Papers

61,005 results
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Article Tier 2

Syringodium isoetifolium Fosters an Antioxidant Defense System, Modulates Glycolytic Enzymes and Protects Membrane Integrity in DEN-induced Hepatocellular Carcinoma in Albino Wistar Rats

This paper is not about microplastics; it investigates the anti-cancer properties of Syringodium isoetifolium seagrass extract in a rat model of liver cancer, finding reduced tumor growth and restored liver tissue architecture.

2023 Indian Journal of Pharmaceutical Education and Research 1 citations
Article Tier 2

Protective Effect of Chlorella vulgaris and Spirulina platensis against ThioacetamideInduced Hepatorenal Toxicity in Male Rats

This paper is not directly about microplastics — it evaluates whether the microalgae Chlorella vulgaris and Spirulina platensis can protect against liver and kidney toxicity caused by thioacetamide in rats, finding significant protective effects via antioxidant mechanisms.

2023 Journal of Current Veterinary Research 2 citations
Article Tier 2

From Ocean to Medicine: Harnessing Seaweed’s Potential for Drug Development

This review explores how compounds derived from seaweed show promise for drug development, with properties including antioxidant, anti-inflammatory, and anticancer activity. While not directly about microplastics, marine-derived bioactive compounds could be relevant to addressing the inflammation and oxidative stress that microplastic exposure is known to cause in the body.

2024 International Journal of Molecular Sciences 42 citations
Article Tier 2

Screening of the Toxicity of Polystyrene Nano- and Microplastics Alone and in Combination with Benzo(a)pyrene in Brine Shrimp Larvae and Zebrafish Embryos

Researchers found that polystyrene nano- and microplastics alone showed minimal acute toxicity to brine shrimp and zebrafish embryos, but when combined with benzo(a)pyrene, the plastics altered the pollutant's bioavailability and toxic effects.

2022 Nanomaterials 34 citations
Article Tier 2

Potential toxicity of Schisandra chinensis to water environment: acute toxicity tests with water crustaceans

Aquatic toxicity tests with water crustaceans and algae assessed the environmental safety of Schisandra chinensis extracts used in health supplements, finding that bioactive secondary metabolites in this plant can cause ecotoxicological effects in aquatic organisms.

2023 Environmental Science and Pollution Research 5 citations
Article Tier 2

Determination of microplastics toxicity

Lab experiments tested the toxicity of polyethylene, polypropylene, and polystyrene microplastics on a green alga, a water flea, and zebrafish embryos, finding harmful effects at various concentrations. The study provides toxicological data supporting that microplastics pose real risks to aquatic organisms.

2020 Repository of Faculty of Chemical Engineering and Technology University of Zagreb
Article Tier 2

Acute and chronic effects of polystyrene microplastics on brine shrimp: First evidence highlighting the molecular mechanism through transcriptome analysis

Researchers investigated both acute and chronic toxicity of polystyrene microplastics on brine shrimp, using transcriptome analysis to uncover molecular mechanisms. While acute exposure did not significantly affect survival, chronic exposure led to concentration-dependent bioaccumulation and increased reactive oxygen species generation, with gene expression analysis revealing disrupted metabolic and stress response pathways.

2020 Journal of Hazardous Materials 176 citations
Article Tier 2

Rehashing Our Insight of Seaweeds as a Potential Source of Foods, Nutraceuticals, and Pharmaceuticals

This review summarizes research on seaweed as a source of beneficial compounds including antioxidants, anti-inflammatory agents, and other health-promoting substances. While not directly about microplastics, the research is relevant because seaweeds grow in marine environments increasingly contaminated with microplastics. Understanding the health benefits of seaweed also requires considering the potential risks of microplastic contamination in these marine food sources.

2023 Foods 38 citations
Article Tier 2

Microplastic toxicity in shrimp: From mechanistic pathways to ecological implications.

Researchers systematically reviewed 94 studies on microplastic toxicity in shrimp, mapping mechanistic pathways from particle characteristics to oxidative stress, immune dysfunction, neurotoxicity, and reproductive impairment across hepatopancreas, gills, gut, and gonad tissues, and identifying shrimp as effective bioindicators for aquatic microplastic risk assessment.

2026 Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
Article Tier 2

PLA Nanoplastics Accumulate but Do Not Cause Acute Toxicity to Marine Rotifers, Brine Shrimps, and Zebrafish Embryos

Researchers tested the acute toxicity and bioaccumulation of polylactic acid nanoplastics in three aquatic model organisms—marine rotifers, brine shrimps, and zebrafish embryos—finding that PLA nanoparticles accumulated but did not cause acute toxicity at the tested concentrations.

2025 Journal of Xenobiotics
Article Tier 2

[Effects of polystyrene microplastics (PS-MPs) on the growth, physiology, and biochemical characteristics of Hydrilla verticillata].

Researchers exposed an aquatic plant to increasing concentrations of polystyrene microplastics and found that high doses stunted plant height, reduced chlorophyll, and impaired photosynthesis. Submerged aquatic plants form the base of freshwater food webs, and their disruption by microplastic pollution could cascade through aquatic ecosystems.

2021 PubMed 11 citations
Article Tier 2

Acute and subacute repeated oral toxicity study of fragmented microplastics in Sprague-Dawley rats

Researchers conducted acute and subacute oral toxicity studies of weathered polypropylene microplastics in rats, using realistic fragmented particles to assess health effects from dietary microplastic exposure, providing toxicological data relevant to human food safety.

