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61,005 resultsShowing papers similar to Melatonin Supplementation during In Vitro Maturation of Porcine Oocytes Alleviates Oxidative Stress and Endoplasmic Reticulum Stress Induced by Imidacloprid Exposure
ClearMelatonin Alleviates the Damage of Polystyrene Microplastics to Porcine Oocytes by Reducing Oxidative Stress and Mitochondrial Damage, and Regulating Autophagy and Apoptosis Levels
Researchers investigated whether the antioxidant melatonin could protect porcine oocytes from damage caused by polystyrene microplastics. The study found that microplastics at 30 micrograms per milliliter significantly impaired oocyte maturation, but melatonin treatment helped alleviate this damage by reducing oxidative stress, protecting mitochondrial function, and regulating autophagy and cell death pathways.
Melatonin mitigates polystyrene nanoplastics-induced impairment of oocyte maturation in mice
Researchers found that polystyrene nanoplastics impair egg cell maturation in mice by causing excessive oxidative stress, mitochondrial dysfunction, and disrupting the structural machinery needed for proper cell division. They then tested whether melatonin could counteract these effects and found that melatonin treatment significantly alleviated the damage by restoring mitochondrial function and reducing oxidative stress. The study suggests that melatonin may offer a protective strategy against nanoplastic-induced reproductive harm.
Melatonin alleviates oxidative stress damage in mouse testes induced by bisphenol A
Researchers investigated whether melatonin could alleviate oxidative stress damage caused by bisphenol A (BPA) exposure in mouse testicular tissue. The study found that melatonin treatment reduced BPA-induced oxidative damage and improved sperm quality indicators, suggesting a potential protective role against the reproductive effects of this common plastic-associated chemical.
Exogenous Melatonin Application Alleviates Microplastics and Cadmium‐Induced Phytotoxicity in Maize ( Zea mays L.) Plants: Insights From Physiological and Metabolomic Analyses
Researchers investigated whether exogenous melatonin could alleviate the combined phytotoxicity of microplastics and cadmium in maize plants. The study found that melatonin application reduced oxidative damage and improved plant growth under co-contamination stress, suggesting that melatonin may serve as a biostimulant to help crops cope with the increasingly common co-occurrence of microplastics and heavy metals in agricultural soils.
New Insight on the In Vitro Effects of Melatonin in Preserving Human Sperm Quality
Researchers found that melatonin protects human sperm quality against cadmium-induced oxidative stress in vitro, preserving motility, viability, DNA integrity, and mitochondrial function while reducing lipid peroxidation over 24 hours of exposure.
Melatonin reduces nanoplastic uptake, translocation, and toxicity in wheat
Researchers investigated whether melatonin could reduce the harmful effects of polystyrene nanoplastics on wheat plants. They found that melatonin application significantly decreased nanoplastic uptake by roots and their transport to shoots by regulating aquaporin gene expression and activating antioxidant defense systems. The study suggests that melatonin may serve as a protective agent to help mitigate nanoplastic toxicity in crops.
Melatonin Defends Against the Oxidative Stress by Preventing the Uptake of Nanoplastics and Activating the Antioxidant System in Paeonia ostii.
Scientists found that melatonin (a natural hormone) can protect plants from tiny plastic particles by blocking them from entering plant cells and reducing harmful damage inside the plant. This matters because these microscopic plastics are spreading everywhere in our environment and getting into our food chain. While this study only looked at plants, it suggests melatonin might help protect living things from plastic pollution - though more research is needed to know if this applies to humans.
Melatonin Alleviates Antimony Toxicity by Regulating the Antioxidant Response and Reducing Antimony Accumulation in Oryza sativa L.
Researchers investigated whether melatonin, a natural antioxidant compound, could help rice plants cope with toxic antimony contamination. They found that applying melatonin reduced antimony uptake, decreased oxidative damage, and improved rice growth under antimony stress conditions. The study suggests that melatonin treatments could be a practical strategy for growing rice in soils contaminated with heavy metals.
Tributyltin Oxide Exposure During in vitro Maturation Disrupts Oocyte Maturation and Subsequent Embryonic Developmental Competence in Pigs
Researchers found that tributyltin oxide (TBTO) exposure during in vitro maturation disrupts porcine oocyte maturation and impairs subsequent embryonic developmental competence, with effects mediated through mitochondrial dysfunction and oxidative stress pathways.
Melatonin-Mediated Abiotic Stress Tolerance in Plants
This review examines how melatonin, a molecule found in all living organisms, helps plants cope with environmental stresses like drought, extreme temperatures, salinity, and heavy metal contamination. Researchers found that melatonin works by neutralizing harmful reactive oxygen species and activating plant defense pathways. The study suggests that melatonin-based treatments could help improve crop resilience in the face of increasing environmental challenges, including soil pollution.
Reclaiming multi-contaminated soil: melatonin alleviates cadmium and microplastic toxicity to restore rice growth and yield
Researchers investigated whether melatonin could mitigate the combined toxicity of cadmium and microplastics in agricultural soils to restore rice growth and yield. The study found that melatonin treatment modulated plant physiological function, reduced cadmium uptake, and improved soil properties, offering a promising approach to help crops withstand multi-contaminant stress from both heavy metals and microplastics.
