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61,005 resultsShowing papers similar to Perturbation of Nanoplastics on Biomembranes: Molecular Insights from Neutron Scattering
ClearPerturbation of Nanoplastics on Biomembranes: Molecular Insights from Neutron Scattering
Using neutron scattering, researchers found that polystyrene nanoplastics — with and without surface modifications — perturb the structure and dynamics of both simple and complex bacterial-model biomembranes, suggesting nanoplastics can physically disrupt cell membrane function.
Perturbation of Nanoplastics on Biomembranes: Molecular Insights from Neutron Scattering
Scientists found that tiny plastic particles called nanoplastics can seriously damage cell membranes, which are the protective barriers around our cells. The plastic particles caused membranes to break apart and get thinner, though some natural cell types were more resistant to damage than others. This research helps us understand why the growing amount of plastic pollution in our environment and food could pose health risks to humans.
Interaction of Polystyrene Nanoplastic with Lipid Membranes
Researchers investigated how polystyrene nanoplastics derived from food packaging interact with lipid membranes, which serve as models for cell membranes. Using microscopy and molecular dynamics simulations, the study found that while water molecules initially act as a barrier to nanoplastic entry, once particles penetrate the membrane's polar region they rapidly move into the bilayer interior, and small-molecule additives like unreacted monomers can be released into the membrane during this process.
Polystyrene-Induced Dehydration of Lipid Membranes: Insights from Atomistic Simulations
Atomistic molecular dynamics simulations revealed that polystyrene nanoplastics cause dehydration of lipid membranes upon contact, extracting water molecules from the bilayer interface in ways that could alter membrane structure and function relevant to cellular uptake of nanoplastic particles.
Nanoplastic-Induced Disruption of DPPC and Palmitic Acid Films: Implications for Membrane Integrity
Researchers studied how nanoplastics interact with lung and cell membrane lipids at the molecular level. They found that polystyrene nanoplastics can physically insert themselves into lipid films that mimic cell membranes, with greater disruption at higher concentrations. These findings help explain how nanoplastics may penetrate cellular barriers, potentially affecting lung function and allowing the particles to accumulate in biological tissues.
Polystyrene-InducedDehydration of Lipid Membranes:Insights from Atomistic Simulations
Researchers conducted atomistic simulations to examine how polystyrene nanoplastics induce dehydration in lipid bilayer membranes after penetrating the membrane interior. The simulation results provided molecular-level evidence that nanoplastic-membrane interactions cause lipid dehydration, offering mechanistic insight into how nanoplastics may disrupt cellular membrane function.
Polystyrene-InducedDehydration of Lipid Membranes:Insights from Atomistic Simulations
Researchers used atomistic molecular dynamics simulations to investigate how polystyrene nanoplastics interact with lipid bilayer membranes after penetrating them, focusing specifically on whether and how such particles induce membrane dehydration. They found that polystyrene nanoplastics cause significant dehydration of lipid membranes, providing new mechanistic insight into nanoplastic-induced cellular disruption.
Polystyrene-InducedDehydration of Lipid Membranes:Insights from Atomistic Simulations
Researchers used atomistic molecular dynamics simulations to investigate the dehydration of lipid membranes caused by polystyrene nanoplastics that have penetrated the bilayer. The findings revealed how nanoplastic particles alter the hydration state of membrane lipids, providing detailed mechanistic understanding of nanoplastic interactions with biological membranes.
Polystyrene-InducedDehydration of Lipid Membranes:Insights from Atomistic Simulations
Researchers performed atomistic molecular dynamics simulations to characterize how polystyrene nanoplastics interact with and dehydrate lipid bilayer membranes following membrane penetration. The simulations revealed the structural and thermodynamic mechanisms by which nanoplastic particles disrupt membrane hydration, contributing to understanding of nanoplastic toxicity at the cellular level.
Surface-Functionalized Polystyrene Nanoparticles Alter the Transmembrane Potential via Ion-Selective Pores Maintaining Global Bilayer Integrity
Polystyrene nanoparticles were found to adsorb onto phospholipid bilayer membranes, forming disordered films that create ion-selective pores without disrupting global membrane integrity. These pores altered transmembrane electrical potential, suggesting a molecular mechanism by which nanoplastics could interfere with cellular function.
Nanoplastic ShapeEffects on Lipid Bilayer Permeabilization
Researchers investigated how nanoplastic shape affects lipid bilayer permeabilisation, demonstrating that morphologically diverse environmental nanoplastics interact with cell membranes in ways that differ substantially from the uniform polystyrene nanospheres typically used in laboratory studies.
Polystyrene and polyethylene perturb the structure of membrane: An experimental and computational study
Researchers combined cell experiments, molecular dynamics simulations, and toxicogenomic analysis to show that polystyrene and polyethylene nanoplastics — individually and as a mixture — physically penetrate cell membranes and form pores, with the mixture producing stronger disruption than either polymer alone.
