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61,005 resultsShowing papers similar to The Other Side of Plastics: Bioplastic-Based Nanoparticles for Drug Delivery Systems in the Brain
ClearNeurotoxicity of nanoplastics: A review
This review examines the growing body of evidence on how nanoplastics may affect the nervous system. Researchers summarized findings showing that nanoplastics can cross biological barriers, accumulate in brain tissue, and trigger oxidative stress and inflammation in nerve cells. The evidence indicates that nanoplastic exposure may contribute to neurotoxic effects, though more research is needed to fully understand the risks to human brain health.
Brain under siege: the role of micro and nanoplastics in neuroinflammation and oxidative stress
This review examines emerging evidence that micro- and nanoplastics can cross the blood-brain barrier and accumulate in nervous tissue, potentially triggering neuroinflammation and oxidative stress. Researchers summarized findings showing these particles may act as neurotoxicants that contribute to synaptic dysfunction and pathological changes in brain cells. The study highlights the need for further research into how chronic plastic particle exposure may affect central nervous system health over time.
Biodegradable Nanoplastic: a Tool for Drug Delivery and Environmental Challenge
This review discusses the dual nature of biodegradable nanoplastics — their promise as targeted drug delivery vehicles due to their controllable surface chemistry, versus the environmental concern of uncontrolled nanoplastic accumulation from biodegradable polymer degradation in ecosystems.
The neurotoxic threat of micro- and nanoplastics: evidence from In Vitro and In Vivo models
This systematic review examined 26 studies showing that micro- and nanoplastics can cross into the brain, damage neurons, and trigger inflammation in lab and animal models. These findings raise concerns that long-term plastic exposure could contribute to neurological problems in humans, though more research is needed.
Nanomaterials in Drug Delivery: Strengths and Opportunities in Medicine
This review covers how nanomaterials are being used to improve drug delivery for treating cancer and infections, offering better targeted therapy with fewer side effects. While not directly about microplastics, the research on how nanoparticles interact with human tissues provides insight into how similarly sized nanoplastics might behave once inside the body.
A perspective on the potential impact of microplastics and nanoplastics on the human central nervous system
This paper discusses evidence that micro- and nanoplastics may be able to cross the blood-brain barrier, the protective layer that normally keeps harmful substances out of the brain. If confirmed in humans, this could mean plastic particles contribute to neurodegenerative diseases, though more research is needed to understand the extent of this risk.
Neurotoxicity Following Exposure to Micro and Nanoplastics
This review explores how micro and nanoplastics can reach the brain after being swallowed or inhaled, and what neurotoxic effects they may cause. Research shows these tiny particles can cross the blood-brain barrier, similar to metal nanoparticles, and potentially damage brain cells. While the full extent of brain harm from plastic particles is still being studied, early findings raise concerns about long-term neurological effects from everyday exposure.
Nano- and Microplastics in the Brain: An Emerging Threat to Neural Health
This review summarizes evidence that nano- and microplastics can cross the blood-brain barrier and accumulate in brain tissue, where they trigger oxidative stress, inflammation, and protein clumping linked to diseases like Alzheimer's and Parkinson's. The findings suggest that plastic particles may also interfere with the brain's ability to heal from injury, though long-term human studies are still lacking.
Overall effects of microplastics on brain
This review synthesizes research on how micro- and nanoplastics affect the brain, finding evidence that these particles can cross critical biological barriers including the blood-brain barrier and placenta to reach the central nervous system. Researchers found that once in the brain, microplastics may trigger oxidative stress, inflammation, and disruption of neurotransmitter systems. The study suggests that microplastic exposure represents an emerging concern for neurological health, though more research is needed to fully characterize the risks.
Deciphering the Neurotoxic Burden of Micro- and Nanoplastics: From Multi-model Experimental Evidence to Therapeutic Innovation
This review summarizes research on how micro- and nanoplastics damage the brain and nervous system, covering evidence from cell studies, animal experiments, and clinical observations. Plastic particles can cross the blood-brain barrier, disrupt the gut-brain connection, cause oxidative stress, and trigger inflammation that leads to memory problems and cognitive decline. The review also discusses potential treatment strategies, making it a useful resource for understanding the brain health risks of plastic exposure.
Micro-nanoplastics in the central nervous system: Evidence, mechanisms and perspectives
This review examines evidence that micro- and nanoplastics can cross the blood-brain barrier and cause neurotoxicity through oxidative stress, neuroinflammation, and disruption of neurotransmitter signaling. While clinical studies have confirmed the presence of plastic particles in human brain tissue and cerebrospinal fluid, the authors note that methodological limitations and inconsistent quality controls currently prevent establishing a definitive causal link to neurological conditions.
Neurotoxicities induced by micro/nanoplastics: A review focusing on the risks of neurological diseases
This review summarizes evidence that micro- and nanoplastics can reach the brain through the bloodstream and nerve pathways, where they trigger oxidative stress, inflammation, and cell damage that may contribute to neurodegenerative diseases. The particles are found in air, water, soil, and food, meaning humans are constantly exposed through breathing, eating, and skin contact, making brain effects a serious long-term concern.
