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Ekotoksičnost nesteroidnih protuupalnih lijekova na vodene organizme
Summary
This Croatian review examines the ecotoxicological effects of non-steroidal anti-inflammatory drugs (NSAIDs) on aquatic organisms. NSAIDs are widely detected in wastewater and surface waters, where they can harm fish, invertebrates, and algae even at low concentrations. Since microplastics can absorb and concentrate NSAIDs, their joint presence in water may amplify toxic effects on aquatic life.
U današnjem modernom svijetu teško je zamisliti život bez uporabe nesteroidnih protuupalnih lijekova. Naime, zbog lake dostupnosti svjedočimo njihovoj sve većoj prisutnosti u svim sastavnicama okoliša, gdje najčešće završavaju zbog nepropisnog odlaganja ili putem otpadnih voda. Stoga je važno napomenuti da se nesteroidni protuupalni lijekovi najčešće mogu naći kao sastavni dio otpadnih voda porijeklom iz farmaceutskih industrija i bolnica te komunalnih otpadnih voda. Znanstvenici su postali svjesni da ti lijekovi u posljednjih nekoliko desetljeća predstavljaju veliku opasnost jer, osim što onečišćuju sve sastavnice okoliša, uzrokuju i negativne posljedice i na organizme prisutne u okolišu te se sve više vremena posvećuje provođenju testova ekotoksičnosti. Testovi ekotoksičnosti najbolje su rješenje za praćenje štetnih učinaka pojedinih tvari ili njihovih smjesa na organizme, pri čemu se može predvidjeti štetan učinak i na čovjeka. U ovom radu dan je pregled dosadašnjih istraživanja vezanih uz nesteroidne protuupalne lijekove te njihove uloge u hranidbenom lancu. Dodatno, dan je pregled više vrsta lijekova poput ibuprofena, diklofenaka i ketoprofena te opisan njihov učinak na određene organizme poput Daphnia magna, Danio rerio, Tinca tinca i Navicula sp.
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