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Papers
61,005 resultsShowing papers similar to Nanoparticle delivery of TFOs is a novel targeted therapy for HER2 amplified breast cancer
ClearFunctionalized siRNA-chitosan nanoformulations promote triple-negative breast cancer cell death via blocking the miRNA-21/AKT/ERK signaling axis: in-silico and in vitro studies
This study developed nanoparticles made from chitosan (a natural material) loaded with gene-silencing molecules to target triple-negative breast cancer cells. While not about microplastics, this research uses nanoscale particle technology similar to what is studied in nanoplastic research, and the chitosan-based delivery system demonstrates how tiny particles can penetrate cells and alter gene activity -- the same mechanisms that make nanoplastics concerning for human health.
Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment
This review covers advances in targeted drug delivery using nanotechnology, including nanoparticles and liposomes designed to release medications precisely where needed in the body. While focused on cancer treatment, the drug delivery technologies discussed are relevant to understanding how nanoscale plastic particles may also travel through the body and accumulate in specific tissues.
Co-Delivery of Ylang Ylang Oil of Cananga odorata and Oxaliplatin Using Intelligent pH-Sensitive Lipid-Based Nanovesicles for the Effective Treatment of Triple-Negative Breast Cancer
Researchers developed pH-responsive nanoparticles that co-deliver a plant essential oil and a chemotherapy drug to triple-negative breast cancer cells. The smart nanoparticles release their payload more effectively in the acidic environment around tumors, improving cancer cell killing. While not related to microplastics, this nanotechnology research advances drug delivery methods that could eventually help address health effects of environmental nano-contaminants.
Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance
This review explores how nanotechnology is being used to overcome drug resistance in cancer treatment, using materials like carbon nanotubes, dendrimers, and liposomes to deliver drugs more precisely to tumors. While not directly about microplastics, the nanomaterial strategies discussed share relevance with understanding how nano-sized plastic particles interact with human cells and tissues.
Nanomaterials in Drug Delivery: Strengths and Opportunities in Medicine
This review covers how nanomaterials are being used to improve drug delivery for treating cancer and infections, offering better targeted therapy with fewer side effects. While not directly about microplastics, the research on how nanoparticles interact with human tissues provides insight into how similarly sized nanoplastics might behave once inside the body.
Nanoparticles in Drug Delivery
This review examines how nanoparticles made from various materials, including polymers, are being developed for targeted drug delivery across biological barriers. Researchers highlighted advances in stimuli-responsive nanoparticle engineering for tumor targeting and the integration of AI models for personalized medicine. While focused on biomedical applications, the study is relevant to understanding how polymer-based particles interact with biological systems at the nanoscale.
Engineered dsRNA–protein nanoparticles for effective systemic gene silencing in plants
Researchers engineered protein-RNA nanoparticles that achieved systemic gene silencing in tobacco and poplar plants. The study demonstrated that cationized bovine serum albumin can bind double-stranded RNA to form nanocomplexes that travel long distances within plants, representing an advance in agricultural biotechnology rather than microplastic research.
Iron Oxide Nanoparticles: Selectively Targeting Melanoma Cells In Vitro by Inducing DNA Damage via H2AX Phosphorylation and Hindering Proliferation through ERK Dephosphorylation
Researchers investigated iron oxide magnetic nanoparticles and found they selectively target melanoma cancer cells while sparing healthy skin cells. The nanoparticles triggered DNA damage and blocked cell growth signals specifically in melanoma cells, and their effectiveness was further enhanced using magnetic heating. The study explores a nanotechnology-based approach to cancer treatment rather than microplastic-related research.
Construction and application of star polycation nanocarrier-based microRNA delivery system in Arabidopsis and maize
Researchers developed the first star-shaped polymer nanocarrier system capable of delivering microRNA — small genetic regulators — into plant cells, successfully testing it in Arabidopsis and maize. This nanoparticle-based delivery platform opens a new avenue for precise genetic modification in crops without traditional transformation methods.
How to Treat Melanoma? The Current Status of Innovative Nanotechnological Strategies and the Role of Minimally Invasive Approaches like PTT and PDT
This review summarizes advances in nanotechnology-based treatments for melanoma, including photothermal and photodynamic therapies using engineered nanoparticles as drug carriers and light absorbents. While nanoparticle-based therapies show promise for improving treatment outcomes, the environmental fate of these engineered nanomaterials remains a concern, as nanoparticles can behave similarly to microplastics when released into ecosystems.
Biomembrane-wrapped gene delivery nanoparticles for cancer therapy
This review examined biomembrane-wrapped nanoparticles as gene delivery vehicles for cancer therapy, highlighting how cell membrane coatings improve targeting, immune evasion, and therapeutic efficacy compared to conventional synthetic delivery systems.
