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Papers
61,005 resultsShowing papers similar to The Anti-Oxidative, Anti-Inflammatory, Anti-Apoptotic, and Anti-Necroptotic Role of Zinc in COVID-19 and Sepsis
ClearThe Effect of Dietary Supplementation with Zinc Amino Acids on Immunity, Antioxidant Capacity, and Gut Microbiota Composition in Calves
Researchers found that dietary supplementation with zinc amino acids improved immunity, antioxidant capacity, and beneficial gut microbiota composition in calves, with effects varying by zinc concentration in the diet.
Effectiveness of N-Acetylcysteine on Zinc oxide Nanoparticles-Induced Cardiotoxicity in Adult Albino Rats
Researchers exposed adult albino rats to zinc oxide nanoparticles orally and investigated whether N-acetylcysteine — a free radical scavenger — could protect against ZnO nanoparticle-induced cardiotoxicity, measuring oxidative stress markers, histopathological changes, and cardiac enzyme levels to evaluate the mechanistic basis and protective efficacy of NAC treatment.
Integration of Physiological, Transcriptomic and Metabolomic Reveals Molecular Mechanism of Paraisaria dubia Response to Zn2+ Stress
This paper is not about microplastics; it investigates how the entomopathogenic fungus Paraisaria dubia tolerates and removes zinc from contaminated media, relevant to heavy metal bioremediation.
Assessing the Dual Impact of Zinc Oxide Nanoparticles on Living Organisms: Beneficial and Noxious Effects
This review examines the dual effects of zinc oxide nanoparticles in animal agriculture, aquaculture, and veterinary medicine, noting both beneficial antimicrobial properties and potential toxicity concerns. Researchers found that while these nanoparticles show promise against multi-drug-resistant bacteria, their environmental accumulation raises questions about ecosystem and health impacts. The study highlights the need to balance the utility of nanoparticle technologies against their potential risks as environmental contaminants.
The Influence of Supplementation with Zinc in Micro and Nano Forms on the Metabolism of Fatty Acids in Livers of Rats with Breast Cancer.
This study investigated the effects of zinc nano- and microparticles as dietary supplements on fatty acid metabolism in rats with breast cancer. This pharmacology study focuses on zinc supplementation and cancer biochemistry, with no direct relevance to environmental microplastics.
Protective Effects of Theaflavins and Epigallocatechin Gallate against ZnO-NP-Induced Cell Apoptosis In Vitro
Researchers evaluated whether theaflavins (TFs) and epigallocatechin gallate (EGCG) could protect rat tracheal epithelial cells against zinc oxide nanoparticle (ZnO-NP)-induced cytotoxicity, exposing cells to 100 micrograms per liter ZnO-NPs followed by varying concentrations of the tea polyphenols and measuring oxidative stress, inflammation, and apoptosis markers. Both compounds showed protective effects against ZnO-NP-induced cell damage in a dose-dependent manner.
Evaluating the Effectiveness of Vitamins E and C in Mitigating the Toxic Effects of Zinc Oxide Bulk and Nanoparticles on Fish: A Review
This paper is not relevant to microplastics — it is a review of how vitamins E and C can reduce the toxic effects of zinc oxide nanoparticles on fish in aquatic environments.
Exploring the Toxic Effects of ZEA on IPEC-J2 Cells from the Inflammatory Response and Apoptosis
Researchers explored how the fungal toxin zearalenone (ZEA) damages porcine small intestinal epithelial cells through oxidative stress, inflammation, and programmed cell death. The study found that ZEA exposure caused severe oxidative stress, significantly reduced antioxidant enzyme levels, and triggered cell death pathways, demonstrating its toxic effects on intestinal health.
Enhancing spinach growth and soil microbial health under sulfadiazine and polypropylene exposure through zinc fortification
Researchers found that zinc oxide nanoparticles can effectively reduce the toxic effects of antibiotics and polypropylene microplastics on spinach plants grown in contaminated soil. The zinc treatment lowered oxidative stress markers by 18-28% while boosting the activity of protective enzymes in roots and shoots. The study suggests that zinc supplementation could be a practical strategy for improving crop health in soils polluted with microplastics and pharmaceutical residues.
New regulatory mechanisms of polystyrene nanoplastics on the ecological risk of zinc: Cellular oxidative injury and molecular toxicity mechanisms in soil sentinel organisms (Eisenia fetida)
Researchers investigated how nanoplastics and zinc interact to affect earthworm cells and a key antioxidant defense enzyme. While nanoplastics alone had minimal effect, combining them with zinc dramatically increased cell death beyond what zinc caused on its own, and molecular modeling showed nanoplastics can physically bind to and potentially block the antioxidant enzyme. The findings suggest that nanoplastics may worsen the toxicity of heavy metals in soil by interfering with organisms' natural defense mechanisms.
Application of Metal Nanoparticles for Production of Self-Sterilizing Coatings
This review examined metal nanoparticles — including silver, gold, copper, and zinc oxide — used in self-sterilizing coatings, summarizing their antimicrobial mechanisms, synthesis methods, and documented activity against pathogenic bacteria, viruses, and fungi for packaging and surface applications.
