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61,005 resultsShowing papers similar to Malathion-induced Biochemical and Molecular Changes in the Brain of Danio rerio as Biomarkers of Oxidative Stress Damage
ClearExposure to Acute Concentration of Malathion Induced Behavioral, Hematological, and Biochemical Toxicities in the Brain of Labeo rohita
Researchers exposed Labeo rohita fish to acute concentrations of the pesticide malathion and measured toxic effects on blood chemistry and brain biochemistry. While this study focuses on pesticide toxicity rather than microplastics directly, it demonstrates how chemical pollutants found alongside microplastics in waterways can harm aquatic organisms. The findings showed significant disruption of brain enzymes and blood parameters, highlighting the vulnerability of commercially important fish to agricultural runoff.
Current Aspects on the Plastic Nano- and Microparticles Toxicity in Zebrafish—Focus on the Correlation between Oxidative Stress Responses and Neurodevelopment
This review examines how nano- and micro-sized plastic particles cause toxic effects in zebrafish, focusing on the link between oxidative stress and neurodevelopmental damage. Researchers found that plastic particle exposure disrupts the balance of reactive oxygen species in cells, which can impair brain development and nervous system function. The study suggests these oxidative stress responses may serve as early warning signals of plastic particle toxicity in aquatic organisms.
Alteration in the Antioxidant Enzymes Activities as Potential Biomarkers for Identification of Stress Caused by Afidopyropen Intoxication in Cyprinus Carpio.
This paper is not relevant to microplastics research — it studies oxidative stress biomarkers in common carp (Cyprinus carpio) exposed to afidopyropen, a synthetic insecticide, with no connection to plastic pollution.
Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism
This review examines how microplastics, pesticides, and nanoparticles harm fish by causing oxidative stress, DNA damage, immune system disruption, and changes in gut bacteria. Since contaminated fish is a major pathway for microplastics and pesticides to enter the human diet, declining fish health and quality directly affect food safety and human nutrition worldwide.
IDENTIFYING AN OXIDATIVE STRESS RESPONSE IN ZEBRAFISH (Danio rerio) FED WITH MICROPLASTICS
Researchers fed zebrafish four different diets including commercial fish flakes, virgin pellets, and microplastics collected from two Canary Island beaches for 60 days, measuring catalase, glutathione-S-transferase, lipid peroxidation, and electron transport system activity at four time points. GST generally increased across all treatments, while CAT and ETS showed variable patterns, indicating an enzymatic stress response influenced by microplastic origin and composition.
Do Microplastics Have Neurological Implications in Relation to Schizophrenia Zebrafish Models? A Brain Immunohistochemistry, Neurotoxicity Assessment, and Oxidative Stress Analysis
Zebrafish exposed to microplastics showed increased brain damage and oxidative stress, especially when combined with chemicals that mimic schizophrenia-related conditions. The study suggests microplastics may worsen neurological problems by interacting with other brain-altering substances, highlighting potential concerns about how plastic pollution could contribute to neuropsychiatric disorders.
Abamectin Causes Neurotoxicity in Zebrafish Embryos
This study found that abamectin, a widely used agricultural pesticide, caused brain damage and nerve cell death in developing zebrafish embryos through oxidative stress. While not about microplastics, the research is relevant because microplastics can absorb and transport pesticides like abamectin through water systems, potentially delivering concentrated doses to aquatic organisms. Understanding pesticide neurotoxicity helps explain how chemical-laden microplastics could harm both wildlife and human nervous system development.
Biomarker responses in zebrafish (Danio rerio) following long-term exposure to microplastic-associated chlorpyrifos and benzo(k)fluoranthene
Researchers examined long-term exposure effects of microplastic-associated chlorpyrifos and benzo(k)fluoranthene on zebrafish, finding that pollutants sorbed to microplastics elicited biomarker responses indicating oxidative stress and neurotoxicity under chronic exposure conditions.
Genotoxic and Oxidative Damage of Environmental Pollutant Microplastics on Zebrafish (Danio rerio)
Researchers exposed zebrafish to polystyrene and polyethylene microplastics at different concentrations for up to 21 days to measure oxidative stress and DNA damage. The study found that both types of microplastics disrupted the antioxidant system and caused measurable DNA damage, with effects depending on dosage and exposure time. These results suggest that microplastics in waterways could pose genetic and cellular risks to aquatic life.
Evaluation of Detoxification‐Related Gene Expression, Oxidative Stress Biomarkers, and Blood Biochemical Parameters in Common Carp ( Cyprinus carpio ) Co‐Exposed to Polyethylene Microplastics and Deltamethrin
Researchers investigated whether polyethylene microplastics worsen the toxic effects of the insecticide deltamethrin in juvenile common carp over a 30-day exposure. The study found that co-exposure to microplastics and deltamethrin affected detoxification-related gene expression, oxidative stress biomarkers, and blood biochemistry, suggesting that microplastics can modify the bioavailability and toxicity of co-occurring pesticides in fish.
Combined effects of microplastics and copper on oxidative responses in zebrafish (Danio rerio)
Researchers exposed zebrafish (Danio rerio) to microplastics (10 µg/L) and copper (45 µg/L) individually and in combination, finding that fish exposed to both stressors simultaneously exhibited higher oxidative stress across multiple body organs than those exposed to either contaminant alone.
