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61,005 resultsShowing papers similar to New insight into long-term effects of phthalates microplastics in developing zebrafish: Evidence from genomic alteration and organ development
ClearInvestigating the Release and Toxicity of Microplastics/Nanoplastics From Single‐Use Plastic Bags to Zebrafish
Researchers studied how single-use polyethylene bags break down under environmental conditions and tested the resulting microplastic and nanoplastic particles on zebrafish embryos. The fragments released from degraded bags showed higher toxicity than pure polyethylene particles, causing dose-dependent developmental abnormalities including pericardial edema, spinal curvature, and mortality rates up to 93% at the highest concentrations, likely due to chemical additives and degradation products.
Toxic effects of environmental-relevant exposure to polyethylene terephthalate (PET) micro and nanoparticles in zebrafish early development
Researchers exposed zebrafish embryos to PET plastic micro and nanoparticles at levels found in the environment and observed toxic effects including reduced tail movement, faster heart rates, and changes in eye development. The smaller nanoplastic particles were especially concerning because they are more easily absorbed by developing organisms. These findings suggest that PET plastic pollution in water could harm fish development, raising questions about effects on other species exposed through contaminated water.
Exploring developmental toxicity of microplastics and nanoplastics (MNPS): Insights from investigations using zebrafish embryos
This review summarizes research on how micro- and nanoplastics harm embryo development using zebrafish as a model organism that shares genetic similarities with humans. Studies show these tiny plastic particles cause damage to the brain, heart, gut, and immune system of developing embryos, largely through oxidative stress and cell death pathways.
Effects on Zebrafish of Chemical Contaminants and Additives Present in Microplastics
Researchers fed zebrafish for 60 days on diets containing 10% environmental microplastics collected from beaches in Lanzarote and Tenerife, alongside clean pellet and control groups, then analyzed chemical contaminants in tissues by liquid chromatography coupled to high-resolution mass spectrometry. Results confirmed bioaccumulation of plastic additives and chemical contaminants in zebrafish tissues over time, with plastic synthesizers reaching the highest tissue concentrations followed by plasticizers.
The combined toxicity assessment of polystyrene microplastics and di(2-ethylhexyl) phthalate on cardiac development in zebrafish embryos
Researchers studied the combined toxic effects of polystyrene microplastics and the plasticizer DEHP on heart development in zebrafish embryos. They found that co-exposure significantly reduced heart rate and survival, increased oxidative stress and cell death, and enlarged the heart structure. The study identifies specific metabolic and signaling pathways involved in cardiac toxicity, suggesting that the combination of microplastics and their chemical additives may pose greater risks to heart development than either alone.
Impacts of real microplastic leachates on the development and behavior of developing zebrafish (Danio rerio)
This study exposed developing zebrafish to leachates from real-world microplastic samples and found that the chemical additives released—rather than the particles themselves—impaired early neurodevelopment and altered larval swimming behavior.
Combined Toxicities of Di-Butyl Phthalate and Polyethylene Terephthalate to Zebrafish Embryos
Researchers exposed zebrafish embryos to polyethylene terephthalate microplastics and the plasticizer di-butyl phthalate, both alone and in combination. While the microplastics alone mainly delayed hatching, the plasticizer caused severe developmental abnormalities and death. The study found that the microplastics actually reduced the toxicity of the plasticizer by adsorbing it, though they also slowed its breakdown, creating a more persistent exposure risk.
Effects of pristine or contaminated polyethylene microplastics on zebrafish development
Researchers examined the effects of both pristine and pollutant-contaminated polyethylene microplastics on zebrafish development through chronic exposure. The study assessed how microplastics, both alone and as carriers of adsorbed organic pollutants, affect developing fish. The findings provide new insights into how contaminated microplastics may create additional routes for toxic compounds to enter aquatic food webs.
The combined toxic effects of polyvinyl chloride microplastics and di(2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio)
Researchers studied the combined toxic effects of PVC microplastics and the plasticizer DEHP on zebrafish embryos and larvae. While PVC alone slowed hatching and increased death rates, the combination of PVC and DEHP actually showed some antagonistic effects, reducing certain types of damage compared to individual exposures. The study provides insight into how microplastics and their associated chemicals may interact in complex ways when organisms are exposed to them together in natural waters.
A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo
Researchers exposed zebrafish embryos to nanoplastics made from PET, the plastic commonly used in water bottles and food packaging. The nanoplastics accumulated in the liver, intestine, and kidneys, causing oxidative stress, damaging cell energy systems, and disrupting metabolism. This is the first comprehensive study of PET nanoplastic toxicity mechanisms, and it is particularly relevant because PET is one of the most common plastics that humans encounter daily.
Recycled polyvinyl chloride microplastics: investigation of environmentally relevant concentrations on toxicity in adult zebrafish
Researchers investigated the toxicity of recycled PVC microplastics at environmentally relevant concentrations in adult zebrafish, finding that these particles release chemicals that cause measurable toxic effects in exposed organisms.