2021 Ecotoxicology and Environmental Safety 41 citations
Article Tier 2

Marine ecotoxicity of polystyrene microplastics, imidacloprid, and acyclovir: individual exposure in microalgae, rotifers and crustaceans

Researchers tested the individual toxicity of polystyrene microplastics, the pesticide imidacloprid, and the antiviral drug acyclovir on marine microalgae, rotifers, and crustaceans. All three pollutants caused dose-dependent toxicity, with crustaceans being most sensitive to polystyrene MPs and rotifers most affected by pharmaceutical exposure.

2025 Marine Environmental Research
Article Tier 2

Saving the pharmacy of the sea: How does global change affect species with bioactive potential in the Mediterranean?

This study examined how human activities — including pollution, fishing, and climate change — threaten Mediterranean marine species that produce potentially useful bioactive compounds. Microplastic contamination is among the stressors affecting these species and their ability to produce molecules of pharmaceutical interest.

2020 Mètode Revista de difusió de la investigació 1 citations
Article Tier 2

Biological toxicity of sulfamethoxazole in aquatic ecosystem on adult zebrafish (Danio rerio)

Not relevant to microplastics — this study examines how the antibiotic sulfamethoxazole affects zebrafish health, finding that chronic exposure causes liver and gill oxidative damage and disrupts gut bacteria, with no focus on plastic pollution.

2023 Research Square (Research Square)
Article Tier 2

Ecological Risks of Microplastic Toxicity on Biota and Plants

This review examines the ecological risks of microplastic toxicity to a wide range of organisms including plants, invertebrates, fish, and soil biota, synthesizing dose-response data and identifying the most sensitive species and exposure pathways across terrestrial and aquatic ecosystems.

2025
Article Tier 2

A review of microplastic impacts on seagrasses, epiphytes, and associated sediment communities

This review synthesizes research on microplastic accumulation in seagrass ecosystems, examining effects on seagrass plants, epiphytic communities, and associated sediment biota. The authors identify seagrass meadows as both sinks for microplastics and potentially sensitive ecosystems where plastic contamination may disrupt complex ecological relationships.

2022 Environmental Pollution 62 citations
Article Tier 2

Early evidence of the impacts of microplastic and nanoplastic pollution on the growth and physiology of the seagrass Cymodocea nodosa

Researchers explored the effects of polystyrene micro- and nanoplastics on the seagrass Cymodocea nodosa, which provides important ecosystem services in marine environments. The study found evidence of impacts on seagrass growth and physiology from plastic particle exposure. The findings are significant because seagrass meadows are particularly prone to accumulating plastic debris and are already declining globally due to other anthropogenic stressors.

2022 The Science of The Total Environment 65 citations
Article Tier 2

Unraveling the toxic mechanisms of microplastics in aquatic ecosystem: A case study on Vallisneria natans and Myriophyllum verticillatum

Researchers exposed two submerged aquatic plant species (Vallisneria natans and Myriophyllum verticillatum) to PVC, polystyrene, and polyethylene microplastics at three concentrations, finding that all three types significantly inhibited photosynthesis and growth and triggered oxidative stress, with effects varying by plastic type and plant species.

2025 Environmental Pollution 3 citations
Article Tier 2

Toxicological review of micro- and nano-plastics in aquatic environments: Risks to ecosystems, food web dynamics and human health.

This review synthesized evidence on the toxicological effects of micro- and nanoplastics in aquatic ecosystems, covering risks to individual organisms, disruptions to food web dynamics, and pathways through which plastic exposure poses risks to human health via seafood consumption.

2024 Ecotoxicology and environmental safety
Article Tier 2

Metformin and guanylurea reduce survival, but have limited sublethal effects in larval zebrafish ( Danio rerio )

This paper is not directly about microplastics; it tests the effects of the diabetes drug metformin and its breakdown product guanylurea on larval zebrafish, finding reduced survival at high concentrations and raising concerns about pharmaceutical pollution in freshwater ecosystems.

2023
Article Tier 2

Toxicity of microplastics in the marine environment.

This review chapter provides a broad and updated overview of microplastic ecotoxicology in marine environments, covering effects from the biochemical level through population and ecosystem scales. Evidence reviewed demonstrates that microplastics can act as physical hazards and chemical vectors affecting marine biodiversity across multiple trophic levels.

2019 CABI eBooks 4 citations
Article Tier 2

Ekotoksičnost nesteroidnih protuupalnih lijekova na vodene organizme

This Croatian review examines the ecotoxicological effects of non-steroidal anti-inflammatory drugs (NSAIDs) on aquatic organisms. NSAIDs are widely detected in wastewater and surface waters, where they can harm fish, invertebrates, and algae even at low concentrations. Since microplastics can absorb and concentrate NSAIDs, their joint presence in water may amplify toxic effects on aquatic life.

2023 Kemija u industriji
Article Tier 2

Toxicity Test of Strong Drug Using the BSLT (Brine Shrimp Lethality Test) Method

Researchers used the brine shrimp lethality test method to assess the acute toxicity of commonly used pharmaceutical drugs. The study evaluated the cytotoxic potential of these compounds as a pre-screening tool, providing data on lethal concentration values that indicate the relative toxicity of different drug compounds to the model organism Artemia salina.

2023 International Journal of Health Sciences and Research 15 citations