosis, and cell death pathways.
Jianwei Xiaoshi oral liquid attenuates high-calorie diet-induced dyspepsia in immature rats via regulating the pancreatic secretion pathway and maintaining the homeostasis of intestinal microbiota
Researchers found that a traditional Chinese herbal medicine formula called Jianwei Xiaoshi oral liquid improved functional digestive problems in young rats fed a high-calorie diet by regulating eight key proteins involved in pancreatic digestion and restoring healthy gut bacteria balance. The findings suggest potential therapeutic benefits of this herbal remedy for diet-induced digestive disorders in children.
Mechanisms underlying the therapeutic effects of Semen cuscutae in treating recurrent spontaneous abortion based on network pharmacology and molecular docking
Researchers used network pharmacology and molecular docking to investigate how compounds from the traditional Chinese medicine Semen cuscutae may interact with inflammatory targets related to recurrent spontaneous abortion. The study identified sesamin as a key compound that showed strong binding affinity to relevant molecular targets, providing a theoretical basis for further investigation of this traditional remedy.
Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of salidroside on intestine ischemia reperfusion
Researchers investigated the therapeutic mechanism of salidroside for intestinal ischemia-reperfusion injury using network pharmacology and experimental validation, finding that it may target AMPK and TXNIP domains to provide protective effects.
Integration of transcriptomics and metabolomics reveals the mechanism of Lycium barbarum polysaccharides inhibited MCF-7 cell proliferation
Researchers used transcriptomics and metabolomics to investigate how Lycium barbarum polysaccharides inhibit MCF-7 breast cancer cell proliferation, identifying the molecular mechanisms and signaling pathways responsible for the compound's anticancer activity at an optimal dose of 8 mg/mL.
Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis
This systematic review found a strong trend toward using graphene oxide-based nanomaterials for treating osteosarcoma (bone cancer), leveraging their thermal and anti-cancer properties. Photodynamic therapy, photothermal therapy, and nanocarrier delivery systems using GO showed promise as non-invasive, targeted alternatives to conventional bone cancer treatments.
The Traditional Chinese Medicine in Treating Diabetic Nephropathy: A Bibliometric Analysis
This bibliometric analysis reviews research trends on Traditional Chinese Medicine for treating diabetic nephropathy. The study identifies key research hotspots including the clinical efficacy of herbal treatments and their pharmacological mechanisms, with improving oxidative stress and regulating gut microbiota highlighted as promising directions for future investigation.
Potential threats of environmental microplastics to the skeletal system: current insights and future directions
This review summarizes emerging evidence that micro- and nanoplastics may reach the skeletal system through the bloodstream and accumulate in bone tissue. Researchers highlight potential effects on bone-forming and bone-resorbing cells, which could disrupt normal bone maintenance. The study calls attention to an underexplored area of microplastic health research and outlines directions for future investigation.