In vivo toxicity of Dioctyl Phthalate in adult and zebrafish larvae.
Researchers tested the toxicity of the plasticizer dioctyl phthalate on zebrafish embryos and adults, finding developmental abnormalities and dose-dependent organ damage including fatty liver, renal necrosis, and oligospermia, with larvae more sensitive than adults.
Behavioural impact of microplastics on zebrafish development
Researchers assessed the developmental effects of environmentally relevant, household-derived microplastic fragments on zebrafish, rather than the pristine polymer spheres typically used in lab studies. While exposure did not cause embryonic death or gross malformations, the study found significant sublethal effects including reduced touch-evoked escape responses in larvae, suggesting behavioral impacts from realistic microplastic exposure.
Effect of Early-Life Exposure of Polystyrene Microplastics on Behavior and DNA Methylation in Later Life Stage of Zebrafish
Researchers exposed zebrafish embryos to polystyrene microplastics during early development and then assessed neurobehavioral effects later in life. The study found that early-life microplastic exposure caused lasting changes in behavior and DNA methylation patterns, suggesting that developmental exposure to microplastics may have long-term epigenetic consequences on neurodevelopment.
Plastic leachate-induced toxicity during sea urchin embryonic development: Insights into the molecular pathways affected by PVC
Researchers found that chemical leachates from PVC microplastics disrupted sea urchin embryonic development, revealing molecular pathway alterations in skeletal formation and stress responses that highlight a previously underexplored route of developmental ecotoxicity.
Effects of Microplastics and Nanoplastics on Neurodevelopment and Neurodegeneration in Zebrafish
This review covers how micro- and nanoplastic (MNP) exposure affects neurodevelopment and neurodegeneration in zebrafish, summarising evidence on impaired neurodevelopment, behavioural changes, and markers of neurodegeneration from studies using various polymer types and exposure routes. It frames zebrafish as a key model for understanding MNP neurotoxicity.
Unravelling the developmental toxicity of heavy metals using zebrafish as a model: a narrative review
This review summarizes research on how heavy metals, including cadmium, lead, mercury, and arsenic, harm developing zebrafish embryos, which share about 80% of their genes with humans. These metals cause oxidative stress, disrupt brain development, and trigger cell death at environmentally relevant levels. The findings are relevant to microplastics research because microplastics can carry and concentrate these same heavy metals, potentially worsening their toxic effects on human development.
Research progress of model animal zebrafish in toxicity evaluation of microplastics
This review examines the use of zebrafish as a model organism for evaluating the toxicity of microplastics, synthesizing research on how microplastic exposure affects development, reproduction, and physiological function in this well-established vertebrate model. The authors highlight zebrafish as a particularly valuable system for mechanistic toxicology studies given its genetic tractability and the breadth of endpoints assessable across life stages.
Embryotoxicity of polystyrene microplastics in zebrafish Danio rerio
Researchers exposed zebrafish embryos to polystyrene microplastics during early development and observed serious physical deformities, particularly in the spine, tail, and eyes, despite no increase in mortality. The exposed larvae also showed elevated expression of genes involved in oxidative stress defense and cellular detoxification. The findings suggest that microplastics can disrupt critical developmental stages in freshwater fish even when they do not directly cause death.
Morphometric effects of various weathered and virgin/pure microplastics on sac fry zebrafish (Danio rerio)
Researchers exposed sac fry zebrafish (Danio rerio) to weathered and virgin microplastics of various polymer types and found significant morphometric developmental effects, with weathered plastics generally causing greater biological harm than virgin counterparts due to differences in surface chemistry and plasticizer content.
Accumulation and Distribution of Fluorescent Microplastics in the Early Life Stages of Zebrafish
Researchers tracked the accumulation and distribution of fluorescent microplastics in early life stages of a freshwater organism, finding that microplastics were taken up and distributed across body tissues. The results help explain how microplastics accumulate in young aquatic organisms and potentially affect their development.
Microplastics alter development, behavior, and innate immunity responses following bacterial infection during zebrafish embryo-larval development
Researchers found that polystyrene microplastics altered zebrafish larval development, behavior, and innate immune responses in a timing-dependent manner, with early embryonic exposure through the egg chorion amplifying susceptibility to subsequent bacterial infection.
Acute toxic effects of polyethylene microplastic on adult zebrafish
Researchers exposed adult zebrafish to polyethylene microplastics of various sizes to identify physical effects, behavioral changes, and gene expression impacts. They found that microplastic ingestion varied by particle size and that exposure altered expression of detoxification and reproduction-related genes. The study suggests that microplastic pollution at environmentally relevant concentrations could affect both the health and reproductive capacity of fish.
Adverse effects of plastic leachate and its component 2,4-DTBP on the early development of zebrafish embryos
Researchers found that leachate from UV-aged agricultural plastic mulch films causes mortality, malformation, and reduced hatching in zebrafish embryos, and identified the phenolic antioxidant additive 2,4-di-tert-butylphenol as a contributor that disrupts fat digestion, pancreatic function, and energy metabolism at the transcriptomic level.