Assessing the Impact of Microplastics on Brain Chemistry: The Need for a Comprehensive Policy Framework to Mitigate Toxicity
This review examines the growing evidence that microplastics can cross biological barriers, accumulate in brain tissue, and affect neurological function. Researchers found that microplastic exposure has been linked to neurotoxicity, oxidative stress, and inflammation in the brain, with potential implications for neurotransmitter systems and cognitive function. The study calls for comprehensive regulatory measures to limit microplastic pollution and further research into the long-term neurological health effects.
Mechanisms of micro- and nanoplastics on blood-brain barrier crossing and neurotoxicity: Current evidence and future perspectives
This review examines evidence that micro- and nanoplastics can cross the blood-brain barrier, the protective shield around the brain, through multiple pathways including disrupting the barrier's tight junctions and being transported inside cells. Once in the brain, these particles may cause damage through oxidative stress, inflammation, mitochondrial dysfunction, and disrupted iron metabolism, with effects worsened when plastics carry other pollutants like heavy metals.
Unveiling the toxicity of micro-nanoplastics: A systematic exploration of understanding environmental and health implications
This review summarizes what is known about the toxicity of micro- and nanoplastics, noting they can cross critical barriers in the body including the blood-brain barrier. Studies in lab animals show these particles can cause DNA damage, oxidative stress, and cell death, with potential effects on the brain, heart, lungs, and skin, underscoring the need for more real-world human studies.
A systematic review of the potential neurotoxicity of micro-and nanoplastics: the known and unknown
This systematic review summarizes 234 research studies on how micro- and nanoplastics may harm the brain and nervous system. Evidence from animal and lab studies suggests these particles can reach the brain, potentially through the nose or by crossing the blood-brain barrier, and may cause inflammation and damage to nerve cells.
A systematic review of the potential neurotoxicity of micro-and nanoplastics: the known and unknown
This critical review of 234 studies found that micro- and nanoplastics can reach the brain via olfactory translocation or by crossing the blood-brain barrier, where they may cause neuroinflammation, oxidative damage, and behavioral changes in animal models. The evidence raises significant concerns about potential neurotoxic effects of chronic microplastic exposure in humans, though major knowledge gaps remain.
Crossing barriers – tracking micro- and nanoplastic pathways into the human brain
Researchers tracked potential pathways by which micro- and nanoplastics may enter the human brain, examining both in vitro cell models and post-mortem brain tissue. They found that human monocytes rapidly internalized polystyrene particles into endocytic vesicles and mitochondria, and detected plastic particles in brain tissue samples, providing evidence that nanoplastics may be capable of crossing brain barriers.
From the Environment to Molecular Interactions of Nanoplastics: Unraveling the Neurotoxic Impacts and the Implications in Neurodegenerative Processes
This review examines how nanoplastics can cross the blood-brain barrier and potentially contribute to brain damage and neurodegenerative diseases like Alzheimer's and Parkinson's. Nanoplastics have been found in food, water, and air, and once they reach the brain they can trigger inflammation, oxidative stress, and protein misfolding. The review calls for more realistic lab studies and better detection methods to understand the true scope of nanoplastic effects on brain health.
A systematic review of the potential neurotoxicity of micro-and nanoplastics: the known and unknown
This systematic review summarizes 234 research studies on how micro- and nanoplastics may harm the brain and nervous system. Evidence from animal and lab studies suggests these particles can reach the brain through the nose or by crossing the blood-brain barrier, potentially causing inflammation, oxidative stress, and nerve cell damage.
The effects of micro- and nanoplastics on the central nervous system: A new threat to humanity?
This review summarizes growing evidence that micro- and nanoplastics can cross the blood-brain barrier and damage the central nervous system through inflammation, oxidative stress, and disruption of brain chemicals. The authors note that microplastic exposure has been linked to memory and behavior changes in animals and may contribute to neurodegenerative diseases like Parkinson's, though direct human evidence is still limited.
Toxicity and Accumulation of Nanoplastics Materials: A Review of Experimental Evidence Across Biological Systems
This systematic review of studies from 2010 to 2025 found that nanoplastics can penetrate biological barriers and accumulate in tissues across many organisms. Their tiny size makes them especially concerning because they can enter cells, cause oxidative stress and inflammation, and potentially affect organ function in ways that larger plastic particles cannot.
PLASTAMINATION: Outcomes on the Central Nervous System and Reproduction.
This review assessed evidence for neurotoxic and reproductive effects of both biodegradable and conventional micro- and nanoplastics, finding that plastic particles and their chemical additives can cross the blood-brain barrier and disrupt hormone systems, with concerning implications for nervous system and reproductive health.
The plastic brain: neurotoxicity of micro- and nanoplastics
This review examines the emerging evidence that micro- and nanoplastics can reach the brain in both aquatic animals and mammals, potentially causing neurotoxic effects. Researchers found that exposure to these particles induces oxidative stress, inhibits key enzymes involved in nerve signaling, and alters neurotransmitter levels, which may contribute to behavioral changes. The study highlights that systematic research comparing different particle types, sizes, and exposure conditions is urgently needed to understand the neurological risks.