Toxicity evaluation of the combination of emerging pollutants with polyethylene microplastics in zebrafish: Perspective study of genotoxicity, mutagenicity, and redox unbalance
Researchers exposed adult zebrafish to polyethylene microplastics combined with a mixture of common water pollutants for 15 days and assessed DNA damage, mutation rates, and oxidative stress. They found that microplastics alone caused DNA damage and nuclear abnormalities as severe as those caused by the pollutant mixture, challenging the assumption that microplastics are less harmful than chemical contaminants. The study revealed that the fish's antioxidant defenses were overwhelmed across multiple organs, suggesting widespread oxidative damage from microplastic exposure.
Toxic effect of chronic exposure to polyethylene nano/microplastics on oxidative stress, neurotoxicity and gut microbiota of adult zebrafish (Danio rerio)
Researchers exposed adult zebrafish to polyethylene microplastics and nanoplastics for 21 days and found both caused oxidative damage to organs, disrupted brain function, and altered gut bacteria. Surprisingly, the toxic effects of microplastics and nanoplastics were similar in terms of brain and gut impacts, though organ-level oxidative damage varied by tissue type. These findings are concerning because they show that the plastic particles commonly found in food and water can simultaneously harm the brain, gut, and vital organs.
Toxic effects on bioaccumulation, hematological parameters, oxidative stress, immune responses and neurotoxicity in fish exposed to microplastics: A review
This review summarizes how microplastics affect fish health, covering toxic effects on blood, immune system, nervous system, and the buildup of plastics in fish tissues. Microplastics that accumulate in fish can trigger oxidative damage, weaken immune responses, and impair brain-related enzyme activity. Since fish are a major protein source for humans, understanding how microplastics harm fish health is directly relevant to the safety of our food supply.
A meta-analysis of potential biomarkers associated with microplastic ingestion in marine fish
This meta-analysis found that microplastic exposure induces oxidative stress in marine fish, activating antioxidant defense enzymes like superoxide dismutase and catalase while inhibiting acetylcholinesterase. Both laboratory experiments and wild fish studies confirmed these harmful biochemical responses, indicating that environmental microplastic levels are already causing measurable physiological damage to marine species.
Antioxidants and molecular damage in Nile Tilapia (Oreochromis niloticus) after exposure to microplastics
Researchers exposed juvenile Nile Tilapia to different concentrations of microplastics for 15 days followed by a recovery period. The study found dose-dependent increases in oxidative stress markers, DNA fragmentation, and altered protein patterns in fish exposed to microplastics. Evidence indicates that while fish exposed to the lowest concentration recovered after the treatment ended, higher doses caused more persistent damage.
Neurotoxicity of Some Environmental Pollutants to Zebrafish
This review examines how environmental pollutants including microplastics, pesticides, and drug residues can damage the nervous system, using zebrafish as a model organism. The studies show that microplastics can cause neurotoxic effects on their own and also increase the brain-damaging potential of other pollutants they carry, which has implications for understanding how these contaminants might affect the human nervous system.
Effects of microplastics on the accumulation and neurotoxicity of methylmercury in zebrafish larvae
Researchers found that microplastics can adsorb methylmercury and act as carriers, increasing its accumulation in zebrafish larvae and worsening neurotoxicity by disrupting locomotor activity and triggering oxidative stress.
Toxic effects of naturally-aged microplastics on zebrafish juveniles: A more realistic approach to plastic pollution in freshwater ecosystems
Researchers exposed juvenile zebrafish to naturally aged polystyrene microplastics at environmentally relevant concentrations for five days. They found that the microplastics disrupted the fish's antioxidant defenses, indicating oxidative stress, and caused measurable cellular and neurological impacts. The study suggests that even short-term exposure to realistic levels of weathered microplastics can affect the health of freshwater organisms.
Neurological effects induced by micro- and nanoplastics in fish: a systematic review and meta-analysis
This meta-analysis pooled data from 59 controlled studies and found that micro- and nanoplastics cause significant neurological effects in fish, including reduced brain antioxidant defenses and altered behavior. These findings are concerning because they suggest plastic pollution may disrupt nervous system function across species, and contaminated fish is a major part of the human diet.
Interaction of Microplastic Presence and Oxidative Stress in Freshwater Fish: A Regional Scale Research, East Anatolia of Türkiye (Erzurum & Erzincan & Bingöl)
Researchers found microplastics in multiple fish species from rivers in eastern Turkey, with black fragments and fibers predominating, and detected elevated oxidative stress markers in fish liver tissue, with the highest reactive oxygen species levels in fish from Bingöl province.
Combined neurotoxicity of aged microplastics and thiamethoxam in the early developmental stages of zebrafish (Danio rerio)
This study found that aged (weathered) microplastics combined with the insecticide thiamethoxam caused worse neurological damage to zebrafish larvae than either pollutant alone. The combined exposure reduced heart rate and movement, disrupted antioxidant defenses, and altered neurotransmitter levels in ways that were synergistic rather than simply additive. This is relevant to human health because both microplastics and pesticides are common in the environment, and their combined effects may pose greater risks than either one individually.
Toxicological assessment of nanoparticles and microplastics
This review examines the toxicological effects of nanoparticles and microplastics on aquatic organisms, summarizing mechanisms of harm including oxidative stress, inflammatory responses, DNA damage, tissue injury, and neurological disruption in fish. It highlights that secondary nanoplastics formed from macro- and microplastic degradation are more heterogeneous than primary particles, and that combined exposure with chemical pollutants amplifies toxicity, including the capacity to cross the blood-brain barrier in fish.
Polyethylene microplastic exposure and concurrent effect with Aeromonas hydrophila infection on zebrafish
Researchers found that polyethylene microplastic exposure in zebrafish caused oxidative stress, altered antioxidant enzyme activity, and induced intestinal damage, with concurrent Aeromonas hydrophila infection amplifying these toxic effects and increasing mortality rates.