Exploring Metal Nanoparticles Interaction with Cancer Cells
This paper is not relevant to microplastics research — it reviews the uses of metal nanoparticles in biomedical applications, particularly cancer treatment, and discusses their toxicity profiles.
Site-directed Conjugation of Single-Stranded DNA to Affinity Proteins: Quantifying the Importance of Conjugation Strategy
This study developed a new site-selective method for conjugating single-stranded DNA to affinity proteins for diagnostic and therapeutic applications. This is a biotechnology paper with no direct relevance to microplastics or environmental health.
Site-directed Conjugation of Single-Stranded DNA to Affinity Proteins: Quantifying the Importance of Conjugation Strategy
This study developed a new site-selective method for conjugating single-stranded DNA to affinity proteins for diagnostic and therapeutic applications. This is a biotechnology paper with no direct relevance to microplastics or environmental health.
Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin
This paper discusses the prevalence of micro- and nanoplastics and the health concerns they raise, particularly noting that nanoplastics are believed to be more toxic because they can pass through biological barriers. A key challenge is developing reliable detection methods for particles smaller than 1 micrometer.
DNA Nano‐Biomaterials Based Futuristic Technologies for Tissue Engineering and Regenerative Therapeutics
This review covers advances in DNA-based nanomaterials for tissue engineering and regenerative medicine, including drug delivery and wound healing. While not directly about microplastics, DNA nanotechnology could potentially be applied to detect or remediate nanoplastic contamination in biological tissues. The research represents a broader trend in nanoscale biomaterials that may intersect with microplastics research in the future.
Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy
Researchers reviewed how engineering the protein corona — the layer of proteins that coats nanoparticles in biological fluids — through modifications like PEGylation and protein pre-coating can improve nanoparticle targeting for cancer drug delivery by controlling how immune cells recognize and clear the particles.
The quest for nanoparticle-powered vaccines in cancer immunotherapy
This review explores how nanoparticles are being developed as cancer vaccine delivery systems to train the immune system to fight tumors more effectively. While focused on cancer immunotherapy rather than microplastics, the research highlights that understanding how nanoparticles interact with the immune system is crucial -- the same principles apply to understanding how nanoplastics may affect immune responses in the body.
Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy
Researchers reviewed how calcium-based nanomaterials can be used in cancer diagnosis and treatment, finding that deliberately flooding cancer cells with calcium ions — a process called "calcicoptosis" — can trigger cell death, opening a new avenue for targeted cancer therapy.
Tumorigenic and tumoricidal properties of exosomes in cancers; a forward look
This review explores how tiny cell-released vesicles called exosomes can either promote or fight cancer by transferring signaling molecules between cells. While not directly about microplastics, the research is relevant because nanoplastics are similar in size to exosomes and may interfere with these important cell communication pathways. Understanding how nanoscale particles affect cell signaling could help explain some of the biological effects of nanoplastic exposure.
DNA Damage prevention by the use of Computational Designed Microlpastics adsorbing Chemicals.
This computational study used molecular design to identify chemical structures capable of adsorbing microplastic-associated compounds that cause DNA damage, proposing designed molecules as potential protective agents against microplastic-driven genotoxicity and cancer risk.
Contribution of Cancer-Specific Protein Coronas to the Pro-Tumor Effects of Nanoplastics through Enhanced Cellular Interactions
Researchers investigated how nanoplastics interact with blood proteins to form a protein coating that changes how the particles behave around cancer cells. They found that this protein coating enhanced the uptake of nanoplastics by cancer cells and could promote tumor-related behaviors. The study raises important questions about whether nanoplastic exposure could influence cancer progression through these protein-mediated interactions.
Hydrogel-based nanoparticles: revolutionizing brain tumor treatment and paving the way for future innovations
Researchers reviewed how nanoparticles embedded in hydrogels — water-based gel materials — can serve as targeted drug delivery vehicles for brain tumors by crossing the blood-brain barrier, a major obstacle that blocks most medications from reaching the brain. These systems have shown improved survival rates in studies, and the review outlines remaining challenges around manufacturing, stability, and scaling up for clinical use.
Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity
This review examines how nanotechnology-based approaches can regulate lipid metabolism in tumor microenvironments to enhance anti-cancer immune responses, covering lipid nanoparticles, liposomes, and other delivery systems. The authors identify lipid metabolic reprogramming as a promising immunotherapy target and nanotechnology as a key enabler for delivering therapeutics that reshape tumor-associated metabolic pathways.