Effects of Zn Exposure on Populus simonii Seedling Growth and Its Resistance to Leaf Rust
Zinc stress in Populus simonii seedlings significantly inhibited growth and reduced antioxidant and defense enzyme activities, with increasing Zn concentrations decreasing chemical defenses and increasing leaf rust disease incidence, suggesting heavy metal stress compromises woody plant disease resistance.
Characterization of Nanoparticles in Antimicrobial Coatings for Medical Applications—A Review
This review covers the different types of nanoparticles used in antimicrobial coatings for medical and dental devices, including silver, copper, and zinc-based materials. Researchers discuss the methods used to characterize these coatings and ensure they are effective against drug-resistant microorganisms. The study emphasizes the importance of thorough testing to confirm the safety and performance of these coatings in healthcare settings.
Gasdermins in sepsis
This review covered the roles of gasdermin proteins in sepsis, examining how these pore-forming executors drive inflammatory cell death and cytokine release during the dynamic inflammatory and immune responses across different stages of the disease.
Effect of zinc oxide nanoparticle types on the structural, mechanical and antibacterial properties of carrageenan-based composite films
Researchers synthesized zinc oxide nanoparticles from three different zinc salts and incorporated them into carrageenan composite films, evaluating how synthesis precursor affects the structural, mechanical, and antibacterial properties of the resulting biopolymer composites. The study identified which ZnONP synthesis route produces nanoparticles with the most favorable properties for food packaging applications.
Silver nanoparticles in diabetes mellitus: therapeutic potential and mechanistic insights
Researchers review evidence that silver nanoparticles — particles smaller than 100 nanometers with antimicrobial and antioxidant properties — may help manage diabetes by improving insulin sensitivity, reducing inflammation, and protecting the insulin-producing cells of the pancreas. While early studies show therapeutic promise, the authors caution that long-term safety data are still needed before silver nanoparticles can be considered for clinical use.
Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage through endothelial cell pyroptosis inhibition
Researchers investigated how the compound Huperzine A affects brain damage following spontaneous subarachnoid hemorrhage in rats. They found that the treatment reduced blood-brain barrier damage and brain swelling by blocking a type of inflammatory cell death in blood vessel cells. The study suggests that Huperzine A may offer protective benefits for brain health after hemorrhagic stroke through its anti-inflammatory and antioxidant properties.
Protective role of nano-selenium on Gymnocypris przewalskii under saline–alkaline stress: a comprehensive analysis of transcriptomics and metabolomics
Scientists studied a type of fish that lives in very salty, harsh water and found that tiny selenium particles helped protect the fish from stress and damage. The selenium particles worked by changing how the fish's genes and body chemistry responded to the difficult environment. While this study was done in fish, selenium is an important nutrient for humans too, and this research could help scientists better understand how selenium protects our bodies from environmental stress and damage.
Potential application of traditional Chinese medicine in cerebral ischemia—Focusing on ferroptosis
This review examined evidence for traditional Chinese medicine compounds in treating cerebral ischemia by targeting ferroptosis, an iron-dependent form of regulated cell death. Multiple TCM-derived compounds including flavonoids and alkaloids showed neuroprotective effects through ferroptosis pathway inhibition in experimental ischemia models.
Advances in the regulatory mechanisms of mTOR in necroptosis
This review explores how the mTOR signaling pathway regulates necroptosis, a form of programmed cell death distinct from apoptosis. Researchers describe multiple mechanisms through which mTOR influences cell death, including direct regulation of key necroptosis proteins, indirect effects through autophagy, and modulation of reactive oxygen species. The study highlights that mTOR can both promote and inhibit necroptosis depending on the context, making it a complex but promising therapeutic target.
Selenium-containing polysaccharide from Spirulina platensis alleviates Cd-induced toxicity in mice by inhibiting liver inflammation mediated by gut microbiota
Researchers found that selenium-containing polysaccharide from Spirulina platensis alleviates cadmium-induced liver toxicity in mice by modulating gut microbiota composition and suppressing inflammatory pathways, suggesting a protective role against heavy metal exposure.
Bioavailability of Methionine-Coated Zinc Nanoparticles as a Dietary Supplement Leads to Improved Performance and Bone Strength in Broiler Chicken Production
Methionine-coated zinc nanoparticles used as a feed supplement in broiler chickens improved growth performance, zinc digestibility, and bone strength compared to conventional zinc sources. The results suggest amino acid-coated nano minerals could be a more bioavailable and effective form of mineral supplementation in poultry production.
Combined cerium and zinc oxide nanoparticles induced hepato-renal damage in rats through oxidative stress mediated inflammation
Researchers found that combined cerium and zinc oxide nanoparticles induced liver and kidney damage in rats through oxidative stress-mediated inflammation, demonstrating that co-exposure to multiple nanoparticles can produce synergistic toxic effects.
Manganese Benefits Heat-Stressed Corals at the Cellular Level
Researchers found that manganese at environmentally relevant concentrations benefited heat-stressed corals at the cellular level by supporting antioxidant defenses, suggesting that trace metal availability may modulate coral resilience to thermal bleaching.