Nanoplastic Shape Effects on Lipid Bilayer Permeabilization
Researchers investigated how nanoplastic shape and lipid bilayer composition jointly influence particle-membrane interactions, finding that environmentally realistic irregular nanoplastic morphologies disrupt lipid membranes differently than the pristine polystyrene nanospheres used in most prior studies.
Interaction ofPolystyrene Nanoplastic with LipidMembranes
Researchers investigated how polystyrene nanoplastics derived from disposable food packaging interact with zwitterionic lipid membranes used as protein-free cell membrane models, combining microscopic imaging with unbiased atomistic molecular dynamics simulations. The study aimed to elucidate the molecular-level mechanisms of nanoplastic internalization, which begins with initial membrane interaction steps.
Can Nanoplastics Alter Cell Membranes?
Researchers used molecular dynamics simulations to show that polyethylene nanoplastics dissolve into the hydrophobic core of lipid bilayers as disentangled polymer chains, inducing structural and dynamic changes that alter vital cell membrane functions and may result in cell death.
Understanding the transformations of nanoplastic onto phospholipid bilayers: Mechanism, microscopic interaction and cytotoxicity assessment
Researchers used molecular dynamics simulations to model how five types of nanoplastics (PVC, PS, PLA, PP, PET) interact with cell membrane lipid bilayers, finding that van der Waals forces dominate uptake and that nanoplastic accumulation reduces membrane thickness in a way that correlates with cytotoxicity.
The effects of adsorbed benzo(a)pyrene on dynamic behavior of polystyrene nanoplastics through phospholipid membrane: A molecular simulation study
Researchers used molecular simulations to show that benzo(a)pyrene adsorbed onto polystyrene nanoplastics alters how the particles interact with and penetrate phospholipid membranes, suggesting that pollutant-coated nanoplastics may pose different biological risks than pristine ones.
Nanoplastic-induced Disruption of DPPC and Palmitic Acid Monolayers: Implications for Membrane Integrity
Polystyrene nanoplastics were found to disrupt DPPC and palmitic acid lipid monolayers—models of lung alveolar and cell membranes—suggesting that inhaled or ingested nanoplastics could compromise lung alveolar stability, cell signaling, nutrient delivery, and potentially cause neurotoxicity through membrane disruption.
Interfacial Interactions between Nanoplastics and Biological Systems: toward an Atomic and Molecular Understanding of Plastics-Driven Biological Dyshomeostasis
This study investigated how nanoplastics interact with biological molecules at the atomic level, finding that polystyrene nanoplastics can destroy the structure of proteins, disrupt cell membranes, and damage DNA. The nanoplastics essentially unfolded a milk protein, punched holes in cell membranes, and broke DNA strands. These findings help explain at a fundamental level how nanoplastics found in human blood, milk, and tissues could cause the inflammation and disease seen in other studies.
Nanoplastic-InducedDisruption of DPPC and PalmiticAcid Films: Implications for Membrane Integrity
Researchers investigated how polystyrene nanoplastics disrupt model lung surfactant films composed of DPPC and palmitic acid, finding that nanoplastics intercalate into and destabilize these lipid membranes in ways that could impair respiratory function in people who inhale plastic particles.
Effects of Nanoplastics on Lipid Membranes and Vice Versa: Insights from All-Atom Molecular Dynamics Simulations
Researchers used molecular dynamics simulations to study how polyethylene nanoplastics interact with cell membrane models. They found that the mechanical properties of the lipid membrane, rather than the nanoplastic structure, primarily determine whether particles can penetrate cells. The study suggests that more flexible biological membranes may be more susceptible to nanoplastic penetration, providing insight into how these particles could enter living cells.
Nanosized microplastics damage cell membranes by altering lateral and transverse distributions of cholesterol
Researchers used atomic-scale molecular dynamics simulations to investigate how nanosized polystyrene microplastics interact with cholesterol-containing model cell membranes, examining changes to lateral and transverse cholesterol distributions. The simulations reveal that nanoplastic particles disrupt membrane organization by altering cholesterol positioning, providing a molecular mechanism for the membrane damage associated with nanoplastic exposure.
The effects of size and surface functionalization of polystyrene nanoplastics on stratum corneum model membranes: An experimental and computational study
Researchers studied how polystyrene nanoplastics of different sizes and surface modifications interact with the outermost layer of human skin, the stratum corneum. Using both experiments and computer simulations, they found that particle size and surface chemistry significantly affected how nanoplastics disrupted skin barrier membranes. The study provides early evidence that nanoplastics could potentially compromise the skin's protective barrier, which is relevant to understanding dermal exposure risks.
Nanoplastic ShapeEffects on Lipid Bilayer Permeabilization
Researchers examined how nanoplastic particle shape and lipid composition together determine the degree of membrane disruption, finding that irregular environmentally weathered nanoplastic shapes — unlike pristine spherical nanoparticles — produce distinct permeabilisation effects on lipid bilayers.