Melatonin Alleviates Intestinal Barrier Damaging Effects Induced by Polyethylene Microplastics in Albino Rats
Researchers found that polyethylene microplastics damaged the intestinal barrier in rats by causing inflammation, reducing protective mucus, and disrupting the tight junctions between gut cells. The damage was more severe at higher doses and included changes in gut bacteria composition. The study also found that melatonin treatment helped protect against these intestinal effects, suggesting potential avenues for reducing microplastic-related gut damage.
Induction of apoptosis, oxidative stress, hormonal, and histological alterations in the reproductive system of thiamethoxam-exposed female rats
Researchers studied the reproductive toxicity of the insecticide thiamethoxam in female rats over 30 days and found significant damage to the ovaries and uterus. The pesticide caused oxidative stress, hormonal imbalances, tissue damage, and increased markers of programmed cell death in reproductive organs. The study suggests that chronic exposure to this commonly used neonicotinoid insecticide may pose serious risks to female reproductive health.
Melatonin prevents the transgenerational toxicity of nanoplastics in zebrafish (Danio rerio)
This zebrafish study found that polystyrene nanoplastics caused harmful effects that passed from exposed parents to their offspring, including developmental problems and oxidative stress in the next generation. The hormone melatonin was able to protect against this transgenerational damage when given alongside the nanoplastic exposure. The findings suggest that nanoplastic exposure could affect not just the people exposed but potentially their children, and that antioxidants like melatonin might offer some protection.
Polystyrene Nanoparticles Cause Sex‐Specific Toxicity in Male Zebrafish, Which Can Be Mitigated by Melatonin
Researchers exposed adult zebrafish to polystyrene nanoparticles for 14 days and found significant reproductive toxicity that was more pronounced in males, including reduced gonadal size and disrupted hormone signaling along the hypothalamic-pituitary-gonadal axis. Co-treatment with melatonin largely reversed these harmful effects by protecting against oxidative damage. The study suggests that melatonin may offer a potential protective strategy against nanoplastic-induced reproductive harm.
Melatonin alleviates valproic acid-induced neural tube defects by modulating Src/PI3K/ERK signaling and oxidative stress
Researchers found that melatonin reduces neural tube defects caused by the antiepileptic drug valproic acid in a mouse model by modulating Src/PI3K/ERK signaling pathways, suggesting a potential protective strategy for pregnant women on this medication.
Melatonin enhances salt tolerance in sorghum by modulating photosynthetic performance, osmoregulation, antioxidant defense, and ion homeostasis
Exogenous melatonin application was found to enhance salt tolerance in sorghum by improving photosynthetic performance and modulating antioxidant responses during salt stress. The findings suggest melatonin could be a practical tool for improving crop resilience under salinity conditions.
Environmental microplastic accumulation exacerbates liver ischemia-reperfusion injury in rat: Protective effects of melatonin
Researchers found that environmental microplastic exposure worsened liver ischemia-reperfusion injury in rats, while melatonin treatment provided protective effects by reducing oxidative stress and inflammation caused by the combined insult.
Microplastics in ovarian function and ozone-based mitigation strategies: Emerging evidence and translational implications
This review synthesized emerging evidence that microplastics accumulate in human follicular fluid, oocytes, placenta, and semen, causing oxidative stress, mitochondrial dysfunction, and meiotic disruption in reproductive cells, and discussed ozone-based strategies as potential mitigation approaches.
Prenatal melatonin reprograms liver injury in male pups caused by maternal exposure to a high-fat diet and microplastics
Researchers investigated whether prenatal melatonin could protect against liver injury in rat pups caused by maternal exposure to both a high-fat diet and microplastics. The study found that combined high-fat diet and microplastic exposure increased liver fat accumulation, inflammation, and oxidative stress in offspring, but melatonin treatment significantly reduced these effects, suggesting its potential as a protective agent against microplastic-related liver damage during early development.
Involvement of Nitric Oxide and Melatonin Enhances Cadmium Resistance of Tomato Seedlings through Regulation of the Ascorbate–Glutathione Cycle and ROS Metabolism
Researchers found that melatonin and nitric oxide work together to enhance cadmium stress tolerance in tomato seedlings, with melatonin acting partly through nitric oxide signaling to reduce oxidative damage and support seedling growth under heavy metal stress.
Microplastics (MPs) exposure impairs porcine oocyte quality by triggering oxidative stress-directed DNA damage and apoptosis with metabolomic alterations
Researchers exposed pig egg cells (oocytes) to microplastics and found significant damage to their quality, including problems with cell division and chromosome structure. The microplastics disrupted important metabolic processes, leading to oxidative stress, DNA damage, and cell death. Since pig reproductive biology is similar to humans, these findings raise concerns that microplastic exposure could harm female fertility.
Exploring Oxidative Stress and Metabolic Dysregulation in Lung Tissues of Offspring Rats Exposed to Prenatal Polystyrene Microplastics: Effects of Melatonin Treatment
Researchers found that rat pups exposed to polystyrene microplastics before birth showed significant oxidative stress and metabolic disruption in their lung tissues. The prenatal exposure altered nucleic acid metabolism and amino acid profiles in the lungs of newborn pups. Encouragingly, treatment with melatonin significantly improved lung function and reduced tissue damage in the affected offspring.
Melatonin induces endoreduplication through oxidative DNA-damage triggering lateral root formation in onions
This study found that melatonin triggers lateral root formation in onions by inducing DNA damage and endoreduplication. Plant hormone research is relevant to microplastics because microplastics in soil can disrupt plant hormone signaling and root development in food crops.