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Papers
61,005 resultsShowing papers similar to In vivo evaluation of the neurogenotoxic effects of exposure to validamycin A in neuroblasts of Drosophila melanogaster larval brain
ClearDrosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compounds
This review assessed Drosophila melanogaster as a model organism for studying the neurotoxic mechanisms of environmental contaminants, highlighting its genetic similarity to mammals and well-characterized neural architecture. The authors catalogued how different categories of neurotoxicants including pesticides, heavy metals, and plastic-associated chemicals affect Drosophila behavior and brain development.
The effects of microplastics and nanoplastics upon history, policies, and Drosophila melanogaster
This study examined the effects of microplastics and nanoplastics on the fruit fly Drosophila melanogaster, finding that dietary exposure to these pervasive environmental contaminants causes measurable biological harm and making the case for stronger regulatory policies.
Drosophila melanogaster as a tractable eco-environmental model to unravel the toxicity of micro- and nanoplastics
This review summarizes research using fruit flies as a model to study how micro- and nanoplastics harm living organisms. Studies show these tiny plastic particles cause oxidative stress, inflammation, DNA damage, and reproductive problems in flies, with males being more vulnerable than females -- findings that may help us understand similar risks in humans.
Adverse biological effects of ingested polystyrene microplastics using Drosophila melanogaster as a model in vivo organism
Researchers used fruit flies as an in vivo model to study the biological effects of ingesting polystyrene microplastics at three different sizes. Exposure caused significant morphological defects, impaired climbing behavior, and genotoxic effects as shown by a somatic mutation test. The findings suggest that polystyrene microplastics may induce genetic damage primarily through somatic recombination, raising concerns about their potential biological impact on living organisms.
Assessing genotoxic effects of plastic leachates in Drosophila melanogaster
Researchers exposed fruit flies to chemicals leached from conventional and oxodegradable polypropylene and polyethylene plastics and found that while the flies appeared healthy on the surface, their DNA suffered chromosomal damage and genetic instability in neural tissue. These findings raise concern that plastic leachates — chemicals that seep out of plastic waste — may carry hidden genetic risks for organisms living in contaminated soil.
Plastic Fly: What Drosophila melanogaster Can Tell Us about the Biological Effects and the Carcinogenic Potential of Nanopolystyrene
Researchers used fruit flies as a model organism to investigate whether polystyrene nanoplastics can cause genetic damage and promote tumor growth. They found that nanoplastic exposure led to DNA damage and increased tumor formation in the flies, with effects worsening at higher concentrations. The study suggests that nanoplastics commonly found in food packaging may carry cancer-promoting potential that warrants further investigation.
Neuromuscular, retinal, and reproductive impact of low-dose polystyrene microplastics on Drosophila
Researchers found that even low doses of polystyrene microplastics impaired neuromuscular signaling, altered retinal function, and reduced reproductive rates in fruit flies, with gene expression changes in key signaling pathways underlying these effects.
Abamectin Causes Neurotoxicity in Zebrafish Embryos
This study found that abamectin, a widely used agricultural pesticide, caused brain damage and nerve cell death in developing zebrafish embryos through oxidative stress. While not about microplastics, the research is relevant because microplastics can absorb and transport pesticides like abamectin through water systems, potentially delivering concentrated doses to aquatic organisms. Understanding pesticide neurotoxicity helps explain how chemical-laden microplastics could harm both wildlife and human nervous system development.
Transgenerational effects on development following microplastic exposure in Drosophila melanogaster
Researchers fed Drosophila melanogaster flies plastic-supplemented food and found that while treated flies showed changes in fertility and sex ratio, their unexposed offspring had shorter larval development and reduced adult size, demonstrating transgenerational developmental effects from parental microplastic exposure.
Molecular cloning and transformation of cyclodiene resistance in Drosophila : An invertebrate γ-amino-butyric acid subtype A receptor locus
The abstract for this entry describes growing global concerns about micro- and nanoplastics and the need for better analytical methods. The title refers to a molecular biology study on insecticide resistance in Drosophila, indicating a database mismatch.
Hazard assessment of ingested polystyrene nanoplastics in Drosophila larvae
Researchers assessed the hazard of ingested polystyrene nanoplastics in Drosophila larvae, examining effects on gut morphology, oxidative stress, and development to characterize toxicological risks of nanoplastic exposure in a model invertebrate organism.
Drosophila melanogaster as a dynamic in vivo model organism reveals the hidden effects of interactions between microplastic/nanoplastic and heavy metals
Researchers used Drosophila melanogaster as an in vivo model to reveal that interactions between micro/nanoplastics and heavy metals produce combined toxic effects that are more severe than exposure to either contaminant alone.
Peer Review #1 of "Transgenerational effects on development following microplastic exposure in Drosophila melanogaster (v0.1)"
This is a peer review document evaluating a study on transgenerational effects of microplastic exposure in Drosophila fruit flies. The underlying research examined whether microplastics affect fly life history traits and immune responses in ways that persist across generations.
No evidence for behavioral or physiological effects of nanoplastics ingestion in the fruit fly Drosophila melanogaster
Researchers exposed Drosophila melanogaster to low and high concentrations of nanoplastics (1 µg/g and 1 mg/g) across several generations and measured emergence rate, mitochondrial activity, metabolism, body mass, and locomotion. No significant behavioral or physiological effects were detected, suggesting Drosophila may be less sensitive to nanoplastics than aquatic species.
Neuronal damage induced by nanopolystyrene particles in nematodeCaenorhabditis elegans
C. elegans nematodes were chronically exposed to nanopolystyrene particles and found to develop neuronal damage affecting both development and function of the nervous system after long-term exposure at environmentally relevant concentrations. The study provides early evidence that nanoplastics can cause neurological harm in an animal model, raising questions about potential neurotoxicity in other species.
Deciphering the Neurotoxic Burden of Micro- and Nanoplastics: From Multi-model Experimental Evidence to Therapeutic Innovation
This review summarizes research on how micro- and nanoplastics damage the brain and nervous system, covering evidence from cell studies, animal experiments, and clinical observations. Plastic particles can cross the blood-brain barrier, disrupt the gut-brain connection, cause oxidative stress, and trigger inflammation that leads to memory problems and cognitive decline. The review also discusses potential treatment strategies, making it a useful resource for understanding the brain health risks of plastic exposure.
Analysis of the Acute Toxicity Effects of Bifenthrin on Chinese Giant Salamander (Andrias davidianus) Larvae
This is a duplicate of paper 37978 — it is not a microplastics study; it examines the toxic effects of the insecticide bifenthrin on Chinese giant salamander larvae, finding oxidative stress, liver damage, and DNA damage at environmentally relevant concentrations.
Exploring the Neurotoxic Potential of LDPE Microplastics: Evidence in Vitro and in Vivo Assessment
This study assessed the neurotoxic potential of LDPE microplastics in both in vitro neural cell models and in vivo animal exposure experiments, finding evidence of neuroinflammation, oxidative stress, and disrupted neurochemistry at environmentally relevant concentrations.
Polystyrene microplastics alter physiological parameters in the Drosophila model
Researchers investigated the effects of polystyrene micro- and nanoplastics on fruit flies (Drosophila melanogaster) and found dose- and size-dependent toxicity at both larval and adult stages. Exposure caused significant behavioral impairments, elevated markers of cellular stress, and activated key stress response genes, indicating that polystyrene microplastics induce oxidative stress and cellular damage.
Size-dependent and sex-specific negative effects of micro- and nano-sized polystyrene particles in the terrestrial invertebrate model Drosophila melanogaster
Fruit flies exposed to low doses of polystyrene micro and nanoparticles for 28 days showed tissue damage in their gut, ovaries, and testes, with smaller particles causing more harm. The plastics triggered oxidative stress and cell death in gut tissue, though reproduction was not significantly affected at these doses. This study, using a well-established model organism, suggests that even low-level, long-term exposure to tiny plastic particles can damage internal organs, with potential implications for other species including humans.
Analysis of the Acute Toxicity Effects of Bifenthrin on Chinese Giant Salamander (Andrias davidianus) Larvae
This is not a microplastics study; it investigates the acute toxic effects of the insecticide bifenthrin on Chinese giant salamander larvae, finding oxidative stress, liver inflammation, and DNA damage at tested concentrations.
Genotoxicity and Genomic Instability Induced by Micro- and Nanoplastics: A Comprehensive Multi-Taxa Mechanistic Review.
This review of existing research found that tiny plastic particles (microplastics and nanoplastics) can damage DNA in many different living things, from fish to human cells. The plastic particles cause this damage by creating harmful molecules called free radicals, disrupting the body's ability to repair DNA, and triggering inflammation. These findings suggest that the growing amount of plastic pollution in our environment could pose serious health risks to humans and wildlife.
Effects of Microplastics and Nanoplastics Exposure on Neurogenesis. Are Thymidine Analogues a Good Option to Study Such Effects?
This review covers the neurotoxic effects of microplastics and nanoplastics, examining how these particles enter the nervous system through inhalation, ingestion, and skin contact, and discusses whether thymidine analogues used to track cell division are appropriate tools for studying plastic-induced neurogenesis disruption.
Study on Chemically-induced Diet Alteration of Drosophila Melanogaster
This study used Drosophila melanogaster as an in vivo model to assess how chemical compounds — including plastic-associated chemicals — alter feeding behavior and development, evaluating the fruit fly's diet alteration response as a sensitive toxicity endpoint for environmental